Prospective Memory Deficits are Associated with Poorer Everyday Functioning in Parkinson's Disease

Abstract

Although individuals with Parkinson’s disease (PD) evidence moderate deficits in prospective memory (PM), it is not known whether PM deficits confer an increased risk of poorer everyday functioning. In the current study, 33 individuals with PD and 26 demographically similar normal controls (NC) were administered performance-based and self-report measures of PM and everyday functioning, including medication and financial management. As compared to NC, PD participants demonstrated significantly lower scores on performance-based measures of PM and financial capacity, worse performance at a trend level on performance-based medication management and endorsed significantly greater self-reported declines in PM and instrumental activities of daily living (iADLs). In the PD sample, the laboratory measure of PM significantly correlated with performance-based measures of financial capacity and medication management and a self-report measure of medication management. Self-reported PM failures significantly correlated with perceived declines in iADLs, worse medication management, and poorer health-related quality of life. Although future studies are needed to examine the incremental ecological validity of PM in PD, findings from this study extend prior research by providing preliminary evidence that PM impairment may play a significant role in a range of critical everyday functions in PD.

Neuropsychological Functioning in Veterans with Posttraumatic Stress Disorder: Associations with Performance Validity, Comorbidities, and Functional Outcomes

“…Specifically, while processing speed and executive functioning were associated with physical HRQoL but not mental HRQoL, PTSD symptoms were associated with mental HRQoL but not physical HRQoL. Prior studies in a variety of neurological and psychiatric disorders have found moderate relationships between cognitive deficits and general HRQoL (Andreou & Bozikas, 2013;Mohamed et al, 2008;Pirogovsky, Woods, Filoteo, & Gilbert, 2012), and our findings converge with research showing that better cognitive performance is associated with higher self-reported physical health and lower rates of chronic disease in the general population (e.g., Schnittker, 2005).…”

Prospective Memory Impairments in Alzheimer’s Disease and Behavioral Variant Frontotemporal Dementia: Clinical and Neural Correlates

“…The ability to remember to do something at a later point in time allows us to think and plan beyond the present moment and is essential for successful everyday adaptive functioning. Accordingly, PM dysfunction considerably limits the capacity to function independently and is associated with a decline in independent activities of daily living, difficulties with financial management, and poor medication adherence [13,14].…”

Prospective Memory Performance of Patients with Parkinson’s Disease Depends on Shifting Aptitude: Evidence from Cognitive Rehabilitation

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