Studies on the Action Potential Originated From Nerve Elements in Guinea Pig Ureter

Yoshida, Soichi; Kuga, Tetsurō

doi:10.1254/jjp.27.889

Cited by 11 publications

(9 citation statements)

References 22 publications

(17 reference statements)

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“…The findings that indomethacin and as pirin were more potent than ibuprofen and phenylbutazone agree with those reported by Piper and Vane [1979], However, these re sults are not in accordance with those of Ono et al [ 1977] who reported that aspirin was the least potent of the agents tested for inhibition of bradykinin-induced bronchospasm.…”

Section: Discussionsupporting

confidence: 70%

“…1975], Similar to other nonsteroidal anti-inflammatorydrugs (NSAIDs), meseclazone and 5-CSA in hibit both secondary phase ADP-induced and collagen-induced aggregation in vitro [Diamantis et al, 1978], Furthermore, mese clazone, 5-CSA and other NSAIDs have been shown to cause relaxation of the isolated guinea pig tracheal chain [Diamantis et al. 1979], This effect of NSAIDs has been as cribed to their inhibition of intramural bio synthesis of prostaglandin endoperoxides [Ono et al, 1977],…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antagonism by Meseclazone and Other Nonsteroidal Anti-Inflammatory Drugs of Bradykinin-Induced Bronchospasm

Diamantis¹,

Je²,

Jl³

et al. 1982

Pharmacology

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Bradykinin-induced bronchoconstriction is due, in part, to release of TXA₂ and prostaglandins. Intravenous administration of meseclazone and other nonsteroidal anti-inflammatory drugs caused a dose-dependent inhibition of bronchoconstriction resulting in the following order of descending potency: isoproterenol ≈ indomethacin > fenoprofen > tolmetin > aspirin > naproxen ≃ ibuprofen > phenylbutazone > diflunisal > meseclazone > 5-CSA. This order of potency does not correlate with that obtained with these compounds for in vitro relaxation of tracheal smooth muscle, an effect which may be related to inhibition of prostaglandin synthesis.

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Section: Discussionsupporting

confidence: 70%

Section: Introductionmentioning

confidence: 99%

Antagonism by Meseclazone and Other Nonsteroidal Anti-Inflammatory Drugs of Bradykinin-Induced Bronchospasm

Diamantis¹,

Je²,

Jl³

et al. 1982

Pharmacology

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“…In guinea-pig tracheal chains, the ED50 for inhibition ofintrinsic tone by indomethacin is about 10-6 M (Farmer et al, 1972) or slightly less (Ono et al, 1977). In contrast, in bullfrog hemilungs 10-5 M indomethacin produced only a small effect (9% of Imax).…”

Section: Indomethacinmentioning

confidence: 99%

“…Except for studies relating intrinsic tone to prostaglandin synthesis, the mechanisms underlying intrinsic tone are obscure. In the guinea-pig tracheal muscle, synthesis of stimulant prostaglandins appears to be responsible for a large fraction of the high intrinsic tone, and indomethacin causes profound relaxation (Farmer et al, 1972;Orehek et al, 1973;1975;Ono et al, 1977), presumably by inhibition of the cyclo-oxygenase pathway. In contrast, indomethacin does not relax human bronchial preparations (Brink et al, 1980;Hutas et al, 1981), suggesting 'that the regulatory role of prostanoids in human airway muscle may be less than in other species' (Brink et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of intrinsic tone in bullfrog lung: relaxant effects of indomethacin, ouabain and potassium

Downes

Edelstein

Taylor

1986

British J Pharmacology

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1 Bullfrog hemilungs showed minimal relaxation (9 ± 2% of the maximal relaxant effect of theophylline, Imax) after a 16 h incubation in 10-0M indomethacin, indicating that prostaglandin synthesis plays little or no role in the high intrinsic tone characteristic of this preparation.2 A higher concentration of indomethacin (10-4 M) produced greater relaxation (23 ± 3% of Imax), but also markedly potentiated isoprenaline-induced relaxation. The interaction with isoprenaline was similar to that previously found for papaverine, a phosphodiesterase inhibitor.3 Ouabain (l0' and 10-4 M) produced an initial contraction followed by marked relaxation (50% of Imax), indicating that a ouabain-sensitive mechanism is of major importance in the maintenance of intrinsic tone. 4 Ouabain-treated hemilungs showed (a) reversal (relaxation) of the normal contractile response to 26mM potassium and (b) marked impairment of the contractile response to calcium in calciumdepleted preparations. These effects suggest that ouabain-induced relaxation reflects a drug action on calcium movements. 5 The marked relaxation (30 to 40% of Imax) produced by 26mM potassium in ouabain-treated hemilungs is of particular interest in that it indicates a mechanism of potassium-induced relaxation distinct from stimulation of sodium-potassium ATPase.

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“…Our previous report (3) showed that relatively low doses of aspirin-like drugs reduced dose-dependently the resting tonus of the isolated guinea-pig tracheal chain, and that there was a highly significant correlation between the degree of relaxation of the tracheal chain and the inhibitory effect on the contraction of the isolated rat stomach induced by arachidonic acid, a precursor of PGs. The antagonistic effect of aspirin-like drugs against arachidonic acid was considered to be due to inhibition of PG biosynthesis since the drugs had no direct antagonistic effect against PGs in the rat stomach fundus strips (3).…”

mentioning

confidence: 95%

Interaction between aspirin and prostaglandins in the isolated guinea-pig tracheal muscle.

Ono¹,

Motoyama²,

Sakai³

et al. 1979

Jpn.J.Pharmacol

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Abstract-The effects of PGE2 and PGF2a on the tonus of isolated guinea-pig tracheal chain were investigated and compared with those of histamine and acetylcholine.PGE2 reduced tonus in normal resting state, but elevated tracheal tonus reduced by aspirin. Such PGE2-induced contractions did not exceed the initial resting tonus, and the magnitude and duration of the contractions progressively diminished with increase of PGE2 concentrations. Aspirin produced neither relaxation nor contraction in the presence of a low dose of PGE2.Unlike PGE2, PGF2a produced a dose-related contraction in the normal tracheal chain, and the contractile response to PGF2a was markedly potentiated by aspirin.In the presence of PGF2a, aspirin no longer produced tracheal relaxation but produced a dose-related contraction. The contractile effect of histamine but not of acetylcholine was also potentiated by aspirin, but there was a slight difference between PGF2a and histamine in that the potentiation of action of PGF2a by aspirin was more easily diminished by PGE2. These results suggest that PGE2 plays an important role in the maintenance of the resting tonus of the isolated guinea-pig tracheal chain, and in large doses it also acts as a tracheal relaxant and attenuates the tracheal responses to PGF2a and histamine.Aspirin-like drugs have been shown to inhibit prostaglandin (PG) biosynthesis in some 30 different systems (1, 2). Our previous report (3) showed that relatively low doses of aspirin-like drugs reduced dose-dependently the resting tonus of the isolated guinea-pig tracheal chain, and that there was a highly significant correlation between the degree of relaxation of the tracheal chain and the inhibitory effect on the contraction of the isolated rat stomach induced by arachidonic acid, a precursor of PGs. The antagonistic effect of aspirin-like drugs against arachidonic acid was considered to be due to inhibition of PG biosynthesis since the drugs had no direct antagonistic effect against PGs in the rat stomach fundus strips (3). The results suggest that the inhibition of PG biosynthesis may be re sponsible for the relaxation of the isolated guinea-pig tracheal chain.

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Studies on the Action Potential Originated From Nerve Elements in Guinea Pig Ureter

Cited by 11 publications

References 22 publications

Antagonism by Meseclazone and Other Nonsteroidal Anti-Inflammatory Drugs of Bradykinin-Induced Bronchospasm

Antagonism by Meseclazone and Other Nonsteroidal Anti-Inflammatory Drugs of Bradykinin-Induced Bronchospasm

Mechanisms of intrinsic tone in bullfrog lung: relaxant effects of indomethacin, ouabain and potassium

Interaction between aspirin and prostaglandins in the isolated guinea-pig tracheal muscle.

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