Prostaglandin Release After Low-Energy Femtosecond Laser-Assisted Cataract Surgery Without Anti-Inflammatory Drug Premedication

Abstract

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Cataract Grade and Pupil: Comparison Between Conventional Phacoemulsification and Low-Energy Femtosecond Laser Assisted Cataract Surgery

“…Furthermore, the absence of preoperative anti-inflammatory drugs, as established in the authors' protocol in other studies, 12 did not reflect on pupil constriction, also corroborated by recent published articles. 23 Cataract grade influences the energy level of ultrasound energy employed, according to the literature. 15,24 The impact of higher levels of energy (for harder cataracts) may be accountable for pupillary constriction, by means of the stimulated release of inflammatory mediators.…”

“…Furthermore, the absence of preoperative anti-inflammatory drugs, as established in the authors’ protocol in other studies, 12 did not reflect on pupil constriction, also corroborated by recent published articles. 23 …”

Surgical time and efficacy of illuminated chopper-assisted cataract surgery involving miosis after femtosecond laser pretreatment

“…[3][4][5] Moreover, the low-energy pulses delivered at high frequencies by the LDV Z8 femtosecond laser system did not induce clinically significant prostaglandin release into the aqueous humor and no significant pupillary constriction. [7][8][9] In low-energy FLACS with a preoperative NSAID treatment, however, a decrease in the pupil size was still observed, and approximately 7 (20%) of the 35 patients had clinically significant miosis. 10 In our study using the low-energy femtosecond laser system without a NSAID pretreatment, 20 (6%) of the 336 patients had intraoperative miosis as well.…”

“…[4][5][6] Recently, low-energy FLACS has been introduced for the prevention of miosis induced by prostaglandin release after femtosecond laser procedures. [7][8][9] However, significant miosis still occurs at a constant rate even with a NSAID pretreatment or a low-energy FLACS. 10 In terms of surgical time, complexity, and iris manipulation, mechanical pupil dilation is not the first-line treatment.…”

A randomised AI-supported long-term evaluation of a layer-by-layer macular thickness profile after manual and femtosecond laser cataract surgery

“…[1][2][3][4] In ammatory mediators like prostaglandins, cytokines, interleukins, and growth factors are known to be released from the anterior lens epithelial cells (antLEC) and the anterior uveal tissue induced by surgical trauma of cataract surgery, stimulating the breakdown of the blood-retinal-barrier (BRB) and subsequent leakage of uids through the retinal vessel-wall to the perifoveal retinal tissues. 2,[4][5][6][7][8] This postoperative in ammation induces the development of CME, indicating a conversion of the retinal layer manifesting as cystic changes and deterioration of visual acuity. CME recurs in a predictable pattern, beginning with cystic changes in the inner nuclear layer (INL), progressing to combined INL and outer nuclear layer (ONL) morphology, and may continue to involve subretinal uid.…”