Prostate cancer: Utility of fusion of T2‐weighted and high b‐value diffusion‐weighted images for peripheral zone tumor detection and localization

Rosenkrantz, Andrew B.; Mannelli, Lorenzo; Kong, Xiangbin; Niver, Ben E.; Berkman, Douglas S.; Babb, James S.; Melamed, Jonathan; Taneja, Samir S.

doi:10.1002/jmri.22598

Cited by 52 publications

(32 citation statements)

References 29 publications

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“…Woodfield et al [12] reported that tumours with a Gleason score of 6 were less likely to be visible on ADC maps. To our knowledge, only one study [19] has attempted to evaluate the incremental effect of adding DWI to T2-weighted imaging according to Gleason scores. For one of two readers in that study, the sensitivity of fused image sets of T2WI and high b-value (1,000 s/mm2) was significantly greater in the detection of tumours with a Gleason score greater than 6 than that of separate image sets.…”

Section: Discussionmentioning

confidence: 99%

Detectability of low and intermediate or high risk prostate cancer with combined T2-weighted and diffusion-weighted MRI

et al. 2012

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Section: Discussionmentioning

confidence: 99%

Detectability of low and intermediate or high risk prostate cancer with combined T2-weighted and diffusion-weighted MRI

et al. 2012

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“…There was greater sensitivity for tumours of higher grade or larger size [51]. Numerous studies have suggested strong correlation between Gleason score and tumour volume and between PSA level and tumour volume [52, 53].…”

Section: Discussionmentioning

confidence: 99%

The value of diffusion-weighted imaging in the detection of prostate cancer: a meta-analysis

2014

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ObjectivesTo evaluate the diagnostic performance of diffusion-weighted imaging (DWI) as a single non-invasive method in detecting prostate cancer (PCa) and to deduce its clinical utility.MethodsA systematic literature search was performed to identify relevant original studies. Quality of included studies was assessed by QUADAS-2 (Quality Assessment of Diagnostic Accuracy Studies). Data were extracted to calculate sensitivity and specificity as well as running the test of heterogeneity and threshold effect. The summary receiver operating characteristic (SROC) curve was drawn and area under SROC curve (AUC) served as a determination of the diagnostic performance of DWI for the detection of PCa.ResultsA total of 21 studies were included, with 27 subsets of data available for analysis. The pooled sensitivity and specificity with corresponding 95 % confidence interval (CI) were 0.62 (95 % CI 0.61–0.64) and 0.90 (95 % CI 0.89–0.90), respectively. Pooled positive likelihood ratio and negative likelihood ratio were 5.83 (95 % CI 4.61–7.37) and 0.30 (95 % CI 0.23–0.39), respectively. The AUC was 0.8991. Significant heterogeneity was observed. There was no notable publication bias.ConclusionsDWI is an informative MRI modality in detecting PCa and shows moderately high diagnostic accuracy. General clinical application was limited because of the absence of standardized DW-MRI techniques.Key points• DWI provides incremental information for the detection and evaluation of PCa• DWI has moderately high diagnostic accuracy in detecting PCa• Patient condition, imaging protocols and study design positively influence diagnostic performance• General clinical application requires optimization of image acquisition and interpretation

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“…High b values (often 1000 s/mm 2 ) are commonly preferred in prostate MRI studies (35). Diffusion tensor imaging (DTI) is a new emerging technique that is based on the calculation of anisotropic molecular diffusion of water molecules.…”

Section: Diffusion-weighted Mrimentioning

confidence: 99%

Local staging of prostate cancer with MRI

Soylu¹,

Eggener²,

Oto³

2011

Diagn Interv Radiol

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Prostate cancer: Utility of fusion of T2‐weighted and high b‐value diffusion‐weighted images for peripheral zone tumor detection and localization

Abstract: Fusion of T2WI and high b-value DWI resulted in significant improvements in sensitivity and accuracy for tumor detection on a sextant-basis, with similar specificity.

Cited by 52 publications

References 29 publications

Detectability of low and intermediate or high risk prostate cancer with combined T2-weighted and diffusion-weighted MRI

Detectability of low and intermediate or high risk prostate cancer with combined T2-weighted and diffusion-weighted MRI

The value of diffusion-weighted imaging in the detection of prostate cancer: a meta-analysis

Local staging of prostate cancer with MRI

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