Prospective comparison of methicillin-susceptible and methicillin-resistant community-associated Staphylococcus aureus infections in hospitalized patients

Predominance of Methicillin-Resistant Staphylococcus aureus among Pathogens Causing Skin and Soft Tissue Infections in a Large Urban Jail: Risk Factors and Recurrence Rates

“…We found few demographic or clinical risk factors to distinguish MRSA from MSSA SSTIs, similar to what was found in other clinical settings (11,14,18,20). An exception was the use of a ␤-lactam antibiotic in the 12 months prior to index culture, which was more common among MRSA-than MSSA-positive patients in this study.…”

“…An exception was the use of a ␤-lactam antibiotic in the 12 months prior to index culture, which was more common among MRSA-than MSSA-positive patients in this study. Similarly, at an academic medical center in Dallas, the use of any antibiotic in the 6 months prior to an S. aureus SSTI drainage culture was more common among those with a MRSA SSTI (20). The explanation for this is unclear.…”

“…Studies at large medical centers have demonstrated that African-American race, young age, recent antibiotic use, homelessness, and exposure to places of incarceration were more commonly associated with CA-MRSA than with CA-MSSA infections (9,11,14,18,20). In contrast, the risk factors for a MRSA SSTI compared with a MSSA SSTI among detainee patients are not defined; they may include poor hygiene, African-American race, younger age, fewer years of education, longer duration of jail stay, outdoor work, and sharing of personal items (3,4,22).…”

Defects in Innate Immunity Predispose C57BL/6J-Leprdb/LeprdbMice to Infection byStaphylococcus aureus

“…The emergence of S. aureus strains resistant to multiple antibiotics has made treatment of staphylococcal infections especially problematic. Methicillin-resistant S. aureus strains have become increasingly prevalent among both nosocomial and communityacquired infections within the United States (22,36,43). The prevalence of methicillin-resistant S. aureus is higher among diabetic patients than in the general population (11,44,45).…”

Prospective Randomized Trial of Empiric Therapy with Trimethoprim-Sulfamethoxazole or Doxycycline for Outpatient Skin and Soft Tissue Infections in an Area of High Prevalence of Methicillin-Resistant Staphylococcus aureus

“…Skin and soft tissue infections (SSTI) caused by methicillinresistant Staphylococcus aureus (MRSA) acquired in the community have rapidly increased in prevalence over the past decade (6,7,9,11). With this shift in the epidemiology of SSTI, empirical therapy for SSTI with ␤-lactams is often no longer thought to be acceptable in those clinical situations where antibiotic therapy is deemed to be necessary.…”