Prospective evaluation of in vivo proton MR spectroscopy in differentiation of similar appearing intracranial cystic lesions

In Vivo Proton MR Spectroscopy Evaluation of Pyogenic Brain Abscesses: A Report of 194 Cases

“…8 Combined use of DWI/DTI along with in vivo 1 H-MR spectroscopy has been shown to improve the specificity of diagnosis in focal ring-enhancing brain lesions. [9][10][11] We present a retrospective analysis of in vivo 1 H-MR spectroscopy data for characterization of the etiology of the brain abscess based on the criteria mentioned in the literature and demonstrate the sensitivity and specificity of metabolite markers assigned to specific bacterial groups defined by the microbial culture in these patients.…”

The Role of Magnetic Resonance Spectroscopy in the Diagnosis of Ring Enhancing Lesions

“…The clinical use of proton MR spectroscopy presents several technical limitations and pitfalls [Castillo et al, 1996;Fountas et al, 2000;Preul et al, 1996;Rand et al, 1999;Shukla-Dave et al, 2001]. Proton MRS lasts approximately 15 min and requires the patient's cooperation for avoiding motion artifacts.…”

The role of proton magnetic resonance spectroscopy in the diagnosis and categorization of cerebral abscesses

“…8,17,23,26,30,38,39,42,44,52 The accuracy of this safe diagnostic tool has improved progressively since its introduction to the study of intracranial abscesses in 1994. 7,20,29 In a clinical prospective analysis conducted in 51 patients with intracranial cystic lesions that appeared similar on conventional MR imaging, Shukla-Dave et al 52 found that in vivo proton MR spectroscopy could accurate identify the underlying lesion in 92% of their cases. These results were confirmed on histopathological analysis and/or cultures obtained via an open craniotomy or stereotactic biopsy.…”

“…3). 5,7,8,10,11,14,18,19,23,25,26,30,32,36,38,39,42,46,47,51,52,58 Cerebral abscesses contain no normal neurons. 11,32 Therefore, no peaks of NAA or PCr/Cr should be detected.…”