Prostaglandin F2α regulation and function during ovulation and luteinization in cows

Moraes, Fabiane Pereira de; D'Avila, Camila Amaral; Oliveira, Fernando Caetano de; Castro, Natália Ávila de; Vieira, Arnaldo Diniz; Schneider, Augusto; Pfeifer, Luiz Francisco Machado; Pegoraro, L. M. C.; Ferreira, Rogério; Ferst, Juliana Germano; Rovani, Monique Tomazele; Corrêa, Márcio Nunes; Gonçalves, Paulo Bayard Dias; Lucia, Thomaz; Gasperin, Bernardo Garziera

doi:10.1016/j.theriogenology.2021.05.008

Cited by 8 publications

(11 citation statements)

References 39 publications

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“…Therefore, COX inhibitors influence all subsequently synthesized prostaglandins and thromboxanes. A differential effect on other important prostaglandins in the ovulation process, such as PGF 2α [ 45 , 48 ], cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

“…Prostaglandins play an important role in ovulation. In particular, prostaglandin E 2 (PGE 2 ) and prostaglandin F 2α (PGF 2α ) concentrations increase massively prior to ovulation [ 8 , 11 ]. Although the concentration of several prostaglandins increases in parallel during ovulation, PGE 2 is considered the key mediator [ 8 , 11 , 12 , 13 ].…”

mentioning

confidence: 99%

“…In particular, prostaglandin E 2 (PGE 2 ) and prostaglandin F 2α (PGF 2α ) concentrations increase massively prior to ovulation [ 8 , 11 ]. Although the concentration of several prostaglandins increases in parallel during ovulation, PGE 2 is considered the key mediator [ 8 , 11 , 12 , 13 ]. PGE 2 orchestrates ovulation processes, including cumulus expansion, oocyte release, follicle rupture, and angiogenesis, via its four receptor types, which are all present in the ovary [ 12 , 14 , 15 ].…”

mentioning

confidence: 99%

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Effects of different cyclooxygenase inhibitors on prostaglandin E2 production, steroidogenesis and ovulation of bovine preovulatory follicles

Vernunft

Lapp

Viergutz

et al. 2022

Journal of Reproduction and Development

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Ovulation is an inflammation-like process, and cyclooxygenase-2 (COX-2)-dependent production of prostaglandin E 2 (PGE 2 ) is its key mediator. Balanced regulation of inflammatory processes in high-yielding dairy cows may be essential for physiological ovulation and fertility. This study aimed to elucidate the mechanisms underlying ovulation failure and cyst development after disturbing intrafollicular inflammatory cascades. Therefore, nonselective (indomethacin and flunixin-meglumine), COX-2 selective (meloxicam), and highly COX-2 selective (NS-398) inhibitors were injected into preovulatory follicles 16 h after administration of GnRH, and ovulation was monitored via ultrasound examination. Additionally, follicular fluid was collected after injection of indomethacin, meloxicam, and NS-398. Moreover, primary granulosa cell cultures from preovulatory follicles were prepared and treated with indomethacin, meloxicam, and NS-398. The concentrations of 17β-estradiol, progesterone, and prostaglandin E 2 (PGE 2 ) in the follicular fluid and cell supernatant were estimated. Indomethacin and flunixin-meglumine blocked ovulation, even at low doses, and led to ovarian cyst development. The selective and highly selective COX-2 inhibitors meloxicam and NS-398 were not effective in blocking ovulation. However, indomethacin, meloxicam, and NS-398 significantly and comparably reduced PGE 2 concentration in vivo and in vitro (P < 0.05) but had no effect on estradiol or progesterone production. This may contradict the generally accepted hypothesis that PGE 2 is a key mediator of ovulation and progesterone production. Our results suggest a connection between ovarian disorders and inflammatory actions in early postpartum cows.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Effects of different cyclooxygenase inhibitors on prostaglandin E2 production, steroidogenesis and ovulation of bovine preovulatory follicles

Vernunft

Lapp

Viergutz

et al. 2022

Journal of Reproduction and Development

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“…Insights into the effects of PGF 2α on ovulation have been recently reported. Intrafollicular injection of PGF 2α into pre-ovulatory follicles did not influence the time of ovulation, indicating that PGF 2α alone is not able to induce ovulation locally [ 43 ]. These results suggest that inducing LH release via a luteolysis-independent mechanism might be the main mechanism of PGF 2α in the ovulation process [ 44 , 45 ].…”

Section: Improvement Of Fertilization With Pgf 2αmentioning

confidence: 99%

Ovarian response to prostaglandin F2α in lactating dairy cows: A clinical update

López‐Gatius

2022

Journal of Reproduction and Development

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Prostaglandin F2α (PGF2α) and its analogs are used to induce luteolysis in estrus synchronization programs to terminate unwanted pregnancies or to promote ovulation in certain cow subpopulations. In the past few decades, the luteolytic dose of PGF2α has remained unchanged. This review explores the clinical implications of increasing the standard dose for these applications in high-producing dairy cows. Ultrasonography may assist in selecting the most appropriate PGF2α dose and improve the results. A reference has been used for PGF2α for promoting ovulation in herds showing poor reproductive performance.

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“…Similarly, in cattle, estrus cycle length in FM treated cows was not different from the estrus cycle length in the control group (20 vs. 22 days, respectively) [ 23 ]. The most recent studies prove that intramuscular FM treatment in cows had an inhibitory effect on the PGF synthesis within the follicle [ 24 ].…”

Section: Nonsteroidal Anti-inflammatory Drugsmentioning

confidence: 99%

A Critical Overview on Prostaglandin Inhibitors and Their Influence on Pregnancy Results after Insemination and Embryo Transfer in Cows

Jaśkowski

Opałka

Gehrke

et al. 2021

Animals

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Assisted reproductive techniques in cattle, such as artificial insemination (AI) and embryo transfer (ET), are widely used. Despite many years of methodological improvements, the pregnancy rate (PR) in cows has not increased in direct proportion with their development. Among the possibilities to increase the PR is the use of certain steroids and nonsteroidal anti-inflammatory drugs (NSAIDs). The antiluteolytic effect of NSAIDs is achieved by blocking cyclooxygenase, which is involved in the conversion of arachidonic acid to prostaglandins. This article compares the PRs obtained after treatment with the commonly used NSAIDs in cattle, including flunixin meglumine, carprofen, meloxicam, ibuprofen, aspirin, and sildenafil. Studies on the effectiveness of certain steroid drugs on the PR have also been described. The results were not always consistent, and so comparisons between studies were made. In conclusion, flunixin meglumine seems to be an option, and can be recommended for improving ET results, especially in situations of high exposure or susceptibility to stress. Its administration under all circumstances, however, might be pointless and will not lead to the desired effect.

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Prostaglandin F2α regulation and function during ovulation and luteinization in cows

Cited by 8 publications

References 39 publications

Effects of different cyclooxygenase inhibitors on prostaglandin E<sub>2</sub> production, steroidogenesis and ovulation of bovine preovulatory follicles

Effects of different cyclooxygenase inhibitors on prostaglandin E<sub>2</sub> production, steroidogenesis and ovulation of bovine preovulatory follicles

Ovarian response to prostaglandin F<sub>2α</sub> in lactating dairy cows: A clinical update

A Critical Overview on Prostaglandin Inhibitors and Their Influence on Pregnancy Results after Insemination and Embryo Transfer in Cows

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