Prospects on Nano-Based Platforms for Antimicrobial Photodynamic Therapy Against Oral Biofilms

Balhaddad, Abdulrahman A.; García, Isadora Martini; Ibrahim, Maria Salem; Rolim, Juliana Paiva Marques Lima; Gomes, Edison A.B.; Martinho, Frederico Canato; Collares, Fabrício Mezzomo; Xu, Hockin H.K.; Melo, Mary Anne S.

doi:10.1089/photob.2020.4815

Cited by 20 publications

(26 citation statements)

References 143 publications

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“…3 aPDT is a promising treatment for the eradication of microorganisms and has been shown to be effective against bacteria, viruses, fungi and parasites, as well as in the degradation of its external virulence factors. 6,12 Macêdo et al 12 published two case reports using aPDT in oral lesions in patients with leukemia, and they observed that aPDT had positive results and was well accepted by the patient, presenting an important adjuvant therapy to reduce the course of infectious lesions in cancer patients, as in the current clinical case.…”

Section: Discussionmentioning

confidence: 60%

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Antimicrobial Photodynamic Therapy for the Treatment of Alveolar Osteitis in a Patient With Acute Lymphoid Leukemia: A Case Report

Camilo-Silva

Melo²,

Moreira

et al. 2021

J Lasers Med Sci

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Introduction: Acute lymphoid leukemia (ALL) is a malignant disease, the prognosis of which depends on the age of the patient and the treatment. The aim of this article was to report the treatment of this rare and interesting case of alveolar osteitis with antimicrobial photodynamic therapy (aPDT) in a patient with ALL that was resolved efficiently and quickly. Case Presentation: A 33-year-old male diagnosed with ALL attended the public service, complaining of pain in the region of tooth 48, without function. Extraction was performed, and the patient returned for postoperative follow-up, complaining of severe pain in the area of the alveolus. Clinical examination revealed osteitis. The alveolus was treated using aPDT with 0.005% methylene blue photosensitizer, followed by the application of a low-level red laser at a wavelength of 660 nm (321 J/cm2 – site). After 15 days, soft tissue closure was observed and complete filling of the alveolus was observed radiographically with a 7-month follow-up. Conclusion: The authors suggest that aPDT can be an effective treatment of alveolar osteitis in a patient with ALL.

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Section: Discussionmentioning

confidence: 60%

“…5 With a specific mechanism of action, aPDT has an immediate advantage in microbial reduction. 6 There are few studies in the literature that treat simple tooth socket infections after extraction with aPDT. 7,8 A study carried out on humans showed beneficial results using a-PDT for the prevention of post-extraction alveolitis 7 .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Photodynamic Therapy for the Treatment of Alveolar Osteitis in a Patient With Acute Lymphoid Leukemia: A Case Report

Camilo-Silva

Melo²,

Moreira

et al. 2021

J Lasers Med Sci

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“…The 1 O 2 is highly electrophilic and can oxidize the double bonds in biological molecules. Thus it plays an important role in cell damage and death (Balhaddad et al, 2020; Dascǎlu et al, 2017; Diniz et al, 2015; X. Hu et al, 2018; Soukos & Goodson, 2011; Stájer et al, 2020). The working mechanism of the therapy has been illustrated in Figure 8.…”

Section: Strategies For Evasion Of Microbial Resistancementioning

confidence: 99%

mentioning

confidence: 99%

Strategies toward development of antimicrobial biomaterials for dental healthcare applications

Parhi

Pal

Das

et al. 2021

Biotech & Bioengineering

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Several approaches for elimination of oral pathogens are being explored at the present time since oral diseases remain prevalent affecting approximately 3.5 billion people worldwide. Need for antimicrobial biomaterials in dental healthcare include but is not restricted to designing resin composites and adhesives for prevention of dental caries. Constant efforts are also being made to develop antimicrobial strategies for clearance of endodontic space prior root canal treatment and for treatment of periimplantitis and periodontitis. This article discusses various conventional | © 2021 Wiley Periodicals LLC Microorganisms Type of disease References Lactobacilli Dental caries Caufield et al. (2015) (Mutans streptococci) Streptococcus mutans, Streptococcus sorbinus Dianawati et al. (2020) Aggregatibacter actinomycetemcomitans Periodontitis Oscarsson et al. (2019) Porphyromonas gingivalis Z. He et al. (2020) Fusobacterium nucleatum Endodontic infection Martinho et al. (2016); Matsui et al. (2014) Enterococcus faecalis Alghamdi and Shakir (2020)

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“…One of the significant benefits of aPDT is its reliance on enhanced penetration and accessibility of oxygen species [38,39] Type II: Light activates the PS, which then reacts on molecular oxygen with in ground state so create excited state oxygen. ( 1 O 2 ), which seems directly impacted by biofilm-related diseases [40].…”

Section: Antimicrobial Photodynamic Therapy (Apdt)mentioning

confidence: 99%

Application of Nanoparticles in Endodontics

Bute

Ikhar

Bhonde

et al. 2021

JPRI

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Nanoscience is a planned blend of nanotechnologies/nanoparticles used in healthcare to discover novel treatment strategies for human infections. N anotechnology is used in many aspects of our daily lives, including medical science. Nanostructures are employed in dental advances, diagnosis and treatment [2]. When compared to traditional materials, Nanoparticles was shown to have significantly superior adhesive plus surface properties. Nanotechnology’s practical implementation in endodontics has allows for new study in this domain.

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Prospects on Nano-Based Platforms for Antimicrobial Photodynamic Therapy Against Oral Biofilms

Cited by 20 publications

References 143 publications

Antimicrobial Photodynamic Therapy for the Treatment of Alveolar Osteitis in a Patient With Acute Lymphoid Leukemia: A Case Report

Antimicrobial Photodynamic Therapy for the Treatment of Alveolar Osteitis in a Patient With Acute Lymphoid Leukemia: A Case Report

Strategies toward development of antimicrobial biomaterials for dental healthcare applications

Application of Nanoparticles in Endodontics

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