“…Biochemical studies have suggested that the polymorphic variant CX 3 CR1 I249/M280 exhibits defective adhesive properties, therefore leading to deficits in fractalkine signaling (Faure et al, ; McDermott et al, ). These variants have been associated with multiple neurodegenerative disorders such as age‐related macular degeneration (Chan, Tuo, Bojanowski, Csaky, & Green, ; Schaumberg et al, ), Alzheimer's disease (López‐López, Gelpi, Lopategui, & Vidal‐Taboada, ), and multiple sclerosis (Arli, Irkec, Menevse, Yilmaz, & Alp, ). Based on the evidence of enhanced neuronal damage in the cochlea of CX 3 CR1‐deficient mice, it would be of clinical relevance to dissect the effects of human reference CX 3 CR1 V249/T280 receptor and its polymorphic variant CX 3 CR1 I249/M280 in deaf ears.…”