Prospects for controlling future pandemics of SARS in highlights of SARS-CoV-2

Basnet, Buddha Bahadur; Basnet, Rajesh; Panday, Raju

doi:10.1007/s13337-021-00715-1

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…The concern may, therefore, decrease as the pandemic continues to wane. The prospect of further pandemics [ 21 , 22 ] may, however, mean there will always be concern about immunosuppressive medication following gene therapy. Further research is needed to ascertain whether immunosuppression will remain a necessary feature of gene therapy or whether alternative strategies can be used.…”

Section: Discussionmentioning

confidence: 99%

Barriers to gene therapy, understanding the concerns people with haemophilia have: an exigency sub-study

Fletcher,

Jenner,

Holland

et al. 2024

Orphanet J Rare Dis

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Background Gene therapy has the potential to offer people with haemophilia (PwH) a life free from bleeding and the burden posed by current treatment regimens. To date, gene therapy has only been available in clinical trial settings, to PwH without pre-existing or historical factor inhibitors, significant concomitant liver damage or pre-existing neutralising antibodies to the adeno-associated viruses used to deliver the therapy. Thus, most PwH treated at centres not currently involved in gene therapy trials, either as a referral/follow-up centre or as a dosing centre, have been unable to access the therapy. This Exigency sub-study aims to gain a greater understanding of the opinions of PwH in the United Kingdom who have not had access to gene therapy: asking what they understand, what concerns they have, and whether they perceive any barriers preventing their access to gene therapy. Results Twenty-three PwH were approached; 14 consented, and one withdrew prior to interview. The mean age of the participants was 35.7 years (range 25–74 years). Eleven had haemophilia A and two haemophilia B. Two were treated with standard half-life factor products, five with extended half-life products, five with a FVIII mimetic and one with a clinical trial product. One family member (a participant's partner) was also interviewed. The participants identified four barriers to gene therapy: concerns about the process of gene therapy (Expectations), uncertainty about the results (outcomes), (Access) to treatment, and a lack of understanding about gene therapy (education). Conclusions This Exigency study subgroup sees gene therapy as a positive treatment development that promises an improved quality of life. For this participant group, four issues impact their decision to undergo gene therapy. If the promise of gene therapy is to be realised, these barriers need to be acknowledged and addressed by healthcare professionals, patient organisations, and gene therapy providers.

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Section: Discussionmentioning

confidence: 99%

Barriers to gene therapy, understanding the concerns people with haemophilia have: an exigency sub-study

Fletcher,

Jenner,

Holland

et al. 2024

Orphanet J Rare Dis

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Education system of Nepal: impacts and future perspectives of COVID-19 pandemic

Pal¹,

Basnet²,

Pant³

et al. 2021

Heliyon

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The academic sectors are badly affected by the COVID-19 pandemic globally. The studies regarding the implications of COVID-19 in education in Nepal were minimal, thus, this paper aims to highlight the impacts of the pandemic on the education sector of Nepal. It is revealed that the Nepalese academia has been facing problems due to lack of adequate and appropriate sustainable infrastructure for the online system, including skilled human resources. In addition, limited internet facilities in remote and rural areas were the other challenging tasks for virtual academic activities. Therefore, the concerned stakeholders should provide necessary services and appropriate strategies for virtual means of the education system to compensate the repercussion caused by the pandemic. This study could be helpful to identify the critical needs emerged due to the pandemic at present and in future and also contribute to adopt appropriate policy for the revival of educational institutions.

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SARS-CoV-2 origin, myths and diagnostic technology developments

Wambani

Okoth

2022

Egypt J Med Hum Genet

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Background After the first case of COVID-19 being announced in China in December 2019, various diagnostic technologies have been developed at unprecedented pace with the aim of providing a basis for accurate clinical intervention. However, some assays including CRISPR-based diagnostics and loop-mediated isothermal amplification (LAMP) have been less explored. As new COVID-19 technologies emerge, there is need for them to be assessed, validated and improved upon. Moreover, there is paucity of data on the essential factors governing the selection of an appropriate diagnostic approach within the correct timeframe. Myths and origin of SARS-CoV-2 remain to be controversial. Consequently, this review aims at exploring the current COVID-19 diagnostic technologies, performance evaluation, principles, suitability, specificity, sensitivity, successes and challenges of the technologies for laboratory and bedside testing. Main Body To date, there exist more publications on COVID-19 diagnostics as compared to the Zika virus. The SARS-CoV-2 virus genome profiles were readily available by 31st of December 2019. This was attributed to the fast-paced sharing of the epidemiological and diagnostics data of COVID-19. Timely profiling of the virus genome accelerated the development of diagnostic technologies. Furthermore, the rapid publication of studies that evaluated several diagnostic methods available provided baseline information on how the various technologies work and paved way for development of novel technologies. Conclusion Up to date, RT-PCR is the most preferred as compared to the other assays. This is despite the repeated false negatives reported in many of the study findings. Considering that COVID-19 has caused devastating effects on the economy, healthcare systems, agriculture and culture, timely and accurate detection of the virus is paramount in the provision of targeted therapy hence reducing chances of drug resistance, increased treatment costs and morbidity. However, information on the origin of SARS-CoV-2 still remains elusive. Furthermore, knowledge and perception of the patients toward management of SARS-CoV-2 are also paramount to proper diagnosis and management of the pandemic. Future implications of the misperceptions are that they may lead to increased non-compliance to SARS-CoV-2-related World Health Organization (WHO) policies and guidelines.

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Prospects for controlling future pandemics of SARS in highlights of SARS-CoV-2

Cited by 3 publications

References 14 publications

Barriers to gene therapy, understanding the concerns people with haemophilia have: an exigency sub-study

Barriers to gene therapy, understanding the concerns people with haemophilia have: an exigency sub-study

Education system of Nepal: impacts and future perspectives of COVID-19 pandemic

SARS-CoV-2 origin, myths and diagnostic technology developments

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