Role of Supportive Care for Terminal Stage Hepatocellular Carcinoma

Kumar, Manoj; Panda, Dipanjan

doi:10.1016/j.jceh.2014.03.049

Cited by 46 publications

(53 citation statements)

References 73 publications

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“…A 47-year-old portal hyperten nodular lesion smoking and c meningitis and Computed tom phase and wa characteristics confirmed a fib jst [34][35][36] [39] .…”

Section: Casementioning

confidence: 86%

Hepatocellular carcinoma treatment strategies – a case-based review

Alves

Gomes

Macedo

et al. 2015

JST

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Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide and one of the fastest growing causes of cancer-related mortality, being mostly diagnosed in patients with cirrhosis. Despite the recent efforts regarding an earlier diagnosis, the majority of patients are at advanced stages at first presentation, when the potential for institution of curative strategies is scarce. This tumor is remarkable because it occurs mostly superimposed on chronic liver diseases, which entails the need to take special attention to liver function preservation and hepatotoxicity prevention when choosing a specific therapy. Major changes had occurred in the management of HCC in the last decade. The decision-making process must be based on an accurate staging of the patient, using the Barcelona Clinic Liver Cancer (BCLC) staging system, updated knowledge of the new therapeutic options, their contraindications and the potential local or systemic complications. The authors start from 4 clinical different scenarios, in order to objectively discuss the therapeutic options available and the decision-making-process based on the staging system.

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“…A 47-year-old portal hyperten nodular lesion smoking and c meningitis and Computed tom phase and wa characteristics confirmed a fib jst [34][35][36] [39] .…”

Section: Casementioning

confidence: 86%

Hepatocellular carcinoma treatment strategies – a case-based review

Alves

Gomes

Macedo

et al. 2015

JST

View full text Add to dashboard Cite

show abstract

“…The incidence is highest in Africa and Asia where it is correlated to Hepatitis B virus (HBV) infection and to a lesser extent hepatitis C virus (HCV) infection [2,3]. Unlike Asia where hepatitis B virus infection is the predominant infection strongly associated with the subsequent development of Hepatocellular Carcinoma, hepatitis C virus infection is much more common as a predisposing factor for development of HCC in Africa and the Middle East [4].…”

Section: Introductionmentioning

confidence: 99%

“…Among HCC patients, 15-20% present with advanced HCC at initial diagnosis globally [4][5][6][7][8]. This advanced presentation is usually associated with severe physical symptoms including pain, fatigue, generalized weakness, anorexia as well as psychosocial distress [8].…”

Section: Introductionmentioning

confidence: 99%

“…Those symptoms have a negative impact on Quality of Life (QOL) and functional status of patients with advanced HCC. The definition of end stage or advanced HCC applies to patients with tumors leading to a very poor performance status (ECOG 3-4) or Child-Pugh C patients who are not amenable to transplantation [1,2,4].…”

Section: Introductionmentioning

confidence: 99%

“…As a result of this dismal survival, the [4]. The treatment for those cases should be addressed towards the management of pain and non-pain symptom, nutrition and psychosocial support.…”

Section: Introductionmentioning

confidence: 99%

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