Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia

Mendonça, Regina Maria Holanda de; Araújo, Marina Rachel; Levy, Carlos Emílio; Morari, Joseane; Silva, Rosângela A.; Yunes, José Andrés; Brandalise, Sílvia Regina

doi:10.1007/s00520-011-1190-0

Cited by 56 publications

(63 citation statements)

References 27 publications

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“…Methodology is similar to our recently published study [17]. The study cohort includes a total of 71 consecutive pediatric ALL patients, enrolled on the Brazilian Childhood Cooperative Group-protocol ALL-99 (GBTLI ALL-99) [18] and treated at the Boldrini Children's Center, from August 2005 to October 2006.…”

Section: Methodsmentioning

confidence: 99%

Oral Mucositis in Pediatric Acute Lymphoblastic Leukemia Patients: Evaluation of Microbiological and Hematological Factors

Mendonça

Araújo

Levy

et al. 2015

Pediatric Hematology and Oncology

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Section: Methodsmentioning

confidence: 99%

Oral Mucositis in Pediatric Acute Lymphoblastic Leukemia Patients: Evaluation of Microbiological and Hematological Factors

Mendonça

Araújo

Levy

et al. 2015

Pediatric Hematology and Oncology

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“…The author concluded that carrying of HSV-1 is a factor exacerbating the intensity of changes in the course of oral mucositis type, but OMI also triggers the virus replication by cytokines secreted by the damaged cells. HSV-seropositive patients more often are exposed to more severe OMI (WHO grades 3 and 4) [6]. Beek et al evaluated the presence of HSV, EBV and CMV in 49 patients treated in 2006-2009 at the University Medical Centre in Leiden, Holland, with haematological malignancies qualified for HSCT.…”

Section: Discussionmentioning

confidence: 99%

Severe herpes simplex oral mucositis in a patient with non-Hodgkin’s lymphoma after autologous stem cells transplantation – Case Report

Kostyra¹,

Mańko²,

Wojciechowicz³

et al. 2017

J Pre Clin Clin Res.

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The study presents the case of a 25-year-old patient with the diagnosis of diffuse large B cell lymphoma treated autologously with haematopoietic stem cells transplantation. During the period of aplasia after chemotherapy severe sore lips, mouth and esophagus herpes simplex mucositis developed and is successfully treated with foscarnet. The clinical course, localized causal and symptomatic treatment, along with the therapy imaging, are presented.

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“…The antineoplastic post-treatment oral affections are compounded when the individual has come from a poor oral health. This condition may be due to several causes, where the lack of information and access to health services are very relevant when surveyed in the literature [13].…”

Section: Discussionmentioning

confidence: 99%

Oral Manifestations and Salivary pH Changes in Children undergoing Antineoplastic Therapy

Hanna¹,

Botti²,

Araújo

et al. 2016

Pesqui. bras. odontopediatria clín. integr.

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Objective: To identify the oral manifestations and salivary pH before and after chemotherapy in pediatric patients. Material and Methods: The sample consisted of 46 children. It was included children from 2 to 12 years, diagnosed with Acute Lymphoblastic Leukemia (ALL) and they would be subjected to chemotherapy. The first evaluation was performed before chemotherapy and consisted of anamnesis, oral clinical examination and saliva collection to measure the pH. The second evaluation was performed among 10 to 15 days after the start of chemotherapy treatment and consisted of new saliva collection and clinical examination. Results: The results showed that the gender most affected by childhood cancer was male. The predominant age group were children aged 8-12 years. The most frequent oral manifestations were mucositis (35%), xerostomia (26%), toothache and dysphagia (22%). There was also a significant reduction in salivary pH after chemotherapy, p <0.0001, indicating that the average pre and post chemotherapy are different (Δ = 10.6) with statistical significance at the 5% level. Conclusion: Patients with ALL can present any lesion in the oral cavity during or after the start of chemotherapy and undergo changes in the amount of salivary pH. The dentist needs and know the oral manifestations and intervene in the oral health of patients with ALL, contributing and assisting in their treatment.

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Prospective evaluation of HSV, Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia

Abstract: The presence of HSV, mainly HSV-1, and Candida spp. was associated with mucositis severity in pediatric ALL. No association could be found between bacterial CFU and severity of mucositis.

Cited by 56 publications

References 27 publications

Oral Mucositis in Pediatric Acute Lymphoblastic Leukemia Patients: Evaluation of Microbiological and Hematological Factors

Oral Mucositis in Pediatric Acute Lymphoblastic Leukemia Patients: Evaluation of Microbiological and Hematological Factors

Severe herpes simplex oral mucositis in a patient with non-Hodgkin’s lymphoma after autologous stem cells transplantation – Case Report

Oral Manifestations and Salivary pH Changes in Children undergoing Antineoplastic Therapy

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