Prospects of antimicrobial peptides application in otorhinolaryngology in conditions of increasing antibiotic resistance

Payganova, N E; Yastremsky, A. P.

doi:10.17116/otorino202186031104

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Antimicrobial Peptides (AMPs) are a class of small molecular peptides produced by the body to resist the invasion of pathogenic microorganisms when pathogenic microorganisms invade which have good inhibitory effect and are the first line of defense of the body's innate immune system and are resistant to most drug-resistant bacteria, viruses, fungi, etc (Payganova et al, 2021;Gumienna et al, 2021;Sahoo et al, 2021). Antimicrobial peptides have a wide range of sources, exist in most organisms, and can be isolated from insects, invertebrates, mammals, and even humans.…”

Section: Introductionmentioning

confidence: 99%

The function of antimicrobial peptide MPX on the apoptosis and barrier of IPEC-J2 cells

Zhao

2021

SMLNUVMB

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The porcine intestinal epithelial cell line IPEC-J2 cells, which were isolated from neonatal piglet mid-jejunum, the main components of the intestinal epithelium and play an important role in the intestine. Escherichia coli is an important cause of diarrhea in human and animal. E.coli infections are the leading cause of travelers' diarrhea and a major cause of diarrhea in developing nations, where it can be life-threatening among children. The aim of this study is to explore MPX against E. coli to inhibit IPEC-J2 cells apoptosis and enhance cell barrier. In this study, scanning electron microscopy results found that E. coli infection caused cell apoptosis and destroyed cell membranes of IPEC-J2 cell. MPX effectively alleviated apoptosis of IPEC-J2 cells. The laser confocal results further found that MPX prevented cell apoptosis by inhibiting caspase-3 and caspase-9 activation. In addition, it was found that MPX regulated the expression of tight junction proteins ZO-1, Occludin, and Claudin-1 in IPEC-J2 cells and is closely related to Rac1 by adding a Rac1 inhibitor. The results of adhesion and invasion experiments further found that MPX inhibited bacterial adhesion and invasion through Rac1. The above results indicated that MPX has better function in inhibiting IPEC-J2 cells apoptosis and enhancing cell barrier.

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Section: Introductionmentioning

confidence: 99%

The function of antimicrobial peptide MPX on the apoptosis and barrier of IPEC-J2 cells

Zhao

2021

SMLNUVMB

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Possibilities of modern forms of antimicrobial peptides in the treatment of inflammatory pathology of the pharynx

Гуров¹,

Dubovaya²,

Ermolaev³

et al. 2022

Vestn. otorinolaringol.

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The use of combined drugs as a component of complex therapy of inflammatory diseases of the pharynx: A review

Kosyakov,

Pchelenok,

Usmanova

2024

Consilium Medicum

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Unfortunately, the occurrence of various pathologies in the ENT organs still remains one of the pressing problems in global healthcare. The frequent manifestation of unwanted pathologies forces us to change methods, and sometimes to introduce something new into the medical care provided to patients. Researchers from the Center for Medical Statistics of the Scientific Research Institute of Medical Sciences and Medical Research, Moscow Health Department, having conducted a detailed analysis of the activities of otorhinolaryngological departments in medical organizations in the city of Moscow, found that in 2022 the number of all visits to otorhinolaryngologists exceeded 4.5 million, of which 45.7% were children, and 54.2% were committed by persons over 18 years of age. Preventive visits of patients to doctors for 2018–2022 increased from 29.3 to 37.8%. Infectious and inflammatory diseases of the oral cavity and pharynx are among the most common diseases of the ENT organs. Given the proliferation, development of technology and possible tensions, they still remain a pressing issue. That is why various new options for drug therapy are being proposed that would be most effective, and one of these new drugs is Lorothricin, a combination drug that has shown itself to be the best in a number of studies and clinical cases. In a review article, based on our experience and literature data. We present the problem of treating patients with sore throat due to acute pharyngitis, tonsillitis and gingivitis.

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Prospects of antimicrobial peptides application in otorhinolaryngology in conditions of increasing antibiotic resistance

Cited by 3 publications

References 14 publications

The function of antimicrobial peptide MPX on the apoptosis and barrier of IPEC-J2 cells

The function of antimicrobial peptide MPX on the apoptosis and barrier of IPEC-J2 cells

Possibilities of modern forms of antimicrobial peptides in the treatment of inflammatory pathology of the pharynx

The use of combined drugs as a component of complex therapy of inflammatory diseases of the pharynx: A review

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