Prostate cancer: morbidity and mortality trends in Kemerovo Region

Abstract

Aim. To study current trends in the incidence and mortality of prostate cancer in Kemerovo Region.Materials and Methods. We conducted a descriptive retrospective study by investigating cancer registry of Regional Clinical Oncology Dispensary collected in 2010-2018.Results. During the study period, 4965 cases of prostate cancer have been documented. The average standardised incidence rate was 50,080/0000 (95% CI = 46.01; 54.43). We detected a trend towards an increase in standardized incidence from 32.410/0000 in 2010 (95% CI = 28.76; 36.05) to 73.000/0000 in 2018 (95% CI = 67.86 – 78.15) with the average annual increment of 10.22% (р < 0.0001). A significant proportion of cases (48.17% in 2018) occurred in elderly (≥ 70 years). Standardized mortality rates increased from 9.240/0000 in 2010 (95% CI = 7.29; 11.19) to 28,830/0000 in 2018 (95% CI = 25.51; 32.15), average annual increment 13.99% (р = 0.002). Component analysis showed that an incidence increase by 155.81% is primarily associated with existing risk factors (128.19%) rather than with population aging (16.71%) or their combined effect (10.91%).Conclusion. Currently, there is a clear trend to increasing incidence and mortality from prostate cancer in Kemerovo Region, mainly due to existing risk factors.