Indoor Air Pollution and Asthma in Children

Breysse, Patrick N.; Diette, Gregory B.; Matsui, Elizabeth C.; Butz, Arlene; Hansel, Nadia N.; McCormack, Meredith C.

doi:10.1513/pats.200908-083rm

Cited by 182 publications

(125 citation statements)

References 33 publications

(38 reference statements)

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“…For example, in a previous study, every 10 mg/m 3 increase in indoor PM 2.5-10 concentration led to a 6% increase in the number of days of coughing, wheezing, or chest tightness, after adjusting for age, race, sex, socioeconomic status, season, indoor fine PM, and ambient fine and coarse PM concentrations (Breysse et al, 2010). This study also found that higher indoor coarse PM concentrations were also associated with increased incidences of symptoms severe enough to slow a child's activity, cause wheezing that limited speaking ability, nocturnal symptoms, and rescue medication use; and although outdoor coarse PM was not associated with increased asthma symptoms or rescue medication use, fine PM was positively associated with respiratory symptoms and rescue medication use (Breysse et al, 2010). These findings demonstrate that both indoor coarse and fine PM distinctly affect respiratory health in children with asthma.…”

Section: Adverse Effects Of Pm On Respiratory Diseases Identified In mentioning

confidence: 88%

“…Although fine PM may be capable of reaching the alveoli, the regions responsible for gas exchange, the deposition of coarse PM in upper airways and subsequent bronchial hyperreactivity may be responsible for the symptomatic response measured in preschool children (Breysse et al, 2010).…”

Section: Adverse Effects Of Pm On Respiratory Diseases Identified In mentioning

confidence: 99%

“…Indoor environmental factors thought to modify asthma severity include pollutants such as PM, nitrogen oxides, secondhand smoke, and allergens from pests, pets, and molds . In contrast to the outdoors, individuals have a greater ability to modify indoor environmental exposure risks, making indoor air pollution an attractive target for disease prevention (Breysse et al, 2010).…”

Section: Adverse Effects Of Pm On Respiratory Diseases Identified In mentioning

confidence: 99%

“…Air pollution inside homes consists of a complex mixture of agents penetrating from ambient outdoor air, and agents generated by indoor sources. Indoor pollutants can vary in their potential health hazard and intensity, as well as in their distribution across geographic areas, cultural backgrounds, and socioeconomic status (Breysse et al, 2010).…”

Section: Adverse Effects Of Pm On Respiratory Diseases Identified In mentioning

confidence: 99%

See 3 more Smart Citations

Particulate Air Pollutants and Respiratory Diseases

Jang¹

2012

Air Pollution - A Comprehensive Perspective

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Section: Adverse Effects Of Pm On Respiratory Diseases Identified In mentioning

confidence: 88%

Section: Adverse Effects Of Pm On Respiratory Diseases Identified In mentioning

confidence: 99%

Section: Adverse Effects Of Pm On Respiratory Diseases Identified In mentioning

confidence: 99%

Section: Adverse Effects Of Pm On Respiratory Diseases Identified In mentioning

confidence: 99%

See 2 more Smart Citations

Particulate Air Pollutants and Respiratory Diseases

Jang¹

2012

Air Pollution - A Comprehensive Perspective

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“…Automobile exhaust, emissions from power plants powered by fossil fuels, and refineries are the most common sources of outdoor NO 2 . The indoor NO 2 concentration depends on both the outdoor concentration and indoor emissions (Cyrys et al, 2000;Breysse et al, 2010), as well as air exchange rates (Sakai et al, 2004). In indoor environments, NO 2 emission is mainly due to combustion processes, such as unvented combustion appliances (e.g., gas stoves), vented appliances with defective installations, and tobacco smoke.…”

mentioning

confidence: 99%

Effect of indoor nitrogen dioxide on lung function in urban environment

Cibella

Cuttitta

Maggiore

et al. 2015

Environmental Research

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a b s t r a c tBackground: High levels of indoor NO 2 are associated with increased asthma symptoms and decreased expiratory peak flows in children. We investigated the association of exposure to domestic indoor NO 2 , objectively measured in winter and spring, with respiratory symptoms and lung function in a sample of adolescents from a southern Mediterranean area. Methods: From a large school population sample (n ¼2150) participating in an epidemiological survey in the urban area of the City of Palermo (southern Italy), a sub-sample of 303 adolescents was selected which furnished an enriched sample for cases of current asthma. All subjects were evaluated by a health questionnaire, skin prick tests and spirometry. One-week indoor NO 2 monitoring of their homes was performed by diffusive sampling during spring and again during winter. Results: We found that about 25% of subjects were exposed to indoor NO 2 levels higher than the 40 mg/m 3 World Health Organization limit, during both spring and winter. Moreover, subjects exposed to the highest indoor NO 2 concentrations had increased frequency of current asthma (p ¼0.005), wheeze episodes in the last 12 months (po0.001), chronic phlegm (p¼ 0.013), and rhinoconjunctivitis (p¼ 0.008). Finally, subjects with a personal history of wheeze ever had poorer respiratory function (FEF 25-75% , p ¼0.01) when exposed to higher indoor NO 2 concentrations. Conclusions: Home exposure to high indoor NO 2 levels frequently occurs in adolescents living in a southern Mediterranean urban area and is significantly associated with the risks for increased frequency of both respiratory symptoms and reduced lung function.

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A Randomized Trial of Air Cleaners and a Health Coach to Improve Indoor Air Quality for Inner-City Children With Asthma and Secondhand Smoke Exposure

Butz

Matsui

Breysse

et al. 2011

Arch Pediatr Adolesc Med

142

168

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Objective: To test an air cleaner and health coach intervention to reduce secondhand smoke exposure compared with air cleaners alone or no air cleaners in reducing particulate matter (PM), air nicotine, and urine cotinine concentrations and increasing symptom-free days in children with asthma residing with a smoker. Design: Randomized controlled trial, with randomization embedded in study database. Settings: The Johns Hopkins Hospital Children’s Center and homes of children. Participants: Children with asthma, residing with a smoker, randomly assigned to interventions consisting of air cleaners only (n=41), air cleaners plus a health coach (n=41), or delayed air cleaner (control) (n=44). Main Outcome Measures: Changes in PM, air nicotine, and urine cotinine concentrations and symptom-free days during the 6-month study. Results: The overall follow-up rate was high (91.3%). Changes in mean fine and coarse PM (PM2.5 and PM2.5–10) concentrations (baseline to 6 months) were significantly lower in both air cleaner groups compared with the control group (mean differences for PM2.5 concentrations: control, 3.5 μg/m3; air cleaner only, −19.9 μg/m3; and air cleaner plus health coach, −16.1 μg/m3; P=.003; and PM2.5–10 concentrations: control, 2.4 μg/m3; air cleaner only, −8.7 μg/m3; and air cleaner plus health coach, −10.6 μg/m3; P=.02). No differences were noted in air nicotine or urine cotinine concentrations. The health coach provided no additional reduction in PM concentrations. Symptom-free days were significantly increased in both air cleaner groups compared with the control group (P=.03). Conclusion: Although the use of air cleaners can result in a significant reduction in indoor PM concentrations and a significant increase in symptom-free days, it is not enough to prevent exposure to secondhand smoke.

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Indoor Air Pollution and Asthma in Children

Cited by 182 publications

References 33 publications

Particulate Air Pollutants and Respiratory Diseases

Particulate Air Pollutants and Respiratory Diseases

Effect of indoor nitrogen dioxide on lung function in urban environment

A Randomized Trial of Air Cleaners and a Health Coach to Improve Indoor Air Quality for Inner-City Children With Asthma and Secondhand Smoke Exposure

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