Prospective evaluation of a 21-sample needle biopsy procedure designed to improve the prostate cancer detection rate

Taille, Alexandre de la; Antiphon, Patrick; Salomon, Laurent; Cherfan, Maguy; Porcher, Raphaël; Hoznek, Andràs; Saint, F.; Vordos, Dimitri; Cicco, Antony; Yiou, R.; Zafrani, Élie Serge; Chopin, Dominique; Abbou, Claude C.

doi:10.1016/s0090-4295(03)00108-0

Cited by 175 publications

(113 citation statements)

References 23 publications

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“…Naughton et al showed significantly higher incidence of hemospermia with 12 core (89%) biopsy when compared with six core (71%) technique. In contrast, De la Taille et al 23 studied 303 patients with 21 core biopsy and reported 60% hemospermia. Reitbergen et al 25 demonstrated that hemospermia and hematuria were less frequently seen in men with prostate cancer in the biopsy specimen.…”

Section: Discussionmentioning

confidence: 95%

“…The mean duration of spontaneous resolution of hemospermia was 3.5 weeks. De la Taille et al 23 reported 12.8 days as the mean duration for resolution of hemospermia. Rodriguez et al 7 observed persistent hemospermia over a month in 10% of men after TRUS-PB.…”

Section: Discussionmentioning

confidence: 98%

“…They reported that 89% (n ¼ 71) of 12 core group and 71% (n ¼ 57) of 6 core group had hemospermia. 6 De la Taille et al 23 prospectively evaluated the cancer detecting ability of the 21 sample needle biopsy with 303 men and reported 60% incidence of hemospermia in postbiopsy period. There was no significant difference in the incidence of hemospermia between symptomatic patients having biopsy subsequent to hospital referral and patients attending screening clinics.…”

Section: Discussionmentioning

confidence: 99%

“…9,22,26,27 On the other hand, most prospective studies reported higher incidence of hemospermia when compared to retrospective studies. 6,23,24 This may well be due to recall bias and insufficient data collection in retrospective studies. In most series, the proportion of men ejaculated before the follow-up interview was not available, and this could reflect on the true incidence of this complication.…”

Section: Discussionmentioning

confidence: 99%

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Hemospermia following transrectal ultrasound-guided prostate biopsy: a prospective study

Manoharan

Ayyathurai

Nieder

et al. 2007

Prostate Cancer Prostatic Dis

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Hemospermia is known to be associated with transrectal ultrasound-guided prostate biopsy (TRUS-PB). The true incidence of hemospermia, its duration and implications are not well established. We performed a prospective observational study involving patients undergoing TRUS-PB for suspected prostate cancer at our institution. Sixty-three eligible men were included in the study. Most men (84%) undergoing TRUS-PB, who were able to ejaculate, experienced hemospermia, which was associated with some degree of anxiety. The mean duration of hemospermia was 3.5 (71.7) weeks. The number of ejaculations before the complete resolution of hemospermia was 8 (76.7). None of the clinical and pathological factors was a significant predictor of the duration of hemospermia. Patients should be adequately counseled before TRUS-PB to avoid undue anxiety and alterations in sexual activity.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Hemospermia following transrectal ultrasound-guided prostate biopsy: a prospective study

Manoharan

Ayyathurai

Nieder

et al. 2007

Prostate Cancer Prostatic Dis

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“…All patients underwent clinical evaluations, including digital rectal examinations, serum PSA, and transrectal ultrasound. All the patients had undergone a 21-core biopsy protocol as previously described for abnormal digital rectal findings or elevated PSA [19]. All the biopsies and radical prostatectomies were performed in our department and specimens were evaluated by senior uropathologists.…”

Section: Methodsmentioning

confidence: 99%

Pathological Findings and Prostate Specific Antigen Outcomes After Radical Prostatectomy in Men Eligible for Active Surveillance—Does the Risk of Misclassification Vary According to Biopsy Criteria?

et al. 2010

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Word count abstract: Word count text :2 ABSTRACT Purpose: To evaluate and compare the pathological findings and the PSA outcomes after radical prostatectomy (RP) in men eligible for AS, according to 3 different biopsy inclusion criteria. Materials and Methods:The study population included 177 men eligible for AS who fulfilled clinico-biological criteria (Gleason score ≤6, PSA<10, clinical stage T1c) and biopsy criteria as follows: (1) <3 positive cores and <3 mm of total tumour length; (2) and/or <3 positive cores with a cancer involvement <50% in any core; (3) and/or <33% of positive cores. PSA density cut-offs of 15 and 20 ng/ml/gr were also studied among these groups. Pathological findings on RP specimens and biochemical recurrence-free survival (RFS) were studied. Median follow-up was 34 months.Results: Cancers were graded Gleason 7 on RP specimens from 48.3% to 55.4% of cases. The rates of extracapsular extension (ECE) and vesicle seminal invasion (SVI) ranged from 11.2% to 17.5%, and from 1.1% to 1.8%, respectively, regardless of PSA density. The use of PSA density as AS criterion decreased for AS by 1.4-fold and by 2.3-fold the number of men eligible according to the cut-off used. The risk of unfavourable disease (defined as pT3-4 stage and/or a Gleason score≥8) remained between 15% to 19.2% when a PSA density cut-off of 15 ng/ml/gr was used. The risk of overall unfavourable disease was significantly higher in men with a cancer involvement ≥3 mm in initial biopsy compared with men who fulfilled these most stringent biopsy criteria (27.3%, vs 13.5%, respectively; p=0.023). The 3-year biochemical RFS was 91.5% and was not affected by the 3 different AS definitions. Conclusions:Even with the use of a 21-core biopsy protocol, the rate of unfavourable disease on RP specimens remains still elevated in men eligible for AS. Patients must be informed of this risk of misclassification which is about 20% in men who fulfil the less stringent biopsy criteria.

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Prostate Neoplasm

et al. 2019

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Prospective evaluation of a 21-sample needle biopsy procedure designed to improve the prostate cancer detection rate

Cited by 175 publications

References 23 publications

Hemospermia following transrectal ultrasound-guided prostate biopsy: a prospective study

Hemospermia following transrectal ultrasound-guided prostate biopsy: a prospective study

Pathological Findings and Prostate Specific Antigen Outcomes After Radical Prostatectomy in Men Eligible for Active Surveillance—Does the Risk of Misclassification Vary According to Biopsy Criteria?

Prostate Neoplasm

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