Prospects for management of ischemia and reperfusion

Piccinato, Carlos Eli

doi:10.1590/1677-5449.1303

Cited by 1 publication

(1 citation statement)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This fact may be due to reperfusion injury, which occurs when oxygenated blood returns to the tissues leading to production of a number of reactive oxygen species (ROS) (Piccinato, 2014). Furthermore Pereira and Souza Junior (2013) showed that sedentary individuals produce greater amount of ROS after exercise than trained individuals.…”

Section: Discussionmentioning

confidence: 99%

The morphological and functional effects of exercise in the aquatic environment, performed before and/or after sciatic nerve compression in Wistar rats

Kakihata¹,

Malanotte²,

Karvat³

et al. 2016

J Exerc Rehabil

View full text Add to dashboard Cite

The aim of this study was to evaluate the effects of exercise in the aquatic environment, performed before and/or after sciatic nerve compression in Wistar rats on morphological and functional parameters. Twenty-five Wistar rats were divided into the following groups: control (C), lesion (L), trained+lesion (TL), lesion+exercise (LE), and training+lesion+exercise (TLE), who underwent right sciatic nerve compression on day 21 of the experiment. The TL and TLE groups were submitted to a jumping exercise in a water environment for 20 days prior to injury and the LE and TLE groups after injury. The functional analysis was carried out using the sciatic functional index (SFI). On the last day of the experiment, the right sciatic nerves were collected, processed and analysed according to morphology and morphometry. The C group showed higher SFI in relation to the other groups. In the morphometric analysis, in comparison to C, all groups showed a decrease in the diameter of the injured nerve fibre, the myelin sheath and an increase in the percentage of connective tissue. There was a decrease in axon diameter in L, TL, and LE groups and a decrease in the density of nerve fibres in the TL and LE groups. The exercise did not affect functional recovery. However, the exercise prior to the injury improved morphology of the nervous tissue, and when performed pre- and postinjury, there was also an improvement in nerve regeneration, but this was not the case with exercise performed after the injury demonstrating worse results.

show abstract

Section: Discussionmentioning

confidence: 99%