Local staging of prostate cancer with MRI

Soylu, Fatma Nur; Eggener, Scott E.; Oto, Aytekin

doi:10.4261/1305-3825.dir.4970-11.2

Cited by 23 publications

(46 citation statements)

References 62 publications

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“…However, data in published series on MRI staging performance are conflicting, and influencing factors include variation in acquisition protocols, magnetic field strength (3.0/1.5 T), use of an endorectal coil and reader experience. 15,16 As MRI is increasingly being used in standard practice for local prostate cancer staging, the question rises whether a "limited" acquisition protocol would give acceptable results for appropriate patient care. In this study, prostate imaging was performed with a 1.5-T scanner without an endorectal coil and with only one functional MRI technique, i.e.…”

Section: Resultsmentioning

confidence: 99%

Staging of prostatic carcinoma at 1.5-T MRI: correlation of a simplified MRI exam with whole-mount radical prostatectomy specimens

Holsbeeck

Degroote²,

Wever

et al. 2016

BJR

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Objective: To retrospectively analyze the accuracy of simplified multiparametric MRI at 1.5 T for local staging by using whole-mount-section histopathological analysis as the standard of reference. Methods: 123 consecutive patients underwent T 2 weighted, T 1 weighted and diffusion-weighted MRI without endorectal coil prior to radical prostatectomy. The accuracy of predicting extracapsular extension (ECE) (T3a) was assessed using direct signs or the combination of direct and indirect signs of extraprostatic extension. The accuracy of predicting seminal vesicle invasion (T3b) was evaluated, taking into account different routes of seminal vesicle involvement. Finally, adjacent organ invasion (T4) was evaluated in this patient population. Results: Histopathology showed T3a, T3b and T4 in 61, 28 and 9 cases, respectively. The use of direct signs of extraprostatic extension showed a sensitivity of 57.4% and specificity of 91.9%. The combination of direct signs and indirect signs improved sensitivity (85.2%) at the expense of moderate loss of specificity (83.9%). MR sensitivity for the detection of seminal vesicle invasion was low (53.6%); however, it was dependent on the route of seminal vesicle tumour infiltration. MR sensitivity and specificity for adjacent organ invasion were 88.9% and 99.1%. Conclusion: Simplified MRI study at 1.5 T provides a relatively high sensitivity for detecting ECE (T3a) when using the combination of indirect and direct signs. However, this high sensitivity reading is at the cost of a moderate loss of specificity. Invasion of the seminal vesicles (T3b) occurs most often along the ejaculatory duct complex with low MR sensitivity. Advances in knowledge: Simplified MRI study at 1.5 T without endorectal coil could be used for the local T staging of prostate cancer.

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Section: Resultsmentioning

confidence: 99%

Staging of prostatic carcinoma at 1.5-T MRI: correlation of a simplified MRI exam with whole-mount radical prostatectomy specimens

Holsbeeck

Degroote²,

Wever

et al. 2016

BJR

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“…Furthermore, MRI allows more accurate differentiation and segmentation of the transition zone and peripheral zone (18)(19)(20)(21). Our group had validated total prostate volume derived from image segmentation of prostate images obtained on a 3.0 T MRI with the weights of human radical prostatectomy specimens (22).…”

Section: Role Of Prostatic Volume Determination In Bph Managementmentioning

confidence: 99%

Clinical value of prostate segmentation and volume determination on MRI in benign prostatic hyperplasia

Garvey¹,

Türkbey²,

Truong³

et al. 2014

Diagn Interv Radiol

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Benign prostatic hyperplasia (BPH) is a nonmalignant pathological enlargement of the prostate, which occurs primarily in the transitional zone. BPH is highly prevalent and is a major cause of lower urinary tract symptoms in aging males, although there is no direct relationship between prostate volume and symptom severity. The progression of BPH can be quantified by measuring the volumes of the whole prostate and its zones, based on image segmentation on magnetic resonance imaging. Prostate volume determination via segmentation is a useful measure for patients undergoing therapy for BPH. However, prostate segmentation is not widely used due to the excessive time required for even experts to manually map the margins of the prostate. Here, we review and compare new methods of prostate volume segmentation using both manual and automated methods, including the ellipsoid formula, manual planimetry, and semiautomated and fully automated segmentation approaches. We highlight the utility of prostate segmentation in the clinical context of assessing BPH. Benign prostatic hyperplasia (BPH) can result in lower urinary tract symptoms, and is one of the most common diseases affecting aging men. BPH can compromise quality of life and is a major healthcare cost. Despite the high prevalence of BPH, few methods of accurately assessing prostate volume are actually used in clinical practice. While patient assessment of urinary symptoms dictates the need for treatment, it is highly subjective, whereas prostate volume change is a more objective measure of treatment response. The most common clinical model for approximating the prostate gland size is the ellipsoid model from transrectal ultrasonography (TRUS) imaging, which has been shown to underestimate prostate volume for prostates larger than 50 mL and to overestimate prostate volume for glands smaller than 30 mL (1). Despite its limitations, the TRUS method of prostate volume assessment is preferred in current clinical practice due to its availability and cost and time efficiency (2). More accurate prostate volume measurement with magnetic resonance (MR) planimetry is time-intensive and, thus, rarely performed.Prostate segmentation is an accurate technique for prostate volume determination that can be used in coregistration with various imaging modalities, such as magnetic resonance imaging (MRI) with positron emission tomography and MRI with ultrasonography. Segmentation can be used for both diagnostic and interventional procedures, including guided biopsies and focal ablation. Newly developed methods of automated prostate segmentation allow for efficient prostate volume determination, thereby enhancing decision support systems and computer-aided diagnosis tools.This article reviews the major methods of prostate volume determination currently in use, including the ellipsoid formula, manual planimetry, and semiautomated and fully automated segmentation. A clinical overview of BPH is also provided to highlight the utility of prostate segmentation in the clinical management...

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“…With advances in technology, multichannel surface coil imaging of the prostate at 3T is now considered an acceptable alternative to endorectal coil imaging. No difference in local staging accuracy has been demonstrated with surface compared to endorectal coil imaging at 3T . More recently, studies have demonstrated similar accuracy for the detection of dominant tumor foci in the prostate gland using surface and endorectal coil imaging at 3T .…”

mentioning

confidence: 99%

Does a cleansing enema improve image quality of 3T surface coil multiparametric prostate MRI?

Lim

Quon

McInnes

et al. 2014

Magnetic Resonance Imaging

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Local staging of prostate cancer with MRI

Cited by 23 publications

References 62 publications

Staging of prostatic carcinoma at 1.5-T MRI: correlation of a simplified MRI exam with whole-mount radical prostatectomy specimens

Staging of prostatic carcinoma at 1.5-T MRI: correlation of a simplified MRI exam with whole-mount radical prostatectomy specimens

Clinical value of prostate segmentation and volume determination on MRI in benign prostatic hyperplasia

Does a cleansing enema improve image quality of 3T surface coil multiparametric prostate MRI?

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