Prostaglandin synthesis by murine mammary gland is modified by the state of the estrus cycle

Knazek, Richard A.; Watson, Kathryn; Lim, Meng F.; Cannizzaro, Anna M.; Christy, Robert J.; Liu, Sue C.

doi:10.1016/0090-6980(80)90123-9

Cited by 5 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our search for this factor or factors, we observed that type E prostaglandins (PGE) were 2-3-fold more abundant in TIF than in the subcutaneous fluid sampled by a millipore chamber located in the same rat (1043 versus 405 pg/ml on average) [17].…”

Section: Prostaglandin E1mentioning

confidence: 99%

Gangliosides, copper ions and angiogenic capacity of adult tissues

1990

View full text Add to dashboard Cite

The report summarizes the work of our laboratory aimed at improving the understanding of the angiogenic response of adult tissues, an event that transforms a micro-embolus of neoplastic cells into a growing metastasis. Attention has been focused on tumor-induced angiogenesis. The following aspects of the subject are discussed: (a) relationship between size of vascular network and tumor growth rate or tumor cell population; (b) angiogenic capacity of tumors and role that prostaglandin E1 may have as an angiogenesis factor; (c) relationship between acquisition of angiogenic capacity and neoplastic transformation of a cell population; (d) modification of tissue composition at the onset of angiogenesis; (e) behaviour of copper ions and copper carriers in the course of the angiogenic response; (f) the influence of gangliosides on endothelial cell motility, survival and growth in vitro; (g) modulation of the angiogenic response by gangliosides (GM1, GT1b) in vivo.

show abstract

Section: Prostaglandin E1mentioning

confidence: 99%

Gangliosides, copper ions and angiogenic capacity of adult tissues

1990

View full text Add to dashboard Cite

show abstract

“…Rolland and Martin (20) showed that exogenously added estrogen stimulated prostaglandin synthetase activity in microsomal preparations from human breast tumors. It may be significant, in regard to this study, that both prostaglandin E2 and F2~ synthesis in the mouse mammary gland have been shown to vary with stage of estrus, with highest levels at early diestrus (21). There is now growing evidence that other hormones may exert their effects via prostaglandins (22).…”

mentioning

confidence: 94%

Tumor-associated prostaglandins in patients with primary breast cancer: Relationship to clinical parameters

Fulton

Roi

Howard

et al. 1982

Breast Cancer Res Tr

View full text Add to dashboard Cite

SummaryDetermination of the levels of prostaglandin E2 (PGE2) and PGF2~ were carried out using homogenized primary human breast tumors. Measurable levels of both prostaglandins were found in all but one tumor examined. In most samples, the absolute PGF2~ level was higher than that of PGE2. Higher PGE2 levels are more often seen in postmenopausal women than in pre-or perimenopausal patients, though among postmenopausal women, PGE2 levels do not correlate with age. Thus, the ratio of P G F : P G E is higher in pre/perimenopausal women than in postmenopausal women. Differences in PGF2~ do not appear to be associated with age or menopausal status.Tumors that are estrogen receptor positive (ER +) tend to have higher PGE2 levels than ER negative tumors. PGF2~ is not associated with the presence of ER and neither prostaglandin is associated with the presence of progesterone receptor. Higher levels of both PGE2 and PGF2~ are associated with less differentiated tumors, while tumor maximum diameter is negatively associated with PGE2 levels.

show abstract

“…in the absence of infusions of arachidonate, level of 6-oxo-PGF1,, and TxB2 in effluent from lungs during pro-oestrus. Variations in prostaglandin synthesis under the influence of the oestrous cycle have already been reported for guinea-pig uterus (Blatchley Donovan, Horton & Poyser, 1972;Poyser, 1972) and mouse mammary glands (Knazek, Watson, Lim, Cannizzaro, Christy & Liu, 1980). Fig.…”

Section: Discussionmentioning

confidence: 63%

Effects of the oestrous cycle on the metabolism of arachidonic acid in rat isolated lung.

Bakhle¹,

Zakrzewski²

1982

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The metabolism of exogenous arachidonic acid perfused through the pulmonary circulation was investigated in lungs taken from rats at different stages ofthe oestrous cycle.2. Following perfusion with [14C]arachidonic acid there was more radioactivity associated with cyclo-oxygenase products in general at pro-oestrus than at any other stage of the cycle.3. Production of6-oxo-prostaglandin Fa, and hence ofprostacyclin (PGI2) was also highest at pro-oestrus.4. Production of thromboxane B2 was highest at pro-oestrus although it was never greater than PGI2 production at any stage.5. Radioactivity retained in lung tissue was mostly present in phospholipid and free fatty acid fractions with the distribution at pro-oestrus being different from the other stages.6. Following perfusion with [14C]oleic acid (which is not a substrate for cyclooxygenase), variations in the distribution of label in radioactivity in lung were also observed. However, these were not related to the stages of the oestrous cycle in the same way as those associated with arachidonic acid.7. We conclude that both pathways of arachidonic acid metabolism in lungoxidation via cyclo-oxygenase and incorporation into phospholipid -are affected by the progress of the oestrous cycle.8. Altered arachidonate metabolism appeared to be associated chiefly with prooestrus and may be linked to those hormones involved in this stage of the oestrous cycle.

show abstract

Prostaglandin synthesis by murine mammary gland is modified by the state of the estrus cycle

Cited by 5 publications

References 21 publications

Gangliosides, copper ions and angiogenic capacity of adult tissues

Gangliosides, copper ions and angiogenic capacity of adult tissues

Tumor-associated prostaglandins in patients with primary breast cancer: Relationship to clinical parameters

Effects of the oestrous cycle on the metabolism of arachidonic acid in rat isolated lung.

Contact Info

Product

Resources

About