Prospective Comparison of Standard Triple Assessment and Dynamic Magnetic Resonance Imaging of the Breast for the Evaluation of Symptomatic Breast Lesions

Drew, Philip; Turnbull, Lindsay W.; Chatterjee, Sumohan; Read, John; Carleton, P.J.; Fox, John; Monson, J. R. T.; Kerin, Michael J.

doi:10.1097/00000658-199911000-00010

Cited by 33 publications

(18 citation statements)

References 28 publications

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“…The specificity for the diagnosis of benign disease was as follows: clinical examination 83.1%, ultrasound 88.9%, mammography 86.4%, fine-needle aspiration cytology 97%, triple assessment 59.1% and MRI 90.9%. We concluded that DCE-MRI of the breast is as sensitive and more specific than the combined traditional triple assessment for the diagnosis of malignant breast lesions (Drew et al, 1999b). Similar findings have been reported in several other studies (Table 1).…”

Section: Symptomatic Diseasesupporting

confidence: 90%

Current applications and future direction of MR mammography

2003

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Compared with triple assessment for symptomatic and occult breast disease, magnetic resonance mammography (MRM) offers higher sensitivity for the detection of multifocal cancer, which is important in selecting patients appropriately for breast-conserving surgery. It is an ideal tool for the screening of patients with a high risk of breast cancer or where there is axillary disease or nipple discharge and conventional imaging has not revealed the primary focus. Techniques are now available to biopsy lesions only apparent on MRM. MRM can differentiate scar tissue from tumour; therefore, it is useful in patients in which there is possible recurrent disease. Clinical and X-ray mammographic assessment of response to neoadjuvant chemotherapy may be unreliable because of replacement of the tumour with scar tissue. MRM can identify responders and nonresponders with more accuracy. It is the modality of choice for the assessment of breast implants for rupture with accuracy higher than X-ray mammography and ultrasound. Advances in both spatial and temporal resolutions, the imaging sequences employed, pharmacokinetic modelling of contrast uptake, the use of dedicated and now phased-array breast coils, and gadolinium-based contrast agents have all played their part in the advancement of this imaging technique. Despite the limitations of patient compliance, scan-time and cost, this review describes how MRM has become a valuable tool in breast disease, especially in cases of diagnostic uncertainty. However, MRM must make the transition from research institutions into routine clinical practice.

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Section: Symptomatic Diseasesupporting

confidence: 90%

Current applications and future direction of MR mammography

2003

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“…Imaging and pathological investigations have appreciable false negative results. When used together 95% of symptomatic breast malignancies will be diagnosed 25 …”

Section: Systematic Review Of the Literaturementioning

confidence: 99%

Metaplastic breast carcinoma: A case report and systematic review of the literature

Toumi¹,

Bullen²,

Tang

et al. 2011

Pathology International

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A 78-year-old retired woman was diagnosed with metaplastic breast carcinoma (MBC), a rare tumor, in our hospital. We reviewed 15 articles with a total of 1328 patients to determine the epidemiology, clinical features, biomarkers, histology, management and outcome of patients with this tumor. The mean age at presentation is 58.5 years (range 32-83). Eighty-one percent of patients presented either with a breast mass or abnormal mammographic finding. Twenty-three percent of patients had a family history of breast cancer. Estrogen receptors were only found in 12%, progesterone receptors in 10% and HER2 in 6% of patients. The main method of treatment was mastectomy (66.9%) in combination with chemotherapy (57%) and radiotherapy (47%). Five-year disease-free survival ranged between 40% and 84% and 5-year overall survival ranged between 64 and 83%. We have further reviewed the nature of this disease in the light of advancement in genetics, such as microarray gene expression profiling. The relationship of MBC with triple-negative tumor and basal-like tumor is discussed. It is hoped that advances in genetics and biomarkers will bring forward the era of personalized medicine in the treatment of breast carcinoma.

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“…MRI provides a morphologic as well as physiologic approach to evaluating the breast. The sensitivity and specificity of MRI in detecting breast cancer ranges from 88–99% to 37–83%, respectively (3–7). While MRI has been lauded for its high sensitivity it has also been critiqued for its widely variable specificity.…”

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confidence: 99%

Breast-Specific Gamma Imaging with^99mTc-Sestamibi and Magnetic Resonance Imaging in the Diagnosis of Breast Cancer?A Comparative Study

Brem¹,

Petrovitch²,

Rapelyea³

et al. 2007

Breast Journal

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The purpose of this study was to compare the sensitivity and specificity of breast-specific gamma imaging (BSGI) using a high-resolution breast-specific gamma camera and magnetic resonance imaging (MRI) in patients with indeterminate breast findings. Twenty-three women with an indeterminate breast finding that required BSGI and MRI as deemed necessary by the interpreting radiologist or referring physician were included. MRI was performed on a GE 1.5T scanner and BSGI was performed on a Dilon high-resolution breast-specific gamma camera. All imaging findings were correlated with pathologic diagnosis. Thirty-three indeterminate lesions were evaluated in the study. There were a total of nine pathologically confirmed cancers. There was no statistically significant difference in sensitivity of cancer detection between BSGI and MRI. BSGI demonstrated a greater specificity than MRI, 71% and 25%, respectively. BSGI has equal sensitivity and greater specificity than MRI for the detection of breast cancer.

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Prospective Comparison of Standard Triple Assessment and Dynamic Magnetic Resonance Imaging of the Breast for the Evaluation of Symptomatic Breast Lesions

Abstract: ObjectiveTo compare the sensitivity and specificity of the traditional triple assessment of symptomatic breast lesions with contrast-enhanced dynamic magnetic resonance imaging.

Cited by 33 publications

References 28 publications

Current applications and future direction of MR mammography

Current applications and future direction of MR mammography

Metaplastic breast carcinoma: A case report and systematic review of the literature

Breast-Specific Gamma Imaging with^99mTc-Sestamibi and Magnetic Resonance Imaging in the Diagnosis of Breast Cancer?A Comparative Study

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Prospective Comparison of Standard Triple Assessment and Dynamic Magnetic Resonance Imaging of the Breast for the Evaluation of Symptomatic Breast Lesions

Abstract: ObjectiveTo compare the sensitivity and specificity of the traditional triple assessment of symptomatic breast lesions with contrast-enhanced dynamic magnetic resonance imaging.

Cited by 33 publications

References 28 publications

Current applications and future direction of MR mammography

Current applications and future direction of MR mammography

Metaplastic breast carcinoma: A case report and systematic review of the literature

Breast-Specific Gamma Imaging with99mTc-Sestamibi and Magnetic Resonance Imaging in the Diagnosis of Breast Cancer?A Comparative Study

Contact Info

Product

Resources

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Breast-Specific Gamma Imaging with^99mTc-Sestamibi and Magnetic Resonance Imaging in the Diagnosis of Breast Cancer?A Comparative Study