Prostaglandin ‐ E <sub>2</sub> Levels in the Saliva of Common Migrainous Women

Vardi, J.; Flechter, Shlomo; Alguati, A.; Regev, I.; Ayalon, D.

doi:10.1111/j.1526-4610.1983.hed2302059.x

Cited by 24 publications

(16 citation statements)

References 7 publications

(18 reference statements)

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“…The increase observed in PGE 2 during migraine attacks matches similar experience with this eicosanoid in migraine. 17 In relation to TXA 2 , our results are in the same order of magnitude as those obtained in the plasma of migraine patients. 18 No data were found on TXA 2 levels in saliva.…”

Section: Resultssupporting

confidence: 83%

Increase in PGE₂ and TXA₂ in the Saliva of Common Migraine Patients. Action of Calcium Channel Blockers

1989

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PGE2 and TXA2 levels and their modulation by nicardipine, a calcium blocking agent, have been studied in patients suffering from migraine. The levels of both metabolites were determined in saliva obtained during the migraine attacks, during the intervals between attacks, and after 2 months of treatment with nicardipine (20 mg every 8 h.) or placebo. The therapeutic response was evaluated on the basis of the number of migraine attacks. The results show a significant increase in the levels of both eicosanoids during the migraine attacks. In contrast to the placebo group, the number of migraine attacks and the levels of both arachidonic acid metabolites are markedly lower in the nicardipine group. Our results suggest calcium entry into the cytosol as an explanation for the increase in PGE2 and TXA2. Nicardipine interferes with calcium mobilization, thereby inhibiting arachidonic acid metabolite synthesis.

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Section: Resultssupporting

confidence: 83%

Increase in PGE₂ and TXA₂ in the Saliva of Common Migraine Patients. Action of Calcium Channel Blockers

1989

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“…The present study indicated that nasal lavage and saliva levels of LTB 4 were significantly lower and PGE 2 and TXB 2 levels did not differ significantly in migraineurs and controls during the headache‐free interval. Similar results were observed by Vardi et al who demonstrated that PGE 2 levels in the saliva of migraineurs were not significantly different from the controls 16 . However, another study showed lower levels of PGE 2 in migraineurs compared with controls 12 .…”

Section: Commentssupporting

confidence: 88%

“…However, future studies are needed to investigate whether the peripheral level of inflammatory mediators could be an indicator of an impending migraine attack. It has been demonstrated that the presence of inflammatory mediators such as prostaglandins and leukotrienes in plasma as well as in saliva during the migraine attack play a trigger role in migraine 11,12,16,21 …”

Section: Commentsmentioning

confidence: 99%

Peripheral Levels of Inflammatory Mediators in Migraineurs During Headache‐free Periods

et al. 2001

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Objectives.-The present study investigated the peripheral inflammatory changes of the trigeminovascular system by measuring the inflammatory mediators leukotriene B 4 (LTB 4 ), prostaglandin E 2 (PGE 2 ), and thromboxane B 2 (TXB 2 ) in the nasal fluid, as well as saliva, of patients with migraine.Background.-Migraine has been hypothesized to be as a result of changes in the peripheral or central nervous system or both. It is still unclear whether peripheral changes in the trigeminovascular system are involved in the pathogenesis of migraine.Methods.-Participants were 18 subjects, 9 patients with migraine and 9 controls, matched for age and sex. Each subject took part in one experimental session during which nasal lavage fluid and saliva samples were collected. These samples were analyzed by competitive enzyme immunoassay using goat anti-rabbit polyclonal antibody.Results.-With the exception of TXB 2 , correlational analyses indicated good correlations between results obtained using nasal lavage or saliva (LTB 4 , r 18 ϭ 0.91; PGE 2 , r 18 ϭ 0.95). When comparing inflammatory mediators measured in controls and migraineurs, the LTB 4 level was significantly lower in migraineurs, while no differences were found for PGE 2 and TXB 2 .Conclusions.-The study demonstrated that nasal lavage, a noninvasive method, can be easily used for investigations of pathophysiological mechanisms of migraine. In addition, the results may indicate that there is no peripheral trigeminal sensitization in the headache-free period of migraineurs compared with controls when PGE 2 , LTB 4 , and TXB 2 in saliva and nasal lavage samples are measured.

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“…In 1983, Vardi et al 11 sought the presence of PGE 2 in the saliva of women suffering from common migraine and in that of controls. In 1981, Amroyan 9 studied migraine patients between attacks and during attacks and found PGE 2 levels three times and six times higher, respectively, than those in controls.…”

Section: Introductionmentioning

confidence: 99%

Treatment Review: Non‐Steroid Anti‐Inflammatory Drugs in the Treatment and Long‐Term Prevention of Migraine Attacks

Pradalier¹,

Clapin²,

J³

1988

Headache

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SYNOPSIS After reviewing the pathophysiological features suggesting a role of prostaglandins in migraine, we have analyzed the literature concerning double‐blind trials of anti‐inflammatory drugs versus placebo or reference compounds in the acute and long‐term preventive treatment of migraine. For both of these indications, in the majority of double‐blind trials NSAID's have been found to be superior to placebo and equivalent to reference drugs. Certain points remain to be defined including, in particular, the following: • acceptability in the long‐term or by frequent repeated administrations, • efficacy according to different types or factors inducing migraine. More extensive trials are therefore indicated.

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Prostaglandin ‐ E ₂ Levels in the Saliva of Common Migrainous Women

Cited by 24 publications

References 7 publications

Increase in PGE₂ and TXA₂ in the Saliva of Common Migraine Patients. Action of Calcium Channel Blockers

Increase in PGE₂ and TXA₂ in the Saliva of Common Migraine Patients. Action of Calcium Channel Blockers

Peripheral Levels of Inflammatory Mediators in Migraineurs During Headache‐free Periods

Treatment Review: Non‐Steroid Anti‐Inflammatory Drugs in the Treatment and Long‐Term Prevention of Migraine Attacks

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Prostaglandin ‐ E 2 Levels in the Saliva of Common Migrainous Women

Cited by 24 publications

References 7 publications

Increase in PGE2 and TXA2 in the Saliva of Common Migraine Patients. Action of Calcium Channel Blockers

Increase in PGE2 and TXA2 in the Saliva of Common Migraine Patients. Action of Calcium Channel Blockers

Peripheral Levels of Inflammatory Mediators in Migraineurs During Headache‐free Periods

Treatment Review: Non‐Steroid Anti‐Inflammatory Drugs in the Treatment and Long‐Term Prevention of Migraine Attacks

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Product

Resources

About

Prostaglandin ‐ E ₂ Levels in the Saliva of Common Migrainous Women

Increase in PGE₂ and TXA₂ in the Saliva of Common Migraine Patients. Action of Calcium Channel Blockers

Increase in PGE₂ and TXA₂ in the Saliva of Common Migraine Patients. Action of Calcium Channel Blockers