Prospective evaluation of a chamomile mouthwash for prevention of 5-FU-induced oral mucositis

Fidler, R N Pat; Loprinzi, Charles L.; O’Fallon, Judith R.; Leitch, John M.; Lee, K R N Jeraldine; Hayes, Lindsey; Novotny, Paul J.; Clemens-Schutjer, R N Danette; Bartel, Ricardo; Michalak, John C.

doi:10.1002/(sici)1097-0142(19960201)77:3<522::aid-cncr14>3.0.co;2-6

Cited by 145 publications

(102 citation statements)

References 8 publications

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“…112 Only one uncontrolled prevention study reported on encouraging results with chamomile mouthwashes, 113 whereas a placebo-controlled trial in which 164 patients undergoing 5-FU based chemotherapy were enrolled observed no difference between patients receiving chamomile mouthwashes or placebo. 114 Similarly, the efficacy of other frequently used astringent and anti-inflammatory herbal essences including sage, tormentill, and fennel, has not yet been evaluated in clinical trials.…”

Section: Chamomilementioning

confidence: 99%

Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment

Köstler

Hejna

Wenzel

et al. 2001

CA: A Cancer Journal for Clinicians

289

252

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The incidence and severity of oral mucositis is influenced by the type of antineoplastic treatment administered and by patient-related factors. Severe courses of oral mucositis are observed during simultaneous radiochemotherapy, which Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and TreatmentWolfgang J. Köstler, MD; Michael Hejna, MD; Catharina Wenzel, MD; and Christoph C. Zielinski, MD 290 CA A Cancer Journal for Clinicians ABSTRACT Chemotherapy-and radiotherapy-induced oral mucositis represents a therapeutic challenge frequently encountered in cancer patients. This side effect causes significant morbidity and may delay the treatment plan, as well as increase therapeutic expenses.The pathogenesis of this debilitating side effect can be attributed to the direct mucosal toxicity of cytotoxic agents and ionizing radiation and to indirect mucosal damage caused by a concomitant inflammatory reaction exacerbated in the presence of neutropenia, and the emergence of bacterial, mycotic, and viral infections. affects virtually all patients with head and neck cancer who receive this therapeutic modality. 8 However, up to 40% of patients treated with conventional chemotherapy and the more than 70% of patients undergoing conditioning therapy for bone marrow transplantation also experience oral treatment-related complications. 9,10The pathogenesis of oral mucositis is not fully understood, yet it is thought to involve direct and indirect mechanisms. Direct mucosal injury by radiation and chemotherapy interfere with the average 5-to 14-day turnover time of the oral epithelium 11 and induce apoptosis. Indirect stomatotoxic effects that result from the release of inflammatory mediators, loss of protective salivary constituents, and therapyinduced neutropenia have been postulated to contribute to the development of oral mucositis and also promote the emergence of bacteria, fungi, and viruses on damaged mucosa.12 Although a linear relationship among the occurrence of oral mucositis, oral and systemic granulocyte counts, and a coincidence of resolution of mucositis with neutrophil recovery, has been demonstrated, 10,[13][14][15] significant mucositis can occur in the absence of myelotoxicity. 16,17 In addition, the prophylactic or therapeutic elimination of the pathogenic mucosal flora frequently observed in patients developing oral mucositis by various antiseptic and antimicrobial agents can at most alleviate the course of oral mucositis (see Antimicrobal Agents p. 302).Based upon these considerations, newer pathophysiologic concepts have emerged characterizing oral mucositis as having an initial inflammatory/vascular phase, an epithelial phase, a (pseudomembraneous) ulcerative/bacteriological phase and a healing phase.18 During the inflammatory phase, tissue injury induces release of free radicals, modified proteins and proinflammatory cytokines including interleukin-1β, prostaglandins and tumor necrosis factor-α (TNF-α) by epithelial, endothelial, and connective tissue cells. These ...

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Section: Chamomilementioning

confidence: 99%

Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment

Köstler

Hejna

Wenzel

et al. 2001

CA: A Cancer Journal for Clinicians

289

252

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“…Fidler et al [27] admitted that there is no absolutely safe intervention for the prevention of oral mucosal lesions in patients undergoing antineoplastic chemotherapy. Various chemical substances have been tested for this purpose [10,16,20,23,24,28] and chlorhexidine has shown excellent results regarding the promotion of oral health, reducing the severity and duration of mucositis in patients with ALL submitted to chemotherapy and in a state of severe neutropenia [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Prevention of oral lesions in children with acute lymphoblastic leukemia

Pinto

Souza

Gordón-Núñez

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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Summary Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children and is responsible for severe stomatologic complications. Treatment consists of four phases of chemotherapy, the main side effect of methotrexate, the drug most used during the intensification phase, is oral mucositis. Objective: To evaluate the clinical aspects of the oral mucosa of children with ALL and to determine the effect of 0.12% chlorhexidine gluconate on the prevention of stomatologic complications in these patients. Patients and methods: Thirty-three children treated for ALL ranging in age from 2 to 15 years, without distinction of gender or race, were submitted to visual examination, digital palpation of the oral mucosa and cytologic examination of the buccal mucosa, and divided into two groups: group I consisted of 23 children using an oral solution of 0.12% chlorhexidine gluconate twice a day, and group II consisted of 10 children who did not receive this solution. All children received daily oral hygiene care guided by the dentist throughout treatment. Results: Mucositis was observed in six children of group I and eight of group II, and was characterized by erythema, edema and ulcers. Uniform cytologic findings were

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“…Antibakteriyel, antiseptik etkisi olduğu bilinen papatya suyunun methotrexate tedavisi alan hastalarda gelişen mukozitlerin tedavisinde etkili olduğu, [38] başka bir çalışmada ise, önlemede etkili olmadığı saptanmıştır. [39] Literatürde yapı-lan bir çalışmada, kanser hastalarında oral mukozitin önlenme-sinde adaçayı kekik ve nane bitkilerinin kullanıldığı görülmüş-tür. Yapılan bu çalışmada, temel ağız bakımına ek olarak adaçayı, kekik ve nane yağ altı suyu ile yapılan ağız bakımının oral mukoziti önlemede etkili olduğu görülmüştür.…”

Section: Diğer Yaklaşımlarunclassified

Evidence-Based Practices for Mucositis

Yayla¹

2017

HEAD

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ÖZ ABSTRACTMucositis is the inflammation and ulceration of the mucous membranes in the oral and/or gastrointestinal tracts. Mucositis can increase the length of hospital stays, the risk of infection, and the need for total parenteral nutrition and opioid analgesics, which can all affect a patient's quality of life negatively. The use of evidence-based guidelines developed for prevention and treatment of mucositis is extremely important in clinical areas. Nurses play a significant role in implementing and evaluating evidence-based practice guidelines for managing mucositis.

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Prospective evaluation of a chamomile mouthwash for prevention of 5-FU-induced oral mucositis

Abstract: The resultant data from this clinical trial did not support the prestudy hypothesis that chamomile could decrease 5-FU-induced stomatitis.

Cited by 145 publications

References 8 publications

Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment

Oral Mucositis Complicating Chemotherapy and/or Radiotherapy: Options for Prevention and Treatment

Prevention of oral lesions in children with acute lymphoblastic leukemia

Evidence-Based Practices for Mucositis

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