2018
DOI: 10.1016/j.bjm.2017.12.010
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Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus

Abstract: Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 μg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10 μg/mL).

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Cited by 6 publications
(5 citation statements)
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“…Nevertheless, we could not unambiguously identify viral particles in placentae from COVID-19 pregnant women. Drastic cytoplasm vacuolization that we reported in SARS-CoV-2 trophoblast cells was previously described in an in vitro model of human conducting airway epithelium and Madin-Darby bovine kidney cells for SARS-CoV [51,52] leading to the hypothesis that vacuoles, in terms of early and late endosomes, could have a key role in the virus assembly process [53]. Accordingly, it was recently proposed that the downregulation of Rab7 small GTPase protein found in placentae from COVID-19 pregnant women could result in retention of the virus in the early endosomes or trapping within late endosomes and MVB, mediating physiological placental blockade of SARS-CoV-2 in pregnancy and consequently its vertical transmission.…”
Section: Discussionsupporting
confidence: 66%
“…Nevertheless, we could not unambiguously identify viral particles in placentae from COVID-19 pregnant women. Drastic cytoplasm vacuolization that we reported in SARS-CoV-2 trophoblast cells was previously described in an in vitro model of human conducting airway epithelium and Madin-Darby bovine kidney cells for SARS-CoV [51,52] leading to the hypothesis that vacuoles, in terms of early and late endosomes, could have a key role in the virus assembly process [53]. Accordingly, it was recently proposed that the downregulation of Rab7 small GTPase protein found in placentae from COVID-19 pregnant women could result in retention of the virus in the early endosomes or trapping within late endosomes and MVB, mediating physiological placental blockade of SARS-CoV-2 in pregnancy and consequently its vertical transmission.…”
Section: Discussionsupporting
confidence: 66%
“…3A). Drastic vacuolization due to viral infection was previously described for other RNA viruses including SARS-CoV [20,31]. Similar sites were recently reported as virus morphogenesis matrix vesicae (VMMV) [19].…”
Section: Vacuoles Containing Viral Particlessupporting
confidence: 72%
“…3 A). Drastic vacuolization due to viral infection was previously described for other RNA viruses including SARS-CoV 20 , 32 . Similar sites were recently reported as virus morphogenesis matrix vesicae (VMMV) 19 .…”
Section: Discussionmentioning
confidence: 72%