Prospective Study of Air Pollution and Bronchitic Symptoms in Children with Asthma

McConnell, Rob; Berhane, Kiros; Gilliland, Frank D.; Molitor, John; Thomas, Duncan C.; Lurmann, Fred; Avol, Edward L.; Gauderman, W. James; Peters, John

doi:10.1164/rccm.200304-466oc

Cited by 175 publications

(124 citation statements)

References 44 publications

(45 reference statements)

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“…A California study of 19 predominantly white children found significant decrements in lung function (FEV 1 ) associated with indoor PM. While this study found associations between ambient PM and lung function, they found stronger associations for indoor than outdoor central site PM concentrations (18).…”

Section: Indoor Particulate Mattercontrasting

confidence: 80%

“…Previous investigators have indicated that exercise may play a role in asthma by modifying the effect of environmental stimuli and pollutants (18). Increased exercise symptoms in response to fine PM exposure may be attributable to increased minute ventilation and an increased dose of fine PM in the distal airways and the pulmonary circulation.…”

Section: Indoor Particulate Mattermentioning

confidence: 99%

See 1 more Smart Citation

Indoor Air Pollution and Asthma in Children

Breysse¹,

Diette²,

Matsui³

et al. 2010

Proceedings of the American Thoracic Society

175

108

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Section: Indoor Particulate Mattercontrasting

confidence: 80%

Section: Indoor Particulate Mattermentioning

confidence: 99%

Indoor Air Pollution and Asthma in Children

Breysse¹,

Diette²,

Matsui³

et al. 2010

Proceedings of the American Thoracic Society

175

108

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“…Previous statistical analyses of CHS data have utilized similar models to examine community-level effects (Berhane, Gauderman, Stram, & Thomas, in press;Gilliland, Berhane, Rappaport, Thomas, Avol, Gauderman et al, 2001;Hoffman, Gilliland, Eley, Harlan, Stephenson, Stanford et al, 2001;McConnell, Berhane, Gilliland, Molitor, Thomas, Lurmann et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

The association between contextual socioeconomic factors and prevalent asthma in a cohort of Southern California school children

Shankardass

McConnell

Milam

et al. 2007

Social Science & Medicine

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Spatial variation in childhood asthma and a recent increase in prevalence indicate that environmental factors play a significant role in the etiology of this important disease. Socioeconomic position (SEP) has been associated inversely and positively with childhood asthma. These contradictory results indicate a need for systematic research about SEP and asthma. Pathways have been suggested for effects of SEP on asthma at both the individual and community level. We examined the relationship of prevalent asthma to community-level indicators of SEP among 5762 children in 12 Southern California, using a multilevel random effects model. Estimates of community-level SEP were derived by summarizing census block group-level data using a novel method of weighting by the proportion of the block groups included in a community-specific bounding rectangle that contained 95% of local study subjects. Community © 2007 Elsevier Ltd. All rights reserved.Corresponding Author: shankard@usc.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript characteristics included measures of male unemployment, household income, low education (i.e. no high school diploma), and poverty. There was a consistent inverse association between male unemployment and asthma across the inter-quartile range of community unemployment rates, indicating that asthma rates increase as community SEP increases. The results were robust to individual-level confounding, methods for summarizing census block group data to the community level, scale of analysis (i.e. community-level vs. neighborhood-level) and the modeling algorithm. The positive association between SEP and prevalent childhood asthma might be explained by differential access to medical care that remains unmeasured, by the hygiene hypothesis (e.g. lower SES may associate with higher protective exposures to endotoxin in early life), or by SEP acting as a proxy for unmeasured neighborhood characteristics.

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“…Ambient pollutants, such as airborne particulate matter (PM) exposure, have been linked to more severe respiratory symptoms and decreased lung function among asthmatics, as well as increased mortality in the general population (Delfino et al, 2004;Mar et al, 2004;McConnell et al, 2003;Samet et al, 2000). It is notable that racial and ethnic minorities are more likely to live in the inner-city, where ambient PM concentrations are higher than in other more suburban settings (ALA Lung Disease Data in Culturally Diverse Communities, 2005).…”

Section: Introductionmentioning

confidence: 99%

Common household activities are associated with elevated particulate matter concentrations in bedrooms of inner-city Baltimore pre-school children

McCormack

Breysse

Hansel

et al. 2008

Environmental Research

104

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Asthma disproportionately affects inner-city, minority children in the U.S. Outdoor pollutant concentrations, including particulate matter (PM), are higher in inner-cities and contribute to childhood asthma morbidity. Although children spend the majority of time indoors, indoor PM exposures have been less extensively characterized. There is a public health imperative to characterize indoor sources of PM within this vulnerable population to enable effective intervention strategies. In the present study, we sought to identify determinants of indoor PM in homes of Baltimore inner-city pre-school children.Children ages 2-6 (n=300) who were predominantly African-American (90%) and from lower socioeconomic backgrounds were enrolled. Integrated PM 2.5 and PM 10 air sampling was conducted over a 3-day period in the children's bedrooms and at a central monitoring site while caregivers completed daily activity diaries. Homes of pre-school children in inner-city Baltimore had indoor PM concentrations that were twice as high as simultaneous outdoor concentrations. The mean indoor PM 2.5 and PM 10 concentrations were 39.5±34.5 μg/m 3 and 56.2±44.8 μg/m 3 , compared to the simultaneously measured ambient PM 2.5 and PM 10 (15.6±6.9 and 21.8±9.53 μg/m 3 , respectively). Common modifiable household activities, especially smoking and sweeping, contributed significantly to higher indoor PM, as did ambient PM concentrations. Open windows were associated with significantly lower indoor PM. Further investigation of the health effects of indoor PM exposure is warranted, as are studies to evaluate the efficacy of PM reduction strategies on asthma health of inner-city children.

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Prospective Study of Air Pollution and Bronchitic Symptoms in Children with Asthma

Cited by 175 publications

References 44 publications

Indoor Air Pollution and Asthma in Children

Indoor Air Pollution and Asthma in Children

The association between contextual socioeconomic factors and prevalent asthma in a cohort of Southern California school children

Common household activities are associated with elevated particulate matter concentrations in bedrooms of inner-city Baltimore pre-school children

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