Prospective association of vitamin D with frailty status and all-cause mortality in older adults: Results from the KORA-Age Study

Vogt, Susanne; Decke, Siona; Gala, Tonia de las Heras; Linkohr, Birgit; Köenig, Wolfgang; Ladwig, Karl‐Heinz; Peters, Annette; Thorand, Barbara

doi:10.1016/j.ypmed.2015.01.010

Cited by 48 publications

(47 citation statements)

References 37 publications

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“…Four studies had a cross-sectional design [13–15, 28], two were prospective studies [18, 20], and two studies reported both cross-sectional and prospective evaluations [16, 17]. All four studies were prospective cohort studies in a total of 8209 participants who were free of frailty at baseline.…”

Section: Resultsmentioning

confidence: 99%

“…A total of six cross-sectional studies provided data on 20,949 participants, including 1802 cases of frailty. Five studies were conducted in Europe [15–18, 28], and the other three studies were conducted in the United States [13, 14, 28]. The mean age of the participants ranged from 62.2 to 79.2 years.…”

Section: Resultsmentioning

confidence: 99%

“…The mean age of the participants ranged from 62.2 to 79.2 years. Two studies [13, 28] included males only, two studies [14, 20] included females only, and four studies [16–18, 28] included both males and females. Most of the studies [13–15, 18, 20, 28] defined cases of frailty using frailty phenotypes, and the two studies by Puts et al [16] and Schöttker et al [17] used nine frailty indicators and the frailty index, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies [13, 28] included males only, two studies [14, 20] included females only, and four studies [16–18, 28] included both males and females. Most of the studies [13–15, 18, 20, 28] defined cases of frailty using frailty phenotypes, and the two studies by Puts et al [16] and Schöttker et al [17] used nine frailty indicators and the frailty index, respectively. Two studies [13, 14] used liquid chromatography tandem-mass spectrometry (LC-MS/MS), two studies [16, 18] used competitive binding protein assays, three studies [15, 17, 28] used immunoassays and one study [20] used radioreceptor assays.…”

Section: Resultsmentioning

confidence: 99%

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Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis

Lee

Kim

2018

BMC Geriatr

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BackgroundVitamin D deficiency and frailty are common with aging. Previous studies examining vitamin D status and frailty have produced mixed results, and in particular, the shape of the association has not been well established. We examined the association between 25-hydroxyvitamin D (25OHD) serum levels and frailty by performing a systematic review and dose-response meta-analysis.MethodsWe searched the PubMed, EMBASE and Cochrane Library databases of Elsevier through February 2017. Cross-sectional and cohort studies that reported adjusted risk ratios with 95% confidence intervals (CI) for frailty with ≥3 categories of 25OHD serum levels were selected. Data extraction was performed independently by two authors. The reported risk estimates for 25OHD categories were recalculated, employing a comprehensive trend estimation from summarized dose-response data.ResultsThe pooled risk estimate of frailty syndrome per 25 nmol/L increment in serum 25OHD concentration was 0.88 (95% CI = 0.82–0.95, I2 = 86.8%) in the 6 cross-sectional studies and 0.89 (95% CI = 0.85–0.94, I2 = 0.0%) in the 4 prospective cohort studies. Based on the Akaike information criteria (AIC), a linear model was selected (AIC for the nonlinear model: − 5.4, AIC for the linear model: − 6.8 in the prospective cohort studies; AIC for the linear model: − 13.6, AIC for the nonlinear model: − 1.77 in the cross-sectional studies).ConclusionsThis dose-response meta-analysis indicates that serum 25OHD levels are significantly and directly associated with the risk of frailty. Further studies should address the underlying mechanisms to explain this relationship and to determine whether vitamin D supplementation is effective for preventing frailty syndrome.Electronic supplementary materialThe online version of this article (10.1186/s12877-018-0904-2) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis

Lee

Kim

2018

BMC Geriatr

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“…Recent studies document the joined effect of low 25(OH)D concentrations and frailty on all-cause mortality in older individuals, as shown in the KORA-Age study [59], or non-institutionalized US adults aged ≥60 years [60].…”

Section: Data From Observational Studies and Meta-analysesmentioning

confidence: 94%

Sarcopenia in post-menopausal women: Is there any role for vitamin D?

et al. 2015

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Associations of fat‐soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative

Kochlik

Stuetz

Pérès

et al. 2019

J cachexia sarcopenia muscle

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BackgroundA poor fat‐soluble micronutrient (FMN) and a high oxidative stress status are associated with frailty. Our aim was to determine the cross‐sectional association of FMNs and oxidative stress biomarkers [protein carbonyls (PrCarb) and 3‐nitrotyrosine] with the frailty status in participants older than 65 years.MethodsPlasma levels of vitamins A (retinol), D3, E (α‐tocopherol and γ‐tocopherol) and carotenoids (α‐carotene and β‐carotene, lycopene, lutein/zeaxanthin, and β‐cryptoxanthin), PrCarb, and 3‐nitrotyrosine were measured in 1450 individuals of the FRAILOMIC initiative. Participants were classified into robust, pre‐frail, and frail using Fried's frailty criteria. Associations between biomarkers and frailty status were assessed by general linear and logistic regression models, both adjusted for cohort, season of blood sampling, gender, age, height, weight, and smoking.ResultsRobust participants had significantly higher vitamin D3 and lutein/zeaxanthin concentrations than pre‐frail and frail subjects; had significantly higher γ‐tocopherol, α‐carotene, β‐carotene, lycopene, and β‐cryptoxanthin concentrations than frail subjects, and had significantly lower PrCarb concentrations than frail participants in multivariate linear models. Frail subjects were more likely to be in the lowest than in the highest tertile for vitamin D3 (adjusted odds ratio: 2.15; 95% confidence interval: 1.42–3.26), α‐tocopherol (2.12; 1.39–3.24), α‐carotene (1.69; 1.00–2.88), β‐carotene (1.84; 1.13–2.99), lycopene (1.94; 1.24–3.05), lutein/zeaxanthin (3.60; 2.34–5.53), and β‐cryptoxanthin (3.02; 1.95–4.69) and were more likely to be in the highest than in the lowest tertile for PrCarb (2.86; 1.82–4.49) than robust subjects in multivariate regression models.ConclusionsOur study indicates that both low FMN and high PrCarb concentrations are associated with pre‐frailty and frailty.

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Prospective association of vitamin D with frailty status and all-cause mortality in older adults: Results from the KORA-Age Study

Cited by 48 publications

References 37 publications

Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis

Low 25-hydroxyvitamin D levels and the risk of frailty syndrome: a systematic review and dose-response meta-analysis

Sarcopenia in post-menopausal women: Is there any role for vitamin D?

Associations of fat‐soluble micronutrients and redox biomarkers with frailty status in the FRAILOMIC initiative

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