Prospective Multinational Study of Pertussis Infection in Hospitalized Infants and Their Household Contacts

Kowalzik, Frank; Prata‐Barbosa, Arnaldo; Fernandes, Vera Regina; Carvalho, Paulo Roberto Antonacci; Ávila-Agüero, María Luisa; Goh, Daniel Yam Thiam; Goh, Anne; Miguel, Mario; Moraga, Fernando A.; Roca, Joan; Campins, Magda; Huang, Li‐Min; Quian, Jorge; riley, N; Beck, Dominique; Verstraeten, Thomas

doi:10.1097/01.inf.0000256750.07118.ee

Cited by 118 publications

(59 citation statements)

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“…Experts now recognize that household members were the primary source of pertussis infection for children (247,249,251,524,(539)(540)(541). Although the source of infection (SOI) has not been identified in more than 50% of infant cases, mothers were recognized as the main SOI for an estimated 35% of infections in the United States (247,250,540). Additional information has emerged in a number of reports from Australia and The Netherlands indicating that older children have become the most common SOI to their infant brothers and sisters (253,524,542).…”

Section: Tdap Immunization For Pregnant Womenmentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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SUMMARYPertussis is a severe respiratory infection caused byBordetella pertussis, and in 2008, pertussis was associated with an estimated 16 million cases and 195,000 deaths globally. Sizeable outbreaks of pertussis have been reported over the past 5 years, and disease reemergence has been the focus of international attention to develop a deeper understanding of pathogen virulence and genetic evolution ofB. pertussisstrains. During the past 20 years, the scientific community has recognized pertussis among adults as well as infants and children. Increased recognition that older children and adolescents are at risk for disease and may transmitB. pertussisto younger siblings has underscored the need to better understand the role of innate, humoral, and cell-mediated immunity, including the role of waning immunity. Although recognition of adult pertussis has increased in tandem with a better understanding ofB. pertussispathogenesis, pertussis in neonates and adults can manifest with atypical clinical presentations. Such disease patterns make pertussis recognition difficult and lead to delays in treatment. Ongoing research using newer tools for molecular analysis holds promise for improved understanding of pertussis epidemiology, bacterial pathogenesis, bioinformatics, and immunology. Together, these advances provide a foundation for the development of new-generation diagnostics, therapeutics, and vaccines.

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Section: Tdap Immunization For Pregnant Womenmentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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“…Numerous studies have evaluated the source of pertussis transmission to infants and typically report an unknown source of infection for $50% of infant cases. [13][14][15] When a source is identified, mothers have been the most commonly cited source of infection in the United States (32%-37%). 13,15 However, recently published data from Australia and the Netherlands suggest that siblings are playing an increasingly important role in the transmission of pertussis to young infants in these countries.…”

Section: What's Known On This Subjectmentioning

confidence: 99%

Sources of Infant Pertussis Infection in the United States

et al. 2015

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BACKGROUND: Pertussis is poorly controlled, with the highest rates of morbidity and mortality among infants. Although the source of infant pertussis is often unknown, when identified, mothers have historically been the most common reservoir of transmission. Despite high vaccination coverage, disease incidence has been increasing. We examined whether infant source of infection (SOI) has changed in the United States in light of the changing epidemiology.

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“…In addition to pertussis morbidity in infected adolescents and adults, these patients constitute a major source of transmission to infants, especially those Ͻ6 months of age, who are at highest risk for serious disease and death (3,9). Thus, pertussis immunization of adults and adolescents is recommended for both personal protection and to reduce exposure in vulnerable infants (10,11).…”

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confidence: 99%

Immunogenicity, Safety, and Antibody Persistence at 3, 5, and 10 Years Postvaccination in Adolescents Randomized to Booster Immunization with a Combined Tetanus, Diphtheria, 5-Component Acellular Pertussis, and Inactivated Poliomyelitis Vaccine Administered with a Hepatitis B Virus Vaccine Concurrently or 1 Month Apart

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Voloshen

et al. 2015

Clin Vaccine Immunol

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An understanding of the antibody persistence elicited by a combined tetanus, diphtheria, 5-component acellular pertussis, and inactivated poliovirus vaccine (Tdap-IPV) after adolescent vaccination is important to optimize booster dosing intervals. Our objectives were to compare the safety and immunogenicity of Tdap-IPV coadministered with hepatitis B vaccine (HepB) and sequential administration and evaluate humoral immunity at 3, 5, and 10 years after Tdap-IPV vaccination in adolescents. This phase II randomized, controlled, and open-label study enrolled 280 11-to 14-year-old adolescents with up to 10 years postvaccination follow-up. Group 1 (n ‫؍‬ 145) received Tdap-IPV, followed by a HepB dose 1 month later, and group 2 (n ‫؍‬ 135) received both vaccines simultaneously. No consistent increases in solicited reactions or unsolicited adverse events occurred with coadministration. All vaccinees attained seroprotective antibody levels at >0.01 IU/ml for diphtheria and tetanus, at a >1:8 dilution for poliovirus (serotypes 1, 2, and 3), and >10 mIU/ml for hepatitis B at 1 month postvaccination. Clinically relevant immunologic interactions did not occur with coadministration. For pertussis, all participants achieved seropositivity levels (at or above the lower limit of quantitation), and 72.7% to 95.8% had 4-fold increases in pertussis antibodies at 1 month postvaccination. At 10 years postvaccination, the remaining participants (62.8% of the original cohort) maintained seroprotective levels of >0.01 IU/ml for diphtheria and tetanus, a >1:8 dilution for all 3 poliovirus serotypes, and 74.1% to 98.2% maintained pertussis seropositivity levels depending on the antigen tested. There were no differences between the groups. These results support the coadministration of Tdap-IPV and HepB to adolescents and suggest that vaccination with Tdap-IPV can offer protection for 10 years after an adolescent booster vaccination. Despite widespread childhood immunization with pertussis vaccines, the recurrence of pertussis has been reported among adolescents and young adults, with periodic outbreaks in several countries, suggesting early waning of immunity (1-8). In these outbreaks, high rates of pertussis infection were observed among infants age Ͻ1 year, and the incidence in adolescents age 10 to 14 years also increased.In addition to pertussis morbidity in infected adolescents and adults, these patients constitute a major source of transmission to infants, especially those Ͻ6 months of age, who are at highest risk for serious disease and death (3, 9). Thus, pertussis immunization of adults and adolescents is recommended for both personal protection and to reduce exposure in vulnerable infants (10, 11). The current recommendations for adolescent vaccination in some European countries and most Canadian provinces include combined tetanus, diphtheria, and acellular pertussis (Tdap) and hepatitis B (HepB) vaccines (12). In Canada, the incidence of reported pertussis decreased in all age groups after the National Advisory Committee on Imm...

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Prospective Multinational Study of Pertussis Infection in Hospitalized Infants and Their Household Contacts

Cited by 118 publications

References 12 publications

Pertussis: Microbiology, Disease, Treatment, and Prevention

Pertussis: Microbiology, Disease, Treatment, and Prevention

Sources of Infant Pertussis Infection in the United States

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