Prospective, Randomized, Controlled Clinical Trial of a Novel Matrix Hemostatic Sealant in Children Undergoing Adenoidectomy

Mathiasen, Ronald A.; Cruz, Raul M.

doi:10.1016/j.otohns.2004.05.025

Cited by 58 publications

(51 citation statements)

References 13 publications

(26 reference statements)

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“…Binnetoglu et al [17] evaluated the use of TGHM in the case of secondary bleeding after tonsillectomy, particularly for patients with multiple sites of bleeding and/or an overcauterized tonsillar bed, confirming the effectiveness of this product as a means of achieving competent hemostasis. Jo and Mathiasen [18] and Mathiasen et al [19] prospectively assessed the use of this hemostatic matrix in children who underwent adenoidectomy and adenotonsillectomy, respectively. These authors found that the use of TGHM was associated with shorter operative times, less blood loss, and with decreased postoperative morbidity.…”

Section: Discussionmentioning

confidence: 99%

Securing Hemostasis in Pediatric Low-Grade Posterior Cerebral Fossa Tumors: The Value of Thrombin-Gelatin Hemostatic Matrix

Baro¹,

Denaro²,

D’Avella³

2018

Pediatr Neurosurg

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Purpose: We report our preliminary experience concerning the use of thrombin-gelatin hemostatic matrix to strengthen the final hemostasis after posterior fossa low-grade tumor surgery in children. To our knowledge, this is the first report regarding the use of hemostatic matrix in pediatric neurosurgery. Materials and Methods: Between 2012 and 2016, twenty-three patients underwent posterior fossa surgery for low-grade gliomas in our department. The mean age was 6.35 years; 12 patients were female and 11 male. Histology revealed pilocytic astrocytoma in 15 cases, ependymoma in 7 cases, and gangliocytoma in 1 case. At the end of the surgery, effective hemostasis was achieved using standard methods and, in order to strengthen the final hemostasis, we used a thrombin-gelatin hemostatic matrix. In all of the cases a postoperative MRI was performed within 24 after the surgery; during hospitalization the patients underwent a clinical evaluation. Moreover, blood samples were taken to evaluate inflammatory parameters, hemoglobin, and sodium, and kidney and liver tests were performed according to the standard protocol. Results: The postoperative MRI did not show any complications imputable to the matrix. Dur ing radiological and clinical follow-up none of the patients showed any delayed complications related to the matrix. Conclusions: In our practice we found thrombin-gelatin hemostatic matrix sealant to be a valid and safe tool for strengthening hemostasis in pediatric low-grade posterior fossa surgery.

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Section: Discussionmentioning

confidence: 99%

Securing Hemostasis in Pediatric Low-Grade Posterior Cerebral Fossa Tumors: The Value of Thrombin-Gelatin Hemostatic Matrix

Baro¹,

Denaro²,

D’Avella³

2018

Pediatr Neurosurg

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“…Adenoidectomy is on e of the m ost co mmonly perf ormed p rocedures in children , but b leeding f ollowing adenoidectomy may pose a s a c hallenge to a surgeon and m ay require the pl acement of a post erior n asopharyngeal pack followed by a subsequent prolonged hospitalisation (Mathiasen and Cruz, 2004). Therefore, improvements in currently used techniques and innovations th at enable a m ore ef ficient bl eeding control dur ing and f ollowing adenoid ectomy would be welcomed.…”

Section: Discussionmentioning

confidence: 99%

“…Tradition al electrical and mechanical m eans are still the m ainstay of haemorrhage control, but new h aemostatic technologies continue to emerge (de la Torre et al, 2007). Mechanical and active topical sealants and haemostatic agents are now available in different forms; these agents can be used in a variety of settings as adjuncts to the control of surgical bleeding (Spotnitz et al, 2007;Jo et al, 2007;Mathiasen and Cruz, 2004).…”

Section: Discussionmentioning

confidence: 99%

Haemostatic effect of Ankaferd Blood Stopper® seen during adenoidectomy

Yaşar¹,

Özkul²

2011

Afr. J. Trad. Compl. Alt. Med.

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In Turkey, Ankaferd Blood Stopper ® (ABS) has been approved for the management of external haemorrhages and bleedings o ccurring during den tal surgeries (Goker et al., 200 8). A nkaferd co mprises a standardized m ixture of plants, including Thymus vulgaris, Glycyrrhiza glabra, Vitis vinifera, Alpinia officinarum, and Urtica diodica. This stud y aimed to evaluate the ef ficacy of AB S tam ponade in the contro l of intra-oper ative b leeding occurring during ad enoidectomy performed in children under th e age of 12. Sixty children were randomized to receive 1 to 5 m inute-tamponade with either ABS or topical gauze spong es soaked in saline solution (SS) d uring their ad enoidectomy.. Ti me-to-haemostasis and the number of packs required wer e recorded. A visual analog scale was used by the operating surgeon to record subjective data, including the rate of bleeding f ollowing the f irst adenoid pack removal (0= none, 3=brisk). Co mpared to the child ren in the SS group (n=30), time-to-haemostasis seen in ABS patients (n=30) was significantly shorter (mean ± standard deviation, 1.93 ± 1.39 m in vs 3 .20 ± 1.50 min; p<0.0001); they required a lower number of packs (m ean, 1.93 vs. 3.20), and appeared to bleed less (53.3% vs 6.7%; p=0.0001). ABS aids in the contro l of intra-operative bleeding and reduces the number of packs required to achieve h aemostasis, so th at it can be recommended f or tamponades per formed during paediatric adenoidectomies.

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“…Adenoidectomy is a common surgical procedure conducted throughout childhood, with nearly 300,000 cases annually [1]. Various adenoidectomy techniques have been described.…”

Section: Introductionmentioning

confidence: 99%

“…Studies indicate that the average intraoperative hemorrhage during adenoidectomy is 43-54 ml. In the event that the hemorrhage exceeds 100 ml, the risk of postoperative complications increases [1].…”

Section: Introductionmentioning

confidence: 99%