Prospective study of adiposity and weight change in relation to prostate cancer incidence and mortality

Abstract

The crystalline structure of the heat‐sealed part of oriented polypropylene (OPP) and cast polypropylene (CPP) films was investigated by differential scanning calorimetry, Fourier transform infrared spectroscopy, and thermal mechanical analysis (TMA). The relationship between the crystalline structure and the mechanical properties was analyzed. It was found that the high total crystallinity of both OPP and CPP gave rise to good mechanical properties and that the orientation of the crystalline structure in the OPP film also was an important factor. The optimum condition for heat sealing was the temperature at which total crystallinity was highest while still retaining the crystalline orientation of OPP. The assessment of crystalline orientation by TMA is an innovation initiated by the authors. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 99: 513–519, 2006

Preoperative weight change and risk of adverse outcome following radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database

“…3,[5][6][7][8][9] Previous studies also found an association between weight loss and decreased risk of developing high-grade PC, and an association between weight gain and BCR risk and PC mortality, 3,4,10 though in these studies, weight change was evaluated over many years. One study found perioperative weight gain is associated with increased recurrence vs men with stable weights.…”

“…[1][2][3][4] Among men with PC, obesity is linked with high-grade disease and biochemical recurrence (BCR) after radical prostatectomy (RP). 3,[5][6][7][8][9] Given obesity is a condition of excess body weight, it is unclear whether the obese state itself or the energy imbalance required to become obese is responsible for the poorer outcomes.…”

“…In a prospective study of 287 760 men, self-reported weight gain between age 18 and PC diagnosis was associated with increased PC mortality. 4 In a retrospective review of men diagnosed with PC undergoing RP, men with an average weight gain 41.5 kg per year between age 25 and diagnosis were at increased BCR risk. 3 However, the effect of weight change was not significant after controlling for body mass index (BMI).…”

Association between prostate-specific antigen and leptin, adiponectin, HbA1c or C-peptide among African-American and Caucasian men

“…12 Furthermore, clinical prostate cancer risk has been associated with the metabolic syndrome, 13,14 centralized obesity, 15 leptin levels [16][17][18] and insulin resistance. 19,20 However, several studies report no evidence of an association, [21][22][23][24][25][26][27] while others report that BMI is associated with reduced risk of prostate cancer, particularly low-grade tumors. [28][29][30] Finally, there is evidence that prostate cancer risk changes with time following a diabetes diagnosis, from an increased risk proximal to the diabetes diagnosis to a reduction in risk, 31,32 perhaps related to diabetes treatment, disease progression or changes in prostate cancer screening practices with time following a diabetes diagnosis.…”

The likelihood of having a serum PSA level of ≥2.5 or ≥4.0 ng ml−1 according to obesity in a screened Korean population

“…16,17 It has therefore been suggested that obese men experience a detection bias, minimising or even reversing the association between obesity and PCa risk (i.e., obesity becomes 'protective'), as demonstrated by several recent large prospective cohort studies. [18][19][20] However, we hypothesize that the association between obesity and advanced disease will persist if obesity is biologically linked with aggressive disease. 21 Indeed, a meta-analysis of multiple prospective Obesity-related lowered PSA on PCa screening WJ Yang 771 studies found that although obesity has a null or slightly protective effect in localized disease, it is associated with an increased incidence of advanced PCa.…”