Prostate—An Extrapituitary Source of Follicle Stimulating Hormone

Garde, Seema V.; Sheth, A. R.

doi:10.1007/978-1-4684-7103-8_29

Cited by 1 publication

(2 citation statements)

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“…These studies are suggestive that reduction of FSH levels might prove beneficial in the treatment of prostate cancer. Earlier studies have surprisingly shown immunocytochemical localization of FSH in the prostate epithelial cells of various species, including man [6,8,24]. Furthermore, it has been demonstrated that de novo biosynthesis of FSH in prostate specimens can occur in vitro [7].…”

Section: Discussionmentioning

confidence: 99%

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Effect of prostatic inhibin peptide (PIP) on prostate cancer cell growth in vitro and in vivo

et al. 1993

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Prostatic inhibin peptide (PIP), is a 94 amino acid protein which is secreted by the prostate gland in an androgen-independent manner. Previously, it has been demonstrated that PIP appears to inhibit follicle-stimulating-hormone (FSH) secretion by the pituitary and prostate glands. In vitro, the Dunning R3327 rat prostate cancer cell line MAT-LyLu (MLL) cells and the human prostate cancer cell line PC-3, are stimulated to grow in response to exogenous FSH and these effects are blocked by PIP. In vivo, PIP inhibits the growth of the highly metastatic MLL prostate cancer cell line. A comparison of hormone levels in control and PIP-treated rats demonstrates a significant inhibition of FSH in treated animals. It appears that, in vivo, PIP may inhibit prostate cancer growth by inhibiting FSH. PIP may represent a novel hormonal treatment for prostate cancer.

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Section: Discussionmentioning

confidence: 99%

“…On day 14, animals were euthanized with methoxyflurane and cardiac puncture was performed to obtain a blood sample. Serum concentrations of each hormone were done by RIA assay [8,15]. Tumors were excised and weighed.…”

Section: Experimental Treatmentmentioning

confidence: 99%