Prospective study of cosmetic reactions: 1977-1980

Eiermann, Heinz J.; Larsen, Walter G.; Maibach, Howard I.; Taylor, James S.; Adams, Robert M.; Clendenning, William E.; Fisher, Alexander A.; Jordan, Wendy; Kanof, H.; Rudner, Earl J.; Schorr, William F.; Storrs, Frances J.; Marzulli, F.N.; Greif, M.; Atkinson, J.T.; Mally, Z.W.

doi:10.1016/s0190-9622(82)70080-5

Cited by 188 publications

(74 citation statements)

References 2 publications

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“…As such, the types included in the cosmetic product are so diverse that the entire population would be contacted with the cosmetic products several times a day regularly. Over 5,000 types of substances, including 800 types or more natural substances, vehicle, fragrance and other compounds are found 4,7 . Most of the constituents are safe for consumers, but approximately 2% of consumers are reported to experience side effects [4][5][6]8 .…”

Section: Discussionmentioning

confidence: 99%

“…This study confirms that cosmetic series includes most preservatives found in marketed cosmetic products, except sodium benzoate and chlorphenesin, and through this, the cosmetic series is relatively well reflected for the preservative ingredient. Although fragrances frequently cause contact dermatitis 1,4,5,10 , cosmetic series does not include any fragrance other than benzyl salicylate, a fragrance solvent. Approximately 1∼4% of the general population is allergic to fragrances 16,17 .…”

Section: Discussionmentioning

confidence: 99%

“…Cases of causing the ACD by the use of hair and nail related product is known to be the next most frequently caused case after the case of causing by the skin care products [4][5][6]10,11 . The ingredients with the main cause of the contact dermatitis by this product are p-phenylendiamine and tosylamide formaldehyde resin.…”

Section: Discussionmentioning

confidence: 99%

“…Side effects secondary to cosmetic product use are mostly due to irritation 2 , but may also manifest in allergic contact dermatitis (ACD), photocontact dermatitis and exacerbation of existing skin diseases 3 . ACD accounts for less than 10% [4][5][6] of side effects reported. Cosmetic products are usually consisted of different chemical compounds, which render it difficult to determine the culprits in the event of contact dermatitis.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Marketed Cosmetic Products Constituents with the Antigens Included in Cosmetic-related Patch Test

et al. 2010

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Background: Currently, cosmetic series (Chemotechnique Diagnostics, Sweden) is the most widely used cosmeticrelated patch test in Korea. However, no studies have been conducted on how accurately it reflects the constituents of the cosmetics in Korea. Objective: We surveyed the constituents of various cosmetics and compare with the cosmetic series, to investigate whether it is accurate in determining allergic contact dermatitis caused by cosmetics sold in Korea. Methods: Cosmetics were classified into 11 categories and the survey was conducted on the constituents of 55 cosmetics, with 5 cosmetics in each category. The surveyed constituents were classified by chemical function and compared with the antigens of cosmetic series. Results: 155 constituents were found in 55 cosmetics, and 74 (47.7%) of constituents were included as antigen. Among them, only 20 constituents (27.0%) were included in cosmetic series. A significant number of constituents, such as fragrance, vehicle and surfactant were not included. Only 41.7% of antigens in cosmetic series were found to be in the cosmetics sampled. Conclusion: The constituents not included in the patch test but possess antigenicity are widely used in cosmetics. Therefore, the patch test should be modified to reflect ingredients in the marketed products that may stimulate allergies. (Ann Dermatol 22(3) 262∼268,

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparison of Marketed Cosmetic Products Constituents with the Antigens Included in Cosmetic-related Patch Test

et al. 2010

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“…174 -180 In a series of 487 patients with eczematous contact dermatitis, 4.5% were found to be sensitive to propylene glycol. 181 Oral or parenteral administration may exacerbate dermatitis in sensitized patients. 182,183 The high concentration of propylene glycol contained in certain drug products, such as phenytoin, diazepam, digoxin, and etomidate, may induce thrombophlebitis when administered intravenously.…”

Section: Propylene Glycolmentioning

confidence: 99%

“Inactive” Ingredients in Pharmaceutical Products: Update (Subject Review)

1997

Pediatrics

141

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ABSTRACT. Because of an increasing number of reports of adverse reactions associated with pharmaceutical excipients, in 1985 the Committee on Drugs issued a position statement 1 recommending that the Food and Drug Administration mandate labeling of over-thecounter and prescription formulations to include a qualitative list of inactive ingredients. However, labeling of inactive ingredients remains voluntary. Adverse reactions continue to be reported, although some are no longer considered clinically significant, and other new reactions have emerged. The original statement, therefore, has been updated and its information expanded.ABBREVIATIONS. FDA, Food and Drug Administration; MDIs, metered-dose inhalers Pharmaceutical products often contain agents that have a variety of purposes, including improvement of the appearance, bioavailability, stability, and palatability of the product. Excipients (substances added to confer a suitable consistency or form to a drug, such as the vehicle, preservatives, or stabilizers) frequently make up the majority of the mass or volume of oral and parenteral drug products. These pharmaceutical adjuvants are usually considered to be inert and do not add to or affect the intended action of the therapeutically active ingredients.Some 773 chemical agents have been approved by the Food and Drug Administration (FDA) for use as inactive ingredients in drug products.2 Inasmuch as these compounds are classified as "inactive," no regulatory statutes require listing on product labeling. Pharmacopeial guidelines, enforceable under the Food, Drug, and Cosmetic Act, do require labeling of inactive ingredients for topical, ophthalmic, and parenteral preparations; orally administered products are currently exempt. Because of pressure from professional and consumer organizations asking the FDA to require complete disclosure of all ingredients, voluntary labeling was adopted by the two major pharmaceutical industry trade associations. These voluntary guidelines contain an exemption for "trade secret" components and do not require complete disclosure of all fragrance and flavoring ingredients.Current problems encountered with "inactive" ingredients include benzalkonium chloride-induced bronchospasm from antiasthmatic drugs, aspartameinduced headache and seizures, saccharin-induced cross-sensitivity reactions in children with sulfonamide allergy, benzyl alcohol toxicity in neonates receiving high-dose continuous infusion with preserved medications, dye-related cross-reactions in children with aspirin intolerance, lactose-induced diarrhea, and propylene glycol-induced hyperosmolality and lactic acidosis. Although many other excipients have been implicated in causing adverse reactions, these are the most significant in the pediatric population. ANTIASTHMATIC MEDICATIONSIt is readily appreciated that some percentage of asthmatic children will develop a "paradoxical" bronchospasm after they inhale their medication. Because many of these reactions were attributed to sulfite, which had been highly publicized ...

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Benzylalkohol [MAK Value Documentation in German language, 2006]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 40. Lieferung, Ausgabe 2006 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Sonstige Wirkungen Bewertung

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Prospective study of cosmetic reactions: 1977-1980

Cited by 188 publications

References 2 publications

Comparison of Marketed Cosmetic Products Constituents with the Antigens Included in Cosmetic-related Patch Test

Comparison of Marketed Cosmetic Products Constituents with the Antigens Included in Cosmetic-related Patch Test

“Inactive” Ingredients in Pharmaceutical Products: Update (Subject Review)

Benzylalkohol [MAK Value Documentation in German language, 2006]

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