Prospective evaluation of patient reported swallow function with the Functional Assessment of Cancer Therapy (FACT), MD Anderson Dysphagia Inventory (MDADI) and the Sydney Swallow Questionnaire (SSQ) in head and neck cancer patients

Peng, Luke; Hui, Xuan; Cheng, Zhi; Bowers, Michael R.; Moore, Joseph A.; Cecil, E.; Choflet, Amanda; Thompson, Alex; Muse, M.; Kiess, Ana P.; Page, B.R.; Gourin, Christine G.; Fakhry, Carole; Szczesniak, Michal; Maclean, Julia; Wu, Peter; Cook, Ian J.; McNutt, Todd; Quon, Harry

doi:10.1016/j.oraloncology.2018.05.012

Cited by 12 publications

(13 citation statements)

References 27 publications

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“…However, only a few authors have focussed on patients with the poorest prognosis–the older patients with coexisting conditions and high WHO scores [12, 13]. Treatment-induced side effects [14] [15] can be bearable as long as substantial duration of survival may be expected, but if it were possible to identify patients for whom it was short, resources could be more effectively spent on palliative, or at best supportive, care.…”

Section: Introductionmentioning

confidence: 99%

Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

Talani¹,

Mäkitie²,

Beran³

et al. 2019

PLoS ONE

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BackgroundCancers of the head and neck have a high mortality rate, and roughly 10% of the patients die within six months of diagnosis. To our knowledge little has been written about this group.We wished to identify risk factors for early death, to predict and monitor patients at risk better and, if possible, avoid unjustified major treatment.Methods and findingsThis population-based nationwide study from the Swedish Head and Neck Cancer Register (SweHNCR) included data from 2008–2015 and 9733 patients at potential risk of early death.A total of 925 (9.5%) patients died within six months. For every year older the patients became, the risk of early death increased by 2.3% (p<0.001). The relative risk of death was 3.37 times higher (237%) for patients with WHO score 1 compared with WHO score 0. A primary tumour in the hypopharynx correlated with a 24% increased risk over the oral cavity (p<0.024). Patients with stage IV disease had a 3.7 times greater risk of early death than those with stage I (p<0.001). As expected, a 12 times increased risk of early death was noted in the palliative treatment group, compared to the curative group.Limitations to this study were that the actual cause of death was not recorded in the SweHNCR, and that socioeconomic factors, alcohol consumption, smoking habits, and HPV status, were not reported in SweHNCR until 2015. However, the fact that this is a population-based nationwide study including 9733 patients compensates for some of these limitations.ConclusionsIdentification of patients at increased risk of early death shows that older patients with advanced disease, increased WHO score, primary tumour in the hypopharynx, and those given palliative treatment, are more likely than the others to die from head and neck cancer within six months of diagnosis.

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Section: Introductionmentioning

confidence: 99%

Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

Talani¹,

Mäkitie²,

Beran³

et al. 2019

PLoS ONE

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“…As patients with HNC undergo individualized treatment we recommend it important to first test PAD therapy with a temporary filler such as HA, to ensure the swallow is not further compromised, prior to applying a longer-lasting filler such as lipofilling/fat. Importantly, patients reported improvement in swallow following 38,39 PAD therapy with four of the six participants reporting reduced dysphagia symptoms and two reporting an improved oral intake scale rating (i.e., less modification required). An audit of patients at our HNC clinic reporting dysphagia symptoms identified that 14% were potentially suitable for PAD therapy.…”

Section: Discussionmentioning

confidence: 99%

“…Future studies may consider targeting this therapy for a specific tumor type and treatment regimen (3) conservative volume of HA and lipofilling, which was based on safety considerations, however may not have been large enough to display consistent efficacy outcomes, (4) not all VFSS and HRPM swallowing assessments were conducted simultaneously, which may potentially impact the VFSS aspiration ratings; (5) reliability ratings were not captured in this study. However, it should be acknowledged that reliability of HRPM analysis has been previously reported 34 and (5) despite acknowledging the impact of swallowing dysfunction on QOL, 38 specific QOL measures were not captured due to the temporary nature of the HA, instead swallow symptoms were measured pre and post‐PAD.…”

Section: Discussionmentioning

confidence: 99%

Pharyngeal tongue base augmentation for dysphagia therapy: A prospective case series in patients post head and neck cancer treatment

et al. 2022

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Background: Dysphagia post head and neck cancer (HNC) multimodality treatment is attributed to reduced pharyngeal strength. We hypothesized that pharyngeal tongue base augmentation for dysphagia (PAD therapy) would increase pharyngeal pressures during swallowing thereby improving swallow symptoms. Methods: Adults with moderate-severe dysphagia post-HNC treatment had PAD therapy using a temporary filler (hyaluronic acid [HA]), with follow-up long-lasting lipofilling. Swallowing preprocedure and postprocedure was assessed with the Sydney Swallow Questionnaire (SSQ), High-Resolution Pharyngeal Manometry (HRPM), and Videofluoroscopic Swallowing Study (VFSS). Statistical comparison utilized paired tests. Results: Six participants (all male; median age 64 years [IQR 56, 71]) underwent PAD therapy at a median of 47 [IQR 8, 95] months post-treatment. SSQ scores reduced from baseline (mean 1069 [95%CI 703, 1434]) to post-HA (mean 579 [76, 1081], p > 0.05), and post-lipofilling (491 [95%CI 913, 789], p = 0.003, n = 4). Individual participants demonstrated reduced Swallow Risk Index, Bolus Presence Time, and increased Upper Esophageal Sphincter opening, but mesopharyngeal contractile pressures were unchanged. VFSS measures of aspiration, residue, and severity were unchanged.Conclusions: Novel PAD therapy is safe and improves dysphagia symptoms.Biomechanical swallowing changes are suggestive of more efficacious bolus propulsion with conservative filler volume, but this was unable to resolve residue or aspiration measures.

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“…The Eating Assessment Tool (EAT-10) , the MD Anderson Dysphagia Inventory (MDADI) , the Functional Assessment of Cancer Therapy (FACT) , or the Sydney Swallow Questionnaire (SSQ) are based on patient-reported data. The two latter mentioned tools are similar to the MDADI with regard to the information provided 47 . Table 1 provides an overview of the acquisition tools mentioned, FACT and SSQ are not listed due to their redundancy to MDADI.…”

Section: Head and Neck Cancer Patients’ Therapy Benefit And Quality O...mentioning

confidence: 99%

Patienten-Benefit und Lebensqualität nach Roboter-assistierten Operationen im Kopf-Hals-Bereich

Hussain

2022

Laryngorhinootologie

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ZusammenfassungRobotische Systeme für den Einsatz bei Operationen im Kopf-Hals-Bereich befinden sich in unterschiedlichen Stadien der technischen Entwicklung und der klinischen Anwendung. Vorrangig kommen robotische Systeme bei transoralen Operationen im Bereich des Pharynx und Larynx zum Einsatz, erste Erkenntnisse liegen jedoch auch zu onkologischen und funktionellen Ergebnissen nach Roboter-assistierten Operationen an den Halsweichteilen, der Schilddrüse und im Bereich des Mittel- und Innenohrs vor. Das folgende Referat bietet einen Überblick über die Anwendungsbereiche der Roboter-assistierten Chirurgie im Kopf-Hals-Bereich im Hinblick auf den potenziellen Patienten-Benefit und die post-operative Lebensqualität. Der Schwerpunkt liegt dabei auf der Rolle der transoralen robotischen Chirurgie (TORS) bei der Resektion von Oropharynxkarzinomen. Für diesen Anwendungsbereich liegen umfangreiche und langfristige Erkenntnisse vor, welche funktionelle Vorteile für ausgewählte Oropharynxkarzinom-Patienten nach TORS im Vergleich zu Therapiealternativen wie der offenen Chirurgie und der primären Strahlentherapie zeigen. Da der TORS auch eine wichtige Rolle im Hinblick auf eine mögliche Therapiedeeskalation für HPV-positive Oropharynxkarzinom-Patienten zukommt, werden entsprechende laufende Studien vorgestellt. Bei der Beurteilung des Therapie-Benefits und der Lebensqualität ist insbesondere bei Tumorpatienten zu beachten, dass individuelle Patienten-Präferenzen deutlich variieren können. Beeinflussende Faktoren und Tools zur detaillierten Erfassung von Lebensqualitätsparametern werden daher zu Beginn des Referats erläutert.Während einige robotische Systeme für den Einsatz in der Ohrchirurgie und Schädelbasischirurgie in Europa entwickelt und angewandt werden, kommen TORS-Systeme derzeit vor allem in Nordamerika und Asien zum Einsatz. Dies liegt darin begründet, dass in Europa und vor allem Deutschland mit der transoralen Laser-Mikrochirurgie (TLM) seit Jahrzenten eine bewährte Technologie für die transorale Tumorresektion zur Verfügung steht. Zukünftige Studien zum Vergleich von TORS und TLM mit einer detaillierten Erfassung von Lebensqualitätsparametern könnten dazu beitragen, geeignete Anwendungsbereiche für die jeweilige Technologie zu identifizieren.

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Prospective evaluation of patient reported swallow function with the Functional Assessment of Cancer Therapy (FACT), MD Anderson Dysphagia Inventory (MDADI) and the Sydney Swallow Questionnaire (SSQ) in head and neck cancer patients

Cited by 12 publications

References 27 publications

Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

Pharyngeal tongue base augmentation for dysphagia therapy: A prospective case series in patients post head and neck cancer treatment

Patienten-Benefit und Lebensqualität nach Roboter-assistierten Operationen im Kopf-Hals-Bereich

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