Prostaglandin synthetase inhibitors and leucocytic emigration

Blackham, A.; Owen, R T

doi:10.1111/j.2042-7158.1975.tb09439.x

Cited by 54 publications

(15 citation statements)

References 10 publications

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“…Although indomethacin and other NSAIDs have been shown to decrease plasma PGE 2 concentration 7 , no such finding has been reported for the extract.…”

Section: Discussionmentioning

confidence: 64%

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In vivo inhibition of prostaglandin e2 production by crude aqueous extract of the root bark of zanthoxylumxanthoxyloides

Prempeh

Mensah-Attipoe²

2009

Ghana Medical Journal

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SUMMARYBackground: Crude aqueous extract of the root bark of Zanthoxylum xanthoxyloides is used in folklore medicine for its anti-inflammatory activity. Although it shares the analgesic and anti-inflammatory property of non-steroidal anti-inflammatory drugs (NSAIDs), its mechanism of action has not been well elucidated. Objective: To ascertain whether the extract decreases carrageenin-induced increase in plasma prostaglandin E 2 (PGE 2 ) concentration with the view to shed light on the mechanism of action. Methods: The extract was obtained by Soxhlet extraction and rotatory evaporation, followed by freezedrying. Forty Wistar rats (150g -200g) were assigned to 8 groups of 5 rats each. The rats were given four different treatments orally: 0.9% saline (two groups of control); two groups received indomethacin, 20mg/kg and 40mg/kg respectively; another two groups received the extract, 2000mg/kg and 4000mg/kg respectively; and the remaining two groups, 50mg/kg and 100mg/kg nimesulide respectively. Inflammation was induced with carrageenin in one of the two groups of control. Enzyme-linked immunospecific assay was used to measure plasma PGE 2 concentration in the control and treated groups of rats. Analysis of variance was used as the statistical test. Differences in means at p<0.05 were considered significant. Results: Carrageenin increased plasma PGE 2 concentration which was reduced by the extract, indomethacin and nimesulide. High dose extract and indomethacin reduced plasma PGE 2 concentration to a comparable extent which was much greater than that of the reduction caused by nimesulide. Conclusion: It was concluded that the extract might act by non-selective inhibition of cyclooxygenase 1 and 2 to decrease plasma PGE 2 concentration.

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“…Although indomethacin and other NSAIDs have been shown to decrease plasma PGE 2 concentration 7 , no such finding has been reported for the extract.…”

Section: Discussionmentioning

confidence: 64%

“…NSAIDs produce their anti-inflammatory activity by: 1) inhibiting the release or biosynthesis of chemical mediators 5,6 ; 2) inhibiting migration of inflammatory cells 7,8 ; and 3) inhibiting expression of cell adhesion molecules. 9,10 All NSAIDs share the first mechanism.…”

Section: Introductionmentioning

confidence: 99%

In vivo inhibition of prostaglandin e2 production by crude aqueous extract of the root bark of zanthoxylumxanthoxyloides

Prempeh

Mensah-Attipoe²

2009

Ghana Medical Journal

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“…Cell membrane phospholipase is activated with arachidonic acid and subsequent PG and leukotriene production [22]. PG [23], and to a greater extent leukotrienes [24], exert leukocyte chemotoxic properties. Polymorphonuclear and mononuclear cells migrate to the wound and stimulate fibroblast activity with resultant collagen deposition [25].…”

Section: Discussionmentioning

confidence: 99%

The effect of indomethacin on acute radiation induced gastrointestinal injury: A morphologic study

Rose

Halter

1992

Journal of Surgical Oncology

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Radiation-induced intestinal injury is a dose limiting factor in the treatment of pelvic, abdominal, and retroperitoneal malignancies with radiation therapy. In experimental models, radiation has been associated with increased intestinal prostaglandin activity and in clinical trials prostaglandin inhibitors have been demonstrated to improve the symptoms of acute radiation enteritis. This study was conducted to determine if the prostaglandin inhibitor indomethacin could prevent the morphologic changes of acute radiation induced intestinal injury. Twenty-four male rats received either parenteral indomethacin at doses of 0.5, 1.0, and 3.0 mg/kg per dose every 12 hours or saline from 24 hours pre-radiation exposure until sacrifice 48 hours later. Twenty-four control animals received identical drug dosages and anesthesia but no radiation. Radiation produced a decreased villus/crypt ratio and increased acute inflammation and degeneration. Indomethacin treated animals demonstrated significantly less polymorphonuclear leukocyte infiltration and decreased degeneration. Villus/crypt ratio was not affected by indomethacin.

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“…Nonsteroid anti-inflammatory drugs in doses which block increased permeability, seem: (a) to interfere with migration of cells in some models, such as pleurisy induced by carrageenin (BLACKHAM and OWEN, 1975), (b) not to interfere in others ( VAN AR-MAN and CARLSON, 1974), and (c) to have different effects depending on the type and intensity of the stimulus, such as in the migration of leucocytes into subcutaneous implanted sponges (SMITH et ai., 1975;HIGGS et ai., 1976).…”

Section: Action On Step 6: Inhibition Of Cell Migrationmentioning

confidence: 97%

Mode of Action of Anti-Inflammatory Agents Which are Prostaglandin Synthetase Inhibitors

Ferreira¹,

Vane²

1979

Handbook of Experimental Pharmacology

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This review is mainly concerned with the mechanism of action of those non-steroid anti-inflammatory drugs used to ameliorate the signs and symptoms of human acute and chronic inflammation which have the common property of inhibiting fatty acid oxidative cyclization, in particular the formation of prostaglandins (PGs) and thromboxanes. We have retained for this group of substances the term PG synthetase inhibitors because thromboxane synthetase can be selectively inhibited by substances which do not affect PG synthesis and do not show anti-inflammatory activity . Other types of non-steroid anti-inflammatory agents are reviewed in subsequent chapters.

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Prostaglandin synthetase inhibitors and leucocytic emigration

Cited by 54 publications

References 10 publications

In vivo inhibition of prostaglandin e2 production by crude aqueous extract of the root bark of zanthoxylumxanthoxyloides

In vivo inhibition of prostaglandin e2 production by crude aqueous extract of the root bark of zanthoxylumxanthoxyloides

The effect of indomethacin on acute radiation induced gastrointestinal injury: A morphologic study

Mode of Action of Anti-Inflammatory Agents Which are Prostaglandin Synthetase Inhibitors

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