Prostaglandin endoperoxides IV. Effects on smooth muscle

Hámberg, Mats; Hedqvist, Per; Strandberg, Kjell; Svensson, Jan; Samuelsson, Bengt

doi:10.1016/0024-3205(75)90266-0

Cited by 197 publications

(86 citation statements)

References 8 publications

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“…and PGH2 in causing contraction of the rat fundus (13,14), and PGF2a, that arachidonic acid, in doses up to concentration used in present investigation, PGE2 and PGF2a contract rat stomach fundus through stimulation of a common receptor (7). In present study, the aspirin-like drugs did not significantly antagonize the PGE2 and PGF2a-induced contraction of the rat fundus, indicating that the inhibition by the aspirin-like drugs of the arachidonic acid-induced contraction is not caused at the receptor site.…”

Section: Discussionmentioning

confidence: 90%

“…shown that the endoperoxides are 7 to 9 times more potent than PGF2a in causing contraction of the guinea pig trachea (13). In the light of these findings, the bronchoconstriction induced by bradykinin is considered to be due mainly to TXA2 and the endoperoxides.…”

Section: Discussionmentioning

confidence: 97%

“…Arachidonic acid is now known to be converted by cyclo-oxygenase of the PG synthetase system to the PG endo peroxides PGG2 and PGH2 (10,11,12), precursors of PGE2 and PGF2a. The endoperoxides have contractile activity on the rat stomach fundus (13,14). However, they have recently been shown to be transformed almost exclusively to prostaglandin X (PGX) in rat stomach fundus (15,16), as in the arterial tissue of rabbits and pigs (16,17).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Studies on the Action Potential Originated From Nerve Elements in Guinea Pig Ureter

Yoshida

Kuga

1977

Japanese Journal of Pharmacology

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Studies on the Action Potential Originated From Nerve Elements in Guinea Pig Ureter

Yoshida

Kuga

1977

Japanese Journal of Pharmacology

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“…All prostanoids studied so far, including PGE1, PGF12,, PGA1, PGA2, PGG2 and TxA2, contract the longitudinal muscle of rat gastric fundus (Horton & Jones, 1969;1974;Hong, 1974;Hamberg, Hedqvist, Strandberg, Svensson & Samuelsson, 1975;Bunting, Moncada & Vane, 1976;Omini, Moncada & Vane, 1977). In the rabbit stomach longitudinal muscle, prostanoids also consistently cause contraction…”

Section: Discussionmentioning

confidence: 96%

Antagonism of Prostanoid‐induced Contractions of Rat Gastric Fundus Muscle by Sc‐19220, Sodium Meclofenamate, Indomethacin or Trimethoquinol

Bennett

Jarosik

Sanger

et al. 1980

British J Pharmacology

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3 The effect of the cyclo-oxygenase inhibitor sodium meclofenamate, 1 or 2 1tg/ml, on 6,15-diketo-PGFl, or thromboxane B2 was similar to the small antagonism of ACh, whereas the other prostanoids were blocked to greater extents. Indomethacin, 1 jig/ml, also reduced contractions to the prostanoids, but antagonism of the PGH2 epoxymethano analogues was considerably less than with meclofenamate. 4 The ,B-adrenoceptor stimulant trimethoquinol, 50 ng/ml, was the most potent prostanoid antagonist tested; all the prostanoids except PGE2 were antagonized more than ACh.

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“…This labile contracting material is a mixture of the unstable arachidonate metabolites, namely endoperoxides (PGG2 and PGH2) and thromboxane A2 (Hamberg, Svensson & Samuelsson, 1975). These unstable compounds are difficult to synthesize.…”

Section: Introductionmentioning

confidence: 99%

Effect of Gender on Development and Diurnal Rhythm of Prostaglandin Receptors in Rat Aorta

Karanian¹,

Ramey²,

Ramwell³

1981

British J Pharmacology

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1 The prostaglandin endoperoxide H2 analogue, U-46619 (15-hydroxy-11, 9-epoxymethanoprosta-5Z, 13E-enoic acid), was used to determine the effect of gender on the isotonic contractile response of the superfused rat aorta preparation over a 24 h period and at 10 and 16 weeks of age. 2 The maximal responses of the male aortae were 20 ± 3% and 36 ± 4% (P< 0.001) greater than the female at 10 and 16 weeks, respectively. Similarly, sensitivity of the male aorta to the PGH2 analogue increased with age. 3 The male but not the female exhibited a diurnal rhythm in which both the maximum contractile response and sensitivity were significantly decreased at night. 4 We conclude that these gender differences may be related to the secretion of androgen, since reported peak serum testosterone over a 24 h period and testosterone changes with maturation are coincident with the maximum response of male aortae to the PGH2 analogue.

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Prostaglandin endoperoxides IV. Effects on smooth muscle

Cited by 197 publications

References 8 publications

Studies on the Action Potential Originated From Nerve Elements in Guinea Pig Ureter

Studies on the Action Potential Originated From Nerve Elements in Guinea Pig Ureter

Antagonism of Prostanoid‐induced Contractions of Rat Gastric Fundus Muscle by Sc‐19220, Sodium Meclofenamate, Indomethacin or Trimethoquinol

Effect of Gender on Development and Diurnal Rhythm of Prostaglandin Receptors in Rat Aorta

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