Prostate Cancer Overview

Dunn, Mary; Kazer, Meredith Wallace

doi:10.1016/j.soncn.2011.07.002

Cited by 95 publications

(64 citation statements)

References 26 publications

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“…However, studies such as those by Drobnjak et al (6), Kallakury et al (15), Comstock et al (16), and Ilia Anis et al (17) have found statistically significant positive and negative correlations of cyclin D1 expression and PSA levels. Nakamura et al (10) reported that cyclin D1 expression might be regulated by sex hormones, indicating a possible relationship between PSA levels and cyclin D1, since PSA production is dependent on hormonal stimulation (1). Nonetheless, further studies are needed to determine the true relationship between PSA levels and cyclin D1 expression in order to confirm these hypotheses.…”

Section: Discussionmentioning

confidence: 99%

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Cyclin D1 expression in prostate carcinoma

Pereira

Ravinal

Costa

et al. 2014

Braz J Med Biol Res

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The purpose of this study was to investigate the relationship between cyclin D1 expression and clinicopathological parameters in patients with prostate carcinoma. We assessed cyclin D1 expression by conventional immunohistochemistry in 85 patients who underwent radical prostatectomy for prostate carcinoma and 10 normal prostate tissue samples retrieved from autopsies. We measured nuclear immunostaining in the entire tumor area and based the results on the percentage of positive tumor cells. The preoperative prostate-specific antigen (PSA) level was 8.68±5.16 ng/mL (mean±SD). Cyclin D1 staining was positive (cyclin D1 expression in >5% of tumor cells) in 64 cases (75.4%) and negative (cyclin D1 expression in ≤5% of tumor cells) in 21 cases (including 15 cases with no immunostaining). Normal prostate tissues were negative for cyclin D1. Among patients with a high-grade Gleason score (≥7), 86% of patients demonstrated cyclin D1 immunostaining of >5% (P<0.05). In the crude analysis of cyclin D1 expression, the high-grade Gleason score group showed a mean expression of 39.6%, compared to 26.9% in the low-grade Gleason score group (P<0.05). Perineural invasion tended to be associated with cyclin D1 expression (P=0.07), whereas cyclin D1 expression was not associated with PSA levels or other parameters. Our results suggest that high cyclin D1 expression could be a potential marker for tumor aggressiveness.

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Section: Discussionmentioning

confidence: 99%

“…Prostate carcinoma is the most common malignant tumor in men older than 50 years of age and is characterized by a highly variable clinical course (1,2). Accordingly, many potential prognostic markers have been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

Cyclin D1 expression in prostate carcinoma

Pereira

Ravinal

Costa

et al. 2014

Braz J Med Biol Res

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“…Prostate cancer (PCa) is the second leading cause of male malignancy death throughout the world (Dunn and Kazer 2011). In Chile, this disease reached that level very rapidly and currently over 1,700 patients die annually due to this cancer, representing an observed rate exceeding 20 per 100,000 men (Minsal 2011).…”

Section: Introductionmentioning

confidence: 99%

Molecular signature of cancer stem cells isolated from prostate carcinoma and expression of stem markers in different Gleason grades and metastasis

et al. 2012

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Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Chemotherapy response is very poor and resistance to hormone-based treatments is frequent in advances stages. Recently, tumor-initiating cells or cancer stem cells (CSCs) have been identifi ed in several cancers, including PCa. These cells are thought to be responsible for therapy resistance, relapse and metastasis. In the present work, enriched populations of CSCs were obtained using a mixed procedure that included diff erential clone-forming ability, sphere growing induction (prostatospheres) and magnetic-associated cell sorting (MACS). Also, stem marker expression was determined in PCa biopsies of diff erent histological grades and metastasis samples. The signature for stem markers of the isolated CSCs was CD133+/CD44+/ABCG2+/ CD24-. Expression of stem markers (CD133, CD44, and ABCG2) was higher in medium Gleason biopsies than in lower and higher grades, and lymph-node and bone metastasis samples. These results suggest that the CSCs in PCa reach an important number in medium Gleason grades, when the tumor is still confi ned into the gland. At this stage, the surgical treatment is usually with curative intention. However, an important percentage of patients relapse after treatment. Number and signature of CSCs may be a prognosis factor for PCa recurrence.

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“…Number of individuals with the diagnosis of prostate cancer will increase in the elderly population. [3] Prostate cancer is a rare cause of death before the age of 50, and mortality rates peak after age of 75. [4] Therefore, countries with a high proportion of aging population should prioritize preventive measures against the deleterious effects of prostate cancer on health.…”

Section: Introductionmentioning

confidence: 99%

“…Risks, benefits, and alternatives should be offered to them. [3] In this study, we have aimed to inform male participants aged 50 years or over without any established diagnosis of prostate cancer about prostate cancer, and screening tests, and analyze their attitudes towards participation in screening test methods. In accordance with this aim, the hypotheses of this study encompass the following statements: (1) "offered educational courses increase level of knowledge" (2) "educational courses increase frequency of participation in screening tests".…”

Section: Introductionmentioning

confidence: 99%

The impact of educational sessions provided on prostate cancer, and its screening tests on the knowledge level, and participation behavior of the individuals in questionnaire surveys

Çapık

2014

Turkish Journal of Urology

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Objective: The purpose of this study is to inform male participants aged fifty and older who have not been diagnosed with prostate cancer about prostate cancer screenings and to examine their participation behavior in these screenings. Material and methods:In this study, in which an experimental design with a pretest-posttest control group was used, data were collected from 3 family health centers in the city center of Kars between April and July 2013. The sample group consisted of 113 male participants aged fifty years or over. A personal information and a knowledge test forms about prostate cancer screening were used to collect the data. The statistical power of the study was determined to be 0.99. Results:The mean pretest knowledge scores of the participants were determined be similar. In the posttest, the mean knowledge score of the experimental group was significantly increased compared to that of the control group. In terms of screening participation frequency, there was no statistically significant difference between the two groups during the period after the training. The knowledge level was higher in patients who had previously undergone a prostate examination and/or their prostate specific antigen (PSA) level measured or those with a family history of prostate cancer or in cases with a history of a benign prostatic disease. Conclusion:This study revealed that the knowledge level of the risk group can be increased by training. The study also found that the increase in the knowledge level did not affect the participation behavior of the individuals in the screening tests.

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Prostate Cancer Overview

Cited by 95 publications

References 26 publications

Cyclin D1 expression in prostate carcinoma

Cyclin D1 expression in prostate carcinoma

Molecular signature of cancer stem cells isolated from prostate carcinoma and expression of stem markers in different Gleason grades and metastasis

The impact of educational sessions provided on prostate cancer, and its screening tests on the knowledge level, and participation behavior of the individuals in questionnaire surveys

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