Prospects for Platelet-Rich Plasma Therapy in Pediatrics

Abstract

From the point of view of the characteristics of childhood and clinical and pathophysiological features of diseases in children, the injections of platelet-rich plasma (PRP) are an advantageous manipulation procedures characterized by minimal invasiveness, minimal risk of side effects, ease of obtaining material and manipulation technique, as well as the uselessness of anesthesia. The purpose of this research was to analyze the use and possible effectiveness of PRP therapy in pediatric practice and its application, in particular, in traumatology and orthopedics. The bibliographical search for the 2015 to 2022 sources was carried out using the electronic databases of scientific data in both Russian and English languages. In general, the PRP has a complex biological effect on regeneration, repair, and positive remodeling of connective tissue. Unfortunately, there is no sufficient experience worldwide in the use of PRP therapy in pediatrics, which makes it difficult to interpret the method, evaluate its effectiveness and indications for the use. In the authors’ opinion, the PRP therapy is very promising and of a great potential in pediatric traumatology and orthopedics, where it is important to combine it with additive technologies (kinesio taping, post-isometric relaxation etc.). The unresolved aspects of the pediatric PRP therapy call for pediatric practitioners of different schools to build an evidence database using both clinical observations and biological models.