Prospective screening for coeliac disease in patients with Graves’ hyperthyroidism using anti‐gliadin and tissue transglutaminase antibodies

Ch’ng, Chin Lye; Biswas, Mousumi; Benton, Ann; Jones, Mark T.; Kingham, J. G. C.

doi:10.1111/j.1365-2265.2005.02214.x

Cited by 73 publications

(48 citation statements)

References 29 publications

(39 reference statements)

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“…This is somewhat lower than recent (smaller) studies which reported percentages between 2.7 and 4.8 (20)(21)(22)(23). We ruled out IgA-deficiency since Em and TTG test are an IgA-class test.…”

Section: Graves'contrasting

confidence: 40%

Clustering of additional autoimmunity behaves differently in Hashimoto's patients compared with Graves' patients

Wiebolt

Achterbergh

Boer

et al. 2011

European Journal of Endocrinology

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Section: Graves'contrasting

confidence: 40%

Clustering of additional autoimmunity behaves differently in Hashimoto's patients compared with Graves' patients

Wiebolt

Achterbergh

Boer

et al. 2011

European Journal of Endocrinology

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“…Further supportive of a link between these three immune-mediated conditions is the higher prevalence of CD in both T1D and ATD (7)(8)(9)(10).…”

mentioning

confidence: 99%

Celiac Disease Increases Risk of Thyroid Disease in Patients With Type 1 Diabetes: A Nationwide Cohort Study

et al. 2015

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OBJECTIVEBoth type 1 diabetes (T1D) and celiac disease (CD) have been linked to autoimmune thyroid disease (ATD). We examined if individuals with both T1D and CD were at a higher risk of ATD than those with only T1D. RESEARCH DESIGN AND METHODSThis study was a nationwide population-based cohort study. We defined T1D as having an inpatient or a hospital-based outpatient diagnosis of T1D at age £30 years in the Swedish National Patient Register between 1964 and 2009. Data on CD were obtained through small intestinal biopsy reports showing villous atrophy (Marsh histopathology grade III) between 1969 and 2008 at any of the 28 pathology departments in Sweden. ATD included hyperthyreosis and hypothyreosis, defined according to the Swedish National Patient Register. We identified 947 individuals with T1D and biopsy-verified CD. These were matched to 4,584 control subjects with T1D but no CD diagnosis. Cox regression then estimated the risk of ATD. RESULTSAmong T1D, CD was a risk factor for later ATD. During follow-up, 90 T1D+CD patients developed ATD (expected n = 54). Adjusting for sex, age, and calendar period, this corresponded to a hazard ratio (HR) of 1.67 (95% CI 1.32-2.11; P < 0.001). This excess risk was highest in those who had CD for 10 years or more (HR 2.22 [95% CI 1.49-3.23]). Risk increases were seen in both males and females. CD was a risk factor for both hypothyreosis (HR 1.66 [95% CI 1.30-2.12]) and hyperthyreosis ). CONCLUSIONSAmong patients with T1D, CD is a risk factor for the later development of ATD.Celiac disease (CD) is an immune-mediated enteropathy that has a prevalence of 1% in Western populations (1). It occurs in genetically susceptible individuals after exposure to dietary gluten, which is a protein found in wheat, barley, and rye. Strict adherence to a gluten-free diet is the mainstay of treatment for CD, which reduces the risk of developing serious complications such as lymphoma, osteoporosis, hyposplenism, anemia, and other micronutrient deficiencies (2). CD has been linked to both type 1 diabetes (T1D) and autoimmune thyroid disease (ATD) (3,4). The development of autoimmune conditions in CD may be related to the duration of gluten exposure, although previous findings from the literature are conflicting (5,6).

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“…However, the real pathogenetic link between the immune response and the pathogenesis of CD is still foggy, despite the hundreds of reports (now repetitive) describing the reliability of the determination of transglutaminase autoimmunity in diagnosis of CD. In addition, it is emerging that antitransglutaminase antibodies are also raised in a few other autoimmune conditions, including heart failure, thyroid and articular diseases (Ch'ng et al 2005;Sane 2008). …”

Section: The Years Of Diseasementioning

confidence: 99%

An overview of the first 50 years of transglutaminase research

2008

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Prospective screening for coeliac disease in patients with Graves’ hyperthyroidism using anti‐gliadin and tissue transglutaminase antibodies

Cited by 73 publications

References 29 publications

Clustering of additional autoimmunity behaves differently in Hashimoto's patients compared with Graves' patients

Clustering of additional autoimmunity behaves differently in Hashimoto's patients compared with Graves' patients

Celiac Disease Increases Risk of Thyroid Disease in Patients With Type 1 Diabetes: A Nationwide Cohort Study

An overview of the first 50 years of transglutaminase research

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