Prospective Randomized Control Study on the Effect of Branched‐chain Amino Acids in Patients With Liver Resection for Hepatocellular Carcinoma

Meng, Wei; Leung, Aaron Kam-Lun; Ho, Rita; Leung, TW; Lau, Wan Yee

doi:10.1046/j.1440-1622.1999.01701.x

Cited by 62 publications

(77 citation statements)

References 8 publications

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“…In contrast, long lasting effects of BCAA supplementation were reported in patients with a metabolic or nutritional deficiency like in septic or cancer patients. In these patient groups BCAA supplementation was reported to result in positive effects on albumin status, quality of life and overall survival (Jimenez Jimenez et al, 1991;Garcia-de-Lorenzo et al, 1997;Surgery, 1997;Meng et al, 1999;Poon et al, 2004). Moreover, it has been reported that protein synthesis can only be stimulated in the presence of a high supply of balanced amounts of essential amino acids (Rooyackers and Nair, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…There are two clinical trials in cancer patients that studied oral BCAA supplementation after surgical removal of the tumour. These studies reported a shorter hospital stay, a better performance status at 3 months and an increased body mass at 1 year following surgery (Surgery, 1997;Meng et al, 1999). BCAAs have also been supplemented in the presence of the tumour: patients undergoing chemotherapy received oral BCAA supplementation up to 1 year after the start of chemotherapy, resulting in a lower overall morbidity, an improved nutritional status and a better quality of life (Poon et al, 2004).…”

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confidence: 99%

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Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

et al. 2009

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Cancer cachexia is characterised by metabolic alterations leading to loss of adipose tissue and lean body mass and directly compromises physical performance and the quality of life of cancer patients. In a murine cancer cachectic model, the effects of dietary supplementation with a specific combination of high protein, leucine and fish oil on weight loss, muscle function and physical activity were investigated. Male CD2F1 mice, 6 -7 weeks old, were divided into body weight-matched groups: (1) control, (2) tumourbearing, and (3) tumour-bearing receiving experimental diets. Tumours were induced by s.c. inoculation with murine colon adenocarcinoma (C26) cells. Food intake, body mass, tumour size and 24 h-activity were monitored. Then, 20 days after tumour/ vehicle inoculation, the animals were killed and muscle function was tested ex vivo. Tumour-bearing mice showed reduced carcass, muscle and fat mass compared with controls. EDL muscle performance and total daily activity were impaired in the tumour-bearing mice. Addition of single nutrients resulted in no or modest effects. However, supplementation of the diet with the all-in combination of high protein, leucine and fish oil significantly reduced loss of carcass, muscle and fat mass (loss in mass 45, 52 and 65% of TB-con, respectively (Po0.02)) and improved muscle performance (loss of max force reduced to 55 -64% of TB-con (Po0.05)). Moreover, total daily activity normalised after intervention with the specific nutritional combination (50% of the reduction in activity of TB-con (Po0.05)). In conclusion, a nutritional combination of high protein, leucine and fish oil reduced cachectic symptoms and improved functional performance in cancer cachectic mice. Comparison of the nutritional combination with its individual modules revealed additive effects of the single components provided.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

et al. 2009

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“…Furthermore, another randomized trial showed that oral BCAA supplementation after hepatectomy for HCC significantly reduced the 30 month recurrence of HCC (28.5% vs 55.7%, P = 0.044) [75] . Perioperative BCAA treatment in patients undergoing hepatectomy was also shown to contribute to shorter hospital stay and quicker improvement of liver function during the early postoperative period [76] and to improve postoperative quality of life by restoring and maintaining nutritional status and whole-body kinetics [77] . The effect of BCAAs on HCC recurrence after radiofrequency ablation (RFA) remains unclear.…”

Section: Bcaas For Liver Cirrhosismentioning

confidence: 99%

Branched-chain amino acids in liver diseases

Tajiri¹,

Shimizu²

2018

Transl. Gastroenterol. Hepatol.

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Branched chain amino acids (BCAAs) have been shown to affect gene expression, protein metabolism, apoptosis and regeneration of hepatocytes, and insulin resistance. They have also been shown to inhibit the proliferation of liver cancer cells in vitro , and are essential for lymphocyte proliferation and dendritic cell maturation. In patients with advanced chronic liver disease, BCAA concentrations are low, whereas the concentrations of aromatic amino acids such as phenylalanine and tyrosine are high, conditions that may be closely associated with hepatic encephalopathy and the prognosis of these patients. Based on these basic observations, patients with advanced chronic liver disease have been treated clinically with BCAA-rich medicines, with positive effects.© 2013 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Liver disease; Branched chain amino acids; Gene expression; Hepatocyte apoptosis; Hepatocyte regeneration; Immunity; Treatment Core tip: Advanced liver diseases are commonly accompanied by nutritional disturbances, which worsen the prognosis of the patients. Serum levels of branchedchain amino acids (BCAAs) are decreased in patients with liver cirrhosis, and the amino acids imbalance could affect the clinical picture of the disease and the prognosis of the patients. However, there are few comprehensive reviews on the biological activities of BCAAs. In this review, we summarize the biological activities of BCAAs, and discuss possible applications of BCAAs for the management of patients with advanced liver diseases with a list of clinical trials of BCAA administration.Tajiri K, Shimizu Y. Branched-chain amino acids in liver diseases. World

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“…One trial of parenteral nutrition 53 and five of supplements [54][55][56][57][58] included patients with hepatocellular carcinoma. The current data do not compellingly justify the routine use of parenteral nutrition, enteral nutrition, or oral nutritional supplements in these patients.…”

Section: Nutrition Management In Terminal Stage Hepatocellular Carcinomamentioning

confidence: 99%

Role of Supportive Care for Terminal Stage Hepatocellular Carcinoma

Kumar

Panda

2014

Journal of Clinical and Experimental Hepatology

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Prospective Randomized Control Study on the Effect of Branched‐chain Amino Acids in Patients With Liver Resection for Hepatocellular Carcinoma

Cited by 62 publications

References 8 publications

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

Branched-chain amino acids in liver diseases

Role of Supportive Care for Terminal Stage Hepatocellular Carcinoma

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