Prospective, controlled clinical trial of Ankaferd Blood Stopper in children undergoing tonsillectomy

Teker, Ayşenur Meriç; Korkut, Arzu Yasemin; Gedikli, Orhan; Kahya, Volkan

doi:10.1016/j.ijporl.2009.09.029

Cited by 76 publications

(71 citation statements)

References 20 publications

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“…[38][39][40][41][42][43][44] The first randomized controlled clinical study was reported in 49 patients with anterior epistaxis. In patients to whom ABS was applied, significant differences in effective control of anterior epistaxis were observed compared to phenylephrine.…”

Section: Discussionmentioning

confidence: 99%

“…2 Additional clinical studies about antihemorrhagic efficacy of ABS on the bleeding due to adenoidectomy, the surgical bleeding of thyroidectomy, gastrointestinal bleedings and dental bleedings were performed with similar beneficial outcomes. [38][39][40][41][42][43][44] The findings of our present experimental study represent a starting point to investigate clinical anti-hemorrhagic effects of ABS hemostat.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histopathological Alterations in the Kidney Tissue Following Topical Ankaferd Hemostat Application in a Rat Renal Injury Model

Karakoç¹,

Akar²,

Aksu³

et al. 2012

UHOD

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Ankaferd Blood Stopper (ABS) is a novel topical hemostatic agent. ABS has been approved in Turkey for clinical hemorrhages, when the conventional control of bleeding by ligature and/or conventional hemostatic measures is ineffective. ABS has many cellular effects and could modulate numerous hemostatic proteins at the tissue and blood. ABS-induced formation of the protein network with vital erythroid aggregation covers the entire physiological hemostatic process. The aim of this study was to assess histopathological alterations due to topical ABS administration at the renal tissue level. Thirty-six Wistar rats weighing 70 to 80 gm were included into the study. The rats were divided into two groups as "the ABS-applied group" (ABS−G) and "the control group" (C−G). The animals in both groups were then again divided into the three subgroups of "postoperative (Postop.) 60th minutes", "Postop. 48th hours", and "Postop. 15th day". Therefore, there were six rats in each of the subgroups at the end of the analyses. The standard renal injury sites in the rats of ABS−G were applied 2 ml. of topical ABS, whereas 2 ml. of topical saline was applied to the renal injury sites of the rats in the C−G group. We detected significant erythrocyte aggregation and the accumulation of siderophages in the kidney tissue just after 60 minutes of ABS application persisting over 15 days. Our results indicated red blood cell accumulation and siderophages following the use of ABS are compatible with the suggested 'mechanism-of-action' of ABS that ABS-induced formation of the protein network with vital erythroid aggregation covers the entire physiological hemostatic process. Further experimental search is needed to find out the molecules inside the ABS protein library leading to the ABS-induced aggregation at the renal tissue level.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histopathological Alterations in the Kidney Tissue Following Topical Ankaferd Hemostat Application in a Rat Renal Injury Model

Karakoç¹,

Akar²,

Aksu³

et al. 2012

UHOD

View full text Add to dashboard Cite

show abstract

“…Better essential hemostatic parameters were observed following administration of ABS, even in the presence of elevated arterial blood pressure. Three ABS phase III studies [4,10,12] on vascular port insertion bleeding, anterior epistaxis, and post-tonsillectomy hemorrhage have led to its approval as a hemostatic agent in Turkey. Use of ABS to control bleeding in gastrointestinal disorders [8,[24][25][26][27] and mediastinal bleeding [5,17] shed further light on its hemostatic efficacy.…”

Section: Discussionmentioning

confidence: 99%

“…ABS was shown to effectively manage external bleeding in numerous clinical settings [4][5][6][7][8][9][10][11][12][13]. ABSinduced formation of the protein network with vital erythroid aggregation encompasses the entire physiological hemostatic process.…”

Section: Introductionmentioning

confidence: 99%

Surgical and histopathological effects of topical ankaferd hemostat on major arterial vessel injury in relation to the enhanced intra-arterial blood pressure

Uluş¹,

Turan²,

Özyalçın³

et al. 2011

Turk J Hematol

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Objective: The aim of this study was to assess the surgical and histopathological hemostatic effects of topical Ankaferd blood stopper (ABS) on major arterial vessel injury related to elevated intra-arterial blood pressure in an experimental rabbit model. Materials and Methods: The study included 14 New Zealand rabbits. ABS was used to treat femoral artery puncture on 1 side in each animal and the other untreated side served as the control. Likewise, for abdominal aortic puncture, only 50% of the aortic injuries received topical liquid ABS and the others did not (control). The experiment was performed under conditions of normal arterial blood pressure and was repeated with a 50% increase in blood pressure. Histopathological analysis was performed in all of the studied animals. Results: Mean bleeding time in the control femoral arteries was 105.0±18.3 s, versus 51.4±9.8 s (p<0.05) in those treated with ABS. Mean blood loss from the punctured control femoral arteries was 5.0±1.5 mg and 1.6±0.4 mg from those treated with ABS (p<0.05). Histopathological examination of the damaged arterial structures showed that ABS induced red blood cell aggregates. Conclusion: ABS administered to experimental major arterial vessel injury reduced both bleeding time and blood loss under conditions of normal and elevated intra-arterial blood pressure. ABS-induced erythroid aggregation was prominent at the vascular tissue level. These findings will inform the design of future experimental and clinical studies on the anti-bleeding and vascular repairing effects of the novel hemostatic agent ABS. (Turk J Hematol 2011; 28: 206-12)

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“…[8] soliter rektal ülserin başarılı kanama kontrolü için topikal ABS kullanmışlardır. KBB cerrahisinde epistaksis [9] ve tonsillektomide [10] başarılı sonuçlar alınmıştır.…”

Section: Renkli şEkiller Derginin Online Sayısında Görülebilir (Wwwkunclassified

Effectiveness of Ankaferd Blood Stopper on salivary gland bleeding

Evren¹,

Çınar²,

Sarıkaya³

et al. 2012

J Kartal TR

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4 ÖzetAmaç: Bu çalışmanın amacı Ankaferd "Blood Stopper"in (ABS) tükrük bezi dokusu üzerinde kanama durdurucu etkisini incelemektir. Gereç ve Yöntem:Çalışmada 15 erişkin Wistar Albino cinsi sıçan kullanıldı. Uygun diseksiyon işlemi sonrasında sağ submandibuler glandları tam kat kesilip 0.2 cc ABS damlatıl-dı. Sol glanda da aynı kesi işlemi sonrasında salin emdirilmiş tampon ile baskı yapıldı. İki tarafın kanama süreleri ölçüldü. Bulgular: Kanama zamanı ABS uygulanan tarafta 21.9±8.9 saniye, salin emdirilmiş tampon ile baskı yapılan tarafta 89.8±33.9 saniye olarak bulundu. ABS uygulanan tarafta kanama zamanı anlamlı olarak kısa bulundu. Sonuç:Yeni bir hemostatik ajan olarak ABS'nin tükrük bezlerinde kanamayı kontrol etmek için potansiyel bir yararı olabilir. Doku üzerinde histopatolojik etkilerini incelemek, olası toksik etkilerini belirlemek için daha çok ileriye dönük kontrollü çalışmalara ihtiyaç vardır.

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Prospective, controlled clinical trial of Ankaferd Blood Stopper in children undergoing tonsillectomy

Cited by 76 publications

References 20 publications

Histopathological Alterations in the Kidney Tissue Following Topical Ankaferd Hemostat Application in a Rat Renal Injury Model

Histopathological Alterations in the Kidney Tissue Following Topical Ankaferd Hemostat Application in a Rat Renal Injury Model

Surgical and histopathological effects of topical ankaferd hemostat on major arterial vessel injury in relation to the enhanced intra-arterial blood pressure

Effectiveness of Ankaferd Blood Stopper on salivary gland bleeding

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