Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia

Vellinga, Remco; Hannivoort, Laura N.; Introna, Michele; Touw, Daan; Absalom, Anthony; Eleveld, Douglas J.; Struys, Michel

doi:10.1016/j.bja.2020.10.027

Cited by 41 publications

(43 citation statements)

References 22 publications

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“…The reasons for this may or may not be related to better specification of the front-end kinetics or of early re-distribution. In any event, this finding is consistent with the findings of a recent prospective validation study of the Eleveld model, which confirmed its accuracy at predicting BIS values 13. A recent case report in SAJAA has also highlighted the accuracy of the new Eleveld model during TIVA in an infant requiring spinal cord neuromonitoring 14.…”

supporting

confidence: 87%

Stability of BIS with Schnider or modified Marsh effect-site targeted infusions : as you like it, or much ado about nothing?

Coetzee

Absalom

2021

Southern African Journal of Anaesthesia and Analgesia

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supporting

confidence: 87%

Stability of BIS with Schnider or modified Marsh effect-site targeted infusions : as you like it, or much ado about nothing?

Coetzee

Absalom

2021

Southern African Journal of Anaesthesia and Analgesia

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“…Propofol is a short-acting intravenous anesthetic of alkyl phenols, which is widely used in clinical practice [ 4 ]. It plays a sedative and hypnotic role by activating the GABA receptor-chloride ion complex [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Propofol Suppresses Cell Progression by Inhibiting CCL18 Expression in Hepatoblastoma

Zhang

Lin

et al. 2021

Journal of Oncology

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Background. Propofol is an anesthetic commonly used clinically and has been found to have antitumor activity in various cancers. The purpose of this study was to investigate the role of propofol in hepatoblastoma (HB). Methods. CCK-8 and transwell were used to measure cell proliferation, migration, and invasion in HB cells. Cell apoptosis rate was measured by FCM. The expression of CCL18 in HB tissues and cells was detected by RT-qPCR. Western blotting was used to explore the protein expression of CCK18- and PI3K/AKT-related proteins. Results. The expression of CCL18 in HB tissues and cells was overexpressed compared with control groups. CCL18 knockdown was found to notably block cell proliferation and progression, while enhancing cell apoptosis in HuH-6 and HepT1 cells. Furthermore, propofol suppressed the proliferation of HB cells in a dose-dependent manner. According to the results, we chose 5 μg/mL of propofol-treated cells for 48 hours as the subsequent experimental conditions. We found that propofol (5 μg/mL, 48 h) significantly blocked cell migration and invasion, but induced cell apoptosis in HuH-6 and HepT1 cells. In addition, CCK18 overexpression facilitated cell progression in HB cells, while propofol dramatically suppressed the effect of CCK18. Besides that, propofol suppressed the PI3K/AKT pathway. Conclusion. Propofol suppressed the development of HB cells by inhibiting CCK18 expression and the PI3K/AKT pathway. Therefore, we infer that propofol plays a role in the treatment of HB.

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“…Considering the idiosyncratic and variable intrapatient pharmacodynamics of propofol, we believe that, although certainly not impossible, it is highly unlikely that this dose was rigidly applied from the beginning to the end of his induced coma. 3 Often, such doses are adjusted to the patient’s hemodynamics and Richmond Agitation Scale Score and/or electroencephalographic parameters. Moreover, we would like to remind the readers that the risk of propofol-induced malignant ventricular arrhythmias even in patients with Brugada syndrome has not been demonstrated.…”

mentioning

confidence: 99%

ST-Segment Elevation, Brugada Syndrome, and Propofol?

Flamée¹,

Carvalho²,

Forget³

2022

JACC: Case Reports

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Prospective clinical validation of the Eleveld propofol pharmacokinetic-pharmacodynamic model in general anaesthesia

Cited by 41 publications

References 22 publications

Stability of BIS with Schnider or modified Marsh effect-site targeted infusions : as you like it, or much ado about nothing?

Stability of BIS with Schnider or modified Marsh effect-site targeted infusions : as you like it, or much ado about nothing?

Propofol Suppresses Cell Progression by Inhibiting CCL18 Expression in Hepatoblastoma

ST-Segment Elevation, Brugada Syndrome, and Propofol?

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