Prostanoids as pharmacological targets in COPD and asthma

Rolin, Stéphanie; Masereel, Bernard; Dogné, Jean-Michel

doi:10.1016/j.ejphar.2005.12.058

Cited by 84 publications

(64 citation statements)

References 136 publications

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“…It is well accepted that arachidonic acid metabolites (prostanoids and isoprostanes) play a key role in the pathophysiology of diseases associated with infl ammation, platelet aggregation and vasoconstriction/relaxation. Consequently, the inhibition of their production and/or the blockade of their respective receptors have greatly contributed to the understanding of their mode of action and their involvement in the pathology, and have also demonstrated clinical effectiveness in bronchial asthmas (Rolin et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Isolation of syringaldehyde from Mikania laevigata medicinal extract and its influence on the fatty acid profile of mice

Pedroso¹,

Santos²,

Steil³

et al. 2008

Rev. bras. farmacogn.

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RESUMO: "Extrato medicinal de Mikania laevigata: infl uência no perfi l de ácidos graxos em camundongos e isolamento de siringaldeído por CLAE semipreparativa". O gênero Mikania é popularmente conhecido como "guaco" e é utilizado para tratar febre, reumatismo, resfriados e afecções respiratórias. Em trabalho prévio demonstramos sinergismo entre os componentes do extrato de M. laevigata para produzir os efeitos farmacológicos esperados, incluindo a cumarina e seu precursor ácido o-cumárico como marcadores. Muitas espécies de Mikania são produtoras de diterpenos ent-caurenos que apresentam atividade antispasmódica e relaxante da musculatura lisa. Buscando a padronização do extrato medicinal de guaco (preparado segundo a farmacopéia brasileira 1ª edição), este trabalho visou determinar a presença de ácido caurenóico através de CLAE-DAD e isolou siringaldeído através de CLAE semipreparativa, sendo que o primeiro não foi encontrado no extrato e o siringaldeído é um dos seus componentes majoritários. Camundongos isogênicos Balb-C portadores de pneumonite alérgica foram tratados com este extrato, e amostras de pulmão e fígado foram analisadas por CG-DIC quanto ao seu conteúdo de ácidos graxos. A quantidade de ácido araquidônico (ARA) e de ácido docosahexaenóico (DHA) encontrada demonstrou que a composição é distinta em ambos tecidos, e apenas a concentração de DHA hepático foi alterado em função do tratamento, o qual não foi encontrado no pulmão. Não foi detectada diferença signifi cativa na produção de ARA. Tanto o extrato aquoso, quanto a cumarina e o ácido o-cumárico, estimularam a síntese de DHA no fígado (p < 0.05). Unitermos:Mikania laevigata, Asteraceae, ácido caurenóico, siringaldeído, ácido araquidônico, ácido docosahexaenóico. ABSTRACT:The Mikania genus is widely known as "guaco" and is used to treat fever, rheumatism, fl u and respiratory diseases. Our previous work evidenced the synergism among M. laevigata extract components to produce desirable effects, and included the coumarin precursor, o-coumaric acid as marker. Many Mikania species are producers of ent-kaurene diterpenes which presented antiespasmodic and relaxant activities on smooth muscle. Seeking to standardize the guaco extract, which is registered in the Brazilian Pharmacopoea, this paper deals with the determination of kaurenoic acid through LC-PDA and the isolation through LC of syringaldehyde. Kaurenoic acid was not found in the extract, and syringaldehyde is one of the major compounds of pharmacopoeal extract, together with coumarin and o-coumaric acid. Samples from the lung and liver of Balb-C isogenic allergic pneumonitis bearing mice, treated with the same extract, were analyzed through GC-FID, and the fatty acid content was determined and analyzed. The results obtained by measuring the arachidonic acid (ARA) and docosahexaenoic acid (DHA) in the liver and lung of treated animals demonstrated that the fatty acid composition is distinct in both tissues, and that in the liver, only the DHA was altered as a result of the treatments. DHA is ...

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Section: Introductionmentioning

confidence: 99%

Isolation of syringaldehyde from Mikania laevigata medicinal extract and its influence on the fatty acid profile of mice

Pedroso¹,

Santos²,

Steil³

et al. 2008

Rev. bras. farmacogn.

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“…Nevertheless, even recently the TP antagonist terutroban was shown to exhibit superior antithrombotic activity compared with as- PROSTAGLANDIN RECEPTORS pirin in humans (Bal Dit Sollier et al, 2009). Another early indication for TP antagonists was asthma, which met with some clinical success, albeit limited (Rolin et al, 2006;Jones et al, 2009). Other early indications do not seem to have met with any clinical success.…”

mentioning

confidence: 99%

International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

Woodward

Jones

Narumiya³

2011

Pharmacol Rev

391

414

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“…• Après une stimulation allergique, la production d'IgE active les mastocytes qui sécrétent environ 50 média-teurs chimiques différents dont la PGD2, qui vont tous contribuer à la réponse allergique [20]. La PGD2 induit la production d'histamine puis une vasodilatation dans la muqueuse nasale, une bronchoconstriction et le recrutement et l'activation des lymphocytes Th2 et des éosinophiles via les récepteurs DP1, TP et CRTH2 respectivement [21,22].…”

Section: Les Rôles De La Prostaglandine D2unclassified