Prostate Changes Related to Therapy: With Special Reference to Hormone Therapy

Mazzucchelli, Roberta; López-Beltrán, Antonio; Galosi, Andrea Benedetto; Zizzi, Antonio; Scarpelli, Marina; Bracarda, Sergio; Liu, Cheng; Montironi, Rodolfo

doi:10.2217/fon.14.37

Cited by 3 publications

(1 citation statement)

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“…Prostate biopsy in this setting aims to detect local recurrence/persistence of prostate cancer and evaluate the grade and extent of local extent [63]. However, because RT influences the prostate's histologic morphology and can kill tumor in a delayed fashion, this limits the ability to pathologically grade tumors with a significant radiation effect [64].…”

Section: Indication For Prostate Biopsy After Primary Radiation Therapymentioning

confidence: 99%

Evaluation of Recurrent Disease after Radiation Therapy for Patients Considering Local Salvage Therapy: Past vs. Contemporary Management

Adams,

Deivasigamani,

Mottaghi

et al. 2023

Cancers

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Recurrent prostate cancer after primary treatment with radiation therapy is a common problem. Patients with localized recurrence may benefit from salvage therapy, but careful patient selection is crucial because not all patients will benefit from local salvage therapy, and salvage therapy has increased morbidity compared to primary treatments for prostate cancer. This review aims to provide an overview of the evaluation of patients with recurrent disease after radiation therapy and how it is continuing to evolve with increasing data on outcomes, as well as improving technologies and techniques. Our enhanced understanding of treatment outcomes and risk stratification has influenced the identification of patients who may benefit from local salvage treatment. Advances in imaging and biopsy techniques have enhanced the accuracy of locating the recurrence, which affects treatment decisions. Additionally, the growing interest in image-targeted ablative therapies that have less morbidity and complications than whole-gland therapies for suitable patients influences the evaluation process for those considering focal salvage therapy. Although significant changes have been made in the diagnostic evaluation of patients with recurrent disease after radiation therapy, it remains unclear whether these changes will ultimately improve patient outcomes.

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Section: Indication For Prostate Biopsy After Primary Radiation Therapymentioning

confidence: 99%