Prostate cancer staging using imaging

Engelbrecht, Marc R.; Barentsz, Jelle O.; Jager, Gerrit J.; Heerschap, Arend; Sedelaar, J.P. Michiel; Aarnink, R.G.; Rosette, Jean J.M.C.H. de la

doi:10.1046/j.1464-410x.2000.00592.x

Cited by 54 publications

(32 citation statements)

References 71 publications

(96 reference statements)

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“…We agree with Engelbrecht and collaborators (19) on the importance of cost effectiveness in the future and its in uence on the use of accurate imaging. Preventing unnecessary radical treatment in the case of advanced disease and the use of appropriate palliation with correct diagnostic ndings of metastatic disease should be weighted against the cost of imaging.…”

Section: Discussionsupporting

confidence: 84%

Investigations with FDG-PET Scanning in Prostate Cancer Show Limited Value for Clinical Practice

et al. 2002

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Section: Discussionsupporting

confidence: 84%

Investigations with FDG-PET Scanning in Prostate Cancer Show Limited Value for Clinical Practice

et al. 2002

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“…However, the accuracy of TRUS in the detection and staging of tumors is more controversial. TRUS can detect hypoechoic lesions which have a high probability of being malignant, particularly in the peripheral zone of the prostate gland, but not all hypoechoic lesions are tumors and not all tumors are hypoechoic [9]. The American Cancer Society (ACS) recommends yearly DRE and PSA evaluations after the age of 50 [10].…”

Section: Introductionmentioning

confidence: 99%

Real-time elastography in the diagnosis of prostate tumor

Ferrari

Scorzelli

Megliola

et al. 2009

Journal of Ultrasound

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KEYWORDSProstate cancer; Ultrasonography; Real-time elastography.Abstract Aim: To assess the diagnostic gain of transrectal real-time elastography (RTE) compared to transrectal B-mode ultrasonography (US) in the detection of tumors in patients suspected of having prostate cancer. Materials and methods: Eighty-four patients suspected of having prostate cancer on the basis of clinical and biochemical evaluation underwent transrectal US, RTE and transperineal prostate biopsy. Results: Biopsy was considered the gold standard. Analysis related to the total number of patients showed a B-mode US sensitivity of 56%, specificity 80%, positive predictive value (PPV) 70% and negative predictive value (NPV) 67%. Analysis related to the total number of biopsy cores showed sensitivity 33%, specificity 92%, PPV 69% and NPV 73%. In the patientrelated analysis, RTE sensitivity was 51%, specificity 75%, PPV 64% and NPV 64%, while the core-related analysis showed sensitivity 36%, specificity 93%, PPV 72% and NPV 74%. Comparison of B-mode US and RTE diagnostic accuracy in the detection of tumors located in the peripheral zone of the prostate gland showed a significant difference. Analysis related to the total number of biopsy cores harvested in the peripheral zone of the prostate gland showed a B-mode US sensitivity of 48%, specificity 81%, PPV 75% and NPV 58%, whereas RTE achieved the following values: sensitivity 66%, specificity 78%, PPV 77%, and NPV 67%. Conclusions: RTE is a valid addition to B-mode US, and RTE reached a higher accuracy than Bmode US in the evaluation of the peripheral zone of the prostate gland and in the selection of appropriate biopsy sites.Sommario Scopo: Verificare il guadagno diagnostico dell'elastosonografia transrettale realtime (RTE) rispetto alla ecografia transrettale B-mode nel rilievo del tumore prostatico in una popolazione di pazienti con sospetto di neoplasia. Materiali e metodi: Ottantaquattro pazienti con sospetto clinico-laboratoristico di tumore prostatico sono stati valutati mediante ecografia transrettale, elastosonografia e biopsia transperineale. Risultati: L'esame bioptico è stato considerato lo standard di riferimento. Nella valutazione per paziente, la sensibilità dell'ecografia B-mode è stata del 56%; la specificità dell'80%; il valore predittivo positivo (VPP) del 70%, il valore predittivo negativo (VPN) del 67%. Nella valutazione sul totale dei prelievi bioptici la sensibilità è stata del 33%, la specificità del 92%, il VPP del 69%, il VPN del 73%. La RTE ha ottenuto i seguenti risultati nella valutazione per paziente: sensibilità 51%, specificità 75%, VPP 64% e VPN 64%. Nella valutazione sul totale dei prelievi bioptici: sensibilità 36%, specificità 93%, VPP 72%, VPN 74%. Confrontando i valori di accuratezza dell'ecografia B-mode e della RTE per i tumori della zona periferica, è stata trovata una differenza significativa. Nella valutazione sul totale dei prelievi bioptici della zona periferica la sensibilità dell'ecografia B-mode è stata del 48%, la specificità dell'81%, il VPP d...

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“…The sensitivity and specificity of TRUS are limited, ranging between 40% and 50% for detecting prostate cancer. Lesions on TRUS are better visualized in the peripheral zone than in the transitional zone because of the heterogeneous pattern of the latter (9). Additional findings on TRUS that may suggest, but are not specific for, underlying malignancy include bulging or irregularity of the prostatic capsule and asymmetry of the prostate gland in terms of morphology and echogenicity (10).…”

Section: Gray-scale Ultrasoundmentioning

confidence: 99%

Utility of Ultrasound in the Diagnosis, Treatment, and Follow-up of Prostate Cancer: State of the Art

2016

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Prostate cancer screening currently consists of serum prostatespecific antigen and digital rectal examination, followed by transrectal ultrasound-guided biopsy for diagnostic confirmation. Although the current paradigm of prostate cancer screening has led to a decrease in advanced disease and cancer-related mortality, these techniques have limitations in terms of sensitivity and specificity, resulting in missed cancers that are clinically significant and the overdetection of clinically insignificant cancers. New imaging techniques and technologies are required to improve the detection of prostate cancer. This article summarizes the use of novel ultrasound techniques and technologies in the detection, biopsy, and treatment of prostate cancer.

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Prostate cancer staging using imaging

Cited by 54 publications

References 71 publications

Investigations with FDG-PET Scanning in Prostate Cancer Show Limited Value for Clinical Practice

Investigations with FDG-PET Scanning in Prostate Cancer Show Limited Value for Clinical Practice

Real-time elastography in the diagnosis of prostate tumor

Utility of Ultrasound in the Diagnosis, Treatment, and Follow-up of Prostate Cancer: State of the Art

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