Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

Talani, Charbél; Mäkitie, Antti; Beran, Martin; Holmberg, Erik; Laurell, Göran; Farnebo, Lovisa

doi:10.1371/journal.pone.0223154

Cited by 23 publications

(31 citation statements)

References 40 publications

(40 reference statements)

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“…Thus, as the perspective of strengthening primary care and the public health system, as well as reducing the number of hospitalized and severe cases, a focus on preventive work is recommended. The expansion of oral health care network can certainly have an impact in combating risk factors, which can be addressed by the dental surgeon during routine consultations, as well as increase the frequency of early diagnosis of premalignant lesions ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

“…The diagnosis of oral cancer, involving biopsy and exfoliative cytology, as well as other complementary exams, is optional for primary care dentists, and ideally, everyone should be trained to collect, order and interpret the results ( 19 ). Individuals diagnosed with oral cancer have a higher frequency of clinical stage IV ( 13 , 16 ), due to the late search for care, considering that initial injuries, in most cases, have no symptoms, being underestimated by the individual himself and by health professionals ( 15 ). Among these individuals, this study shows that men are the majority affected by stage IV cancer, as well as those who abuse of alcohol and tobacco, corroborating previous findings in the literature ( 1 , 8 , 13 ).…”

Section: Discussionmentioning

confidence: 99%

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Trend of hospitalized cases of oral cancer in Brazil and its relationship with oral health coverage in public health system between 2009 and 2017

Raymundo¹,

Freire²,

Gomes-Freire³

et al. 2021

Med Oral

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Background This study aimed to analyze the trend in the number of hospitalized cases of oral cancer in Brazil, according to the coverage of oral health services in public health system, and also investigate the influence of healthcare and clinical characteristics on the severity of oral cancer cases. Material and Methods This retrospective study considered the period between 2009 and 2017. Data from the Hospital Registry of Cancer from the National Cancer Institute were used, considering the primary locations C00 to C06. Detailed information including sex, age, alcohol and tobacco use, year of first consultation, and the clinical stage of the cases were also collected. The frequency of hospitalized cases was correlated with the coverage of Primary Care Oral Health Teams (ESB) and the number of Dental Specialty Centers (CEO). It was also estimated the chance of advanced oral cancer cases, according to healthcare and clinical characteristics. Data were analyzed using Tweedie's multiple regression and multiple binary logistic regression (α<0.05). Results There was an increasing trend in the number of hospitalized cases of oral cancer in Brazil between 2009 and 2017 (B=0.043, p<0.001, PR=1.044). The increase in ESB coverage was associated with small increase in the number of hospitalized cases of oral cancer (B=0.001, p =0.003, PR=1.001). The increase in the number of CEO was associated with decrease in the number of hospitalized cases of oral cancer (B=-0.085, p <0.001, PR =0.918). The increase of ESB (OR=0.998) and CEO (OR=0.974) contributed for reducing the number of stage IV cases, whilst the history of alcohol and tobacco use (OR=1.574) was associated with an increase in the number of stage IV cases. Conclusions Although an increasing trend was detected, the expansion of the public health system reduced the number of hospitalized cases and the frequency of advanced oral cancer cases in Brazil. Key words: Mouth neoplasms, squamous cell carcinoma, oral diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Trend of hospitalized cases of oral cancer in Brazil and its relationship with oral health coverage in public health system between 2009 and 2017

Raymundo¹,

Freire²,

Gomes-Freire³

et al. 2021

Med Oral

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“…Stage at presentation is the most important prognostic factor for squamous-cell head and neck cancers, 48 and patients with advanced tumors show the shortest survival. 49 The majority (62%) of mouth and pharyngeal cancers in Estonia in 2010–2016 presented at stage IV (69% of cases with known stage). Roughly, only a quarter of the patients in Estonia presented with early-stage disease,similar to the US, where approximately 29% of head and neck tumors were diagnosed as localized, 50 but lower than in Germany, where close to 40% of mouth and pharyngeal cancer cases with known stage were diagnosed at stages I–III.…”

Section: Discussionmentioning

confidence: 99%

Incidence and Survival for Head and Neck Cancers in Estonia, 1996–2016: A Population-Based Study

Kase¹,

Baburin²,

Kuddu³

et al. 2021

CLEP

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Background Changing patterns of alcohol and tobacco consumption and human papillomavirus (HPV) infection have affected the epidemiology of head and neck cancers. The aim of this study was to examine 20-year trends in the incidence and survival of head and neck cancers in Estonia by site, sex, morphology, and stage. Methods Data on all adult cases of invasive head and neck cancers diagnosed in Estonia in 1996–2016 were obtained from a population-based cancer registry. TNM stage was available for 2010–2016. Incidence trends were modeled with join-point regression, and five-year relative survival ratios (RSRs) were calculated. Results A total of 6,769 cases were included, 64% men. We observed declining incidence of lip and laryngeal cancer and substantial increases in the incidence of hypopharyngeal and oropharyngeal cancers. Over 60% of mouth and pharyngeal cancers were diagnosed at stage IV. Age-standardized 5-year RSR for mouth and pharyngeal cancer increased substantially over the study period, from 21% (95% CI 16%–25%) in 1996–2002 to 33% (29%–38%) in 2010–2016. The largest survival increases were seen for cancers of the oral cavity (reaching 44% in 2010–2016), tongue (41%), and larynx (63%), while modest changes were seen for the oropharynx (24%) and hypopharynx (17%). The latest 5-year RSR was 90% for thyroid cancers (99% for papillary carcinoma). Large female survival advantage was seen for most sites. Conclusion The observed trends suggest an emerging role of HPV infection in combination with traditional risk factors in the development of head and neck cancers in Estonia. Efforts targeting health behavior, HPV vaccination, and earlier diagnosis are crucial for reducing mortality from these cancers.

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“…In a recent population-based study in Sweden approximately 9% of patients were considered for palliative care at the time diagnosis of HNC [ 25 ], which is less than reported in the study by Begbie et al [ 23 ].…”

Section: Discussionmentioning

confidence: 99%

A Nordic survey of the management of palliative care in patients with head and neck cancer

Boëthius

Saarto

Laurell

et al. 2020

Eur Arch Otorhinolaryngol

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Background The five Nordic countries with a population of 27M people form a rather homogenous region in terms of health care. The management of Head and Neck Cancer (HNC) is centralized to the 21 university hospitals in these countries. Our aim was to survey the current status of organization of palliative care for patients with HNC in the Nordic countries as the field is rapidly developing. Materials and methods A structured web-based questionnaire was sent to all the Departments of Otorhinolaryngology-Head and Neck Surgery and Oncology managing HNC in the Nordic countries. Results All 21 (100%) Nordic university hospitals responded to the survey. A majority (over 90%) of the patients are discussed at diagnosis in a multidisciplinary tumor board (MDT), but the presence of a palliative care specialist is lacking in 95% of these MDT's. The patients have access to specialized palliative care units (n = 14, 67%), teams (n = 10, 48%), and consultants (n = 4, 19%) in the majority of the hospitals. Conclusion The present results show that specialized palliative care services are available at the Nordic university hospitals. A major finding was that the collaboration between head and neck surgeons, oncologists and palliative care specialists is not well structured and the palliative care pathway of patients with HNC is not systematically organized. We suggest that early integrated palliative care needs to be included as an addition to the already existing HNC care pathways in the Nordic countries.

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Early mortality after diagnosis of cancer of the head and neck – A population-based nationwide study

Cited by 23 publications

References 40 publications

Trend of hospitalized cases of oral cancer in Brazil and its relationship with oral health coverage in public health system between 2009 and 2017

Trend of hospitalized cases of oral cancer in Brazil and its relationship with oral health coverage in public health system between 2009 and 2017

Incidence and Survival for Head and Neck Cancers in Estonia, 1996–2016: A Population-Based Study

A Nordic survey of the management of palliative care in patients with head and neck cancer

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