Prostaglandins in carcinomas of the head and neck

Karmali, Rashida A.; Wustrow, T. P. U.; Thaler, H. T.; Strong, E.W.

doi:10.1016/0304-3835(84)90171-x

Cited by 32 publications

(13 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In several studies analyzing HNSCC, increased levels of PGE 2 or of the inducible isoform of the rate-limiting enzyme of PGE 2 synthesis, COX-2, have been reported in the tumor cells [5,[19][20][21] . Increased levels of PGE 2 are likely to favor HNSCC growth and progression as they might promote proliferation and angiogenesis or inhibit immune surveillance [22][23][24] .…”

Section: Discussionmentioning

confidence: 99%

Increased PGE<sub>2</sub> Levels in Nonmalignant Mucosa Adjacent to Squamous Cell Carcinoma of the Head and Neck

Schuon¹,

Brieger²,

Franke³

et al. 2005

ORL

View full text Add to dashboard Cite

Objective: The cyclooxygenases (COX) 1 and 2 are the rate-limiting enzymes of prostaglandin E₂ (PGE₂) synthesis, and the upregulation of COX-2 has been reported in tumors of different origins. The aim of our study was to quantify the PGE₂ expression in squamous cell carcinoma and surrounding mucosa, to analyze the potential of acetylsalicylic acid (ASA) for reducing PGE₂ levels in these tissues, and to improve our understanding of potential tumor-derived stimulation of surrounding mucosa by PGE₂. Study Design and Setting: Intracellular PGE₂ levels in primary head and neck squamous cell carcinoma (HNSCC) and the surrounding mucosa at 1 and 2 cm distance were analyzed ex vivo by ELISA. Subsequently, we treated in vitro tumor and normal mucosal cells from turbinates with recombinant PGE₂ and ASA, and quantified intracellular PGE₂ levels. Results: We observed high PGE₂ levels in the tumor samples and in tumor-surrounding mucosa. The addition of PGE₂ and arachidonic acid to tumor cell cultures resulted in no further increase in intracellular PGE₂ levels, while ASA reduced PGE₂ levels by up to 40%. In normal epithelial cell cultures, less PGE₂ (6% of that found in the tumor cells) was expressed, but stimulation with PGE₂ resulted in levels comparable to those of the tumor samples. Conclusion and Significance: We conclude that HNSCC and the surrounding mucosa express high levels of PGE₂. This expression is reduced efficiently by ASA. We propose a stimulation of PGE₂ expression in the epithelium surrounding HNSCC by tumor-derived PGE₂ with a potential impact on tumor growth.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased PGE<sub>2</sub> Levels in Nonmalignant Mucosa Adjacent to Squamous Cell Carcinoma of the Head and Neck

Schuon¹,

Brieger²,

Franke³

et al. 2005

ORL

View full text Add to dashboard Cite

show abstract

“…Therefore, COX-2 inhibitor drugs can be used in irradiated cancer patients to find out their impact on postradiation tumour recurrence. COX-2 is markedly up-regulated in head and neck SCC [5,16,17]. It was shown that there is nearly a 150-fold increase in amounts of COX-2 mRNA in head and neck SSC versus normal oral mucosa, and the level of COX-2 mRNA is also increased 50-fold in normalappearing epithelium adjacent to tumour tissue compared with normal mucosa [5].…”

Section: Discussionmentioning

confidence: 99%

Cyclo-Oxygenase 2 Expression in Laryngeal Squamous Cell Carcinoma and Its Clinical Correlates

Bayazıt

Büyükberber²,

Sarı³

et al. 2004

ORL

View full text Add to dashboard Cite

Objective: To assess the significance of cyclo-oxygenase 2 (COX-2) in laryngeal squamous cell carcinoma (LSCC). Study Design: An immunohistochemical study in which 39 patients with LSCC were included. Methods: Immunohistochemical staining of the paraffin-embedded tumour tissues was performed using isoform-specific COX-2 polyclonal antisera (Santa Cruz, Calif., USA). COX-2 results were compared with the clinical parameters of the patients. Results: COX-2 was detected in all tumour tissues. In the normal laryngeal tissue around the tumour area, which served as control, there was no COX-2 staining. There was no relationship between the COX-2 results and the location of the primary tumour, T stage and N stage, survival, recurrence or pulmonary metastases. Conclusion: The absence of a relation between COX-2 positivity and clinical parameters may suggest an involvement of COX-2 in laryngeal carcinogenesis. Since COX-2 positivity could be detected in all LSCC specimens studied, COX-2 could serve as a therapeutic target in LSCC.

show abstract

“…21 Moreover, it is well known that patients with advanced stage squamous cell carcinoma demonstrate clinical signs of immunosuppression. These immunosuppressive characteristics appear to be a result of tumor adherent macrophage's effects on tumor infiltrating lymphocytes, 22,23 and may involve prostaglandins [24][25][26] or apoptosis. 27 The largest cellular producer of NOи is the macrophage, but all cells in the body possess the potential to upregulate the inducible isoform of nitric oxide synthase (iNOS or NOS-2).…”

Section: Discussionmentioning

confidence: 99%

Increased protein nitrosylation in head and neck squamous cell carcinogenesis

2000

View full text Add to dashboard Cite

Background Nitric oxide (NO·) and its metabolic byproducts are implicated in carcinogenesis. We examined a marker of NO·‐species' pathologic protein nitrosylation, nitrotyrosine, during head and neck squamous cell carcinoma (HNSCCa) development. Materials and Methods Paraffin‐embedded tissue samples of normal oral mucosa, squamous hyperplasia/dysplasia, and HNSCCa were immunohistochemically analyzed for staining intensity using an antinitrotyrosine monoclonal antibody, and correlated with retrospective clinical data. Results Significantly higher staining was noted in reactive, dysplastic and HNSCCa samples compared with samples of normal mucosa. Additionally, significant differences in staining were found between various primary sites of the upper aerodigestive tract. Lastly, individual inflammatory cells also stained intensely. Conclusions Increasing amounts of nitrotyrosine staining were found in reactive/dysplastic and HNSCCa lesions compared to normal squamous mucosa. Inflammatory cell staining implicates NO· as a possible mediator of immunosuppression. Given these findings, the role of NO· in mutations leading to and the immunosuppression found in HNSCCa warrants further investigation. © 2000 John Wiley & Sons, Inc. Head Neck 22: 64–70, 2000.

show abstract

Prostaglandins in carcinomas of the head and neck

Cited by 32 publications

References 5 publications

Increased PGE<sub>2</sub> Levels in Nonmalignant Mucosa Adjacent to Squamous Cell Carcinoma of the Head and Neck

Increased PGE<sub>2</sub> Levels in Nonmalignant Mucosa Adjacent to Squamous Cell Carcinoma of the Head and Neck

Cyclo-Oxygenase 2 Expression in Laryngeal Squamous Cell Carcinoma and Its Clinical Correlates

Increased protein nitrosylation in head and neck squamous cell carcinogenesis

Contact Info

Product

Resources

About