Prospective association of metal levels with gestational diabetes mellitus and glucose: A retrospective cohort study from South China

Zhou, Zixing; Chen, Gengdong; Li, Pengsheng; Rao, Jiaming; Wang, Limin; Yu, Dandan; Lin, Dongxin; Fan, Dazhi; Ye, Shaoxin; Wu, Shuzhen; Gou, Xiaoyan; Wang, Haiyan; Guo, Xiaoling; Lei, Lin; Suo, Dongmei; Liu, Zheng­ping

doi:10.1016/j.ecoenv.2020.111854

Cited by 22 publications

(28 citation statements)

References 31 publications

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“…In our previous study (25), we found significant associations between Mn, Cu, Pb, Zn, and Mg and OGTT0. Thus, we aimed to further explore the mediating effect of OGTT0 on metals and birth outcomes.…”

Section: Discussionmentioning

confidence: 58%

“…In addition, serum Mg levels have been negatively associated with fasting insulin, and higher copper concentrations could increase the risk of glucose dysregulation during pregnancy ( 23 , 24 ). Our previous study ( 25 ) also found that metals including Mn, Cu, Pb, Zn, and Mg in early pregnancy were prospectively related to later FPG in pregnant women. Moreover, high FPG levels have been linked to macrosomia and large-for-gestational-age infants ( 26 ).…”

Section: Introductionmentioning

confidence: 71%

“…Meanwhile, our previous study found that early maternal serum Mn could increase FPG at 24-28 weeks (25).…”

Section: Discussionmentioning

confidence: 93%

“…One population-based study has shown a positive relationship of urinary Mn with hyperglycemia risk in Chinese coke oven workers ( 38 ). Meanwhile, our previous study found that early maternal serum Mn could increase FPG at 24–28 weeks ( 25 ).…”

Section: Discussionmentioning

confidence: 96%

“…Metal detection was performed according to the methods described in our previous article ( 25 ). Maternal serum metal concentration was assessed only once before 24 weeks of pregnancy in our hospital.…”

Section: Methodsmentioning

confidence: 99%

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Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study

Zhou

Chen

et al. 2021

Front. Endocrinol.

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ObjectivePreviously, we found that the presence of maternal serum metals before the 24th week of gestation prospectively increased fasting plasma glucose (FPG) at 24–28 weeks. We further explored the prospective association between levels of metals and neonatal outcomes and assessed the mediating effects of FPG on these relationships.MethodsA total of 7,644 pregnant women were included in a retrospective cohort study, and the relationships between metals [manganese (Mn), copper (Cu), lead (Pb), zinc (Zn), and magnesium (Mg)] and birth outcomes were explored. Quantile and linear regressions were performed to detect the shifts and associations between metals and neonatal size distribution focused on the 10th, 50th, and 90th percentiles. Mediation analysis was performed to assess the mediating effect of FPG on metals and birth outcomes.ResultsAfter adjustment, a 50% increase in Mn and Zn levels was related to a 0.136-cm (95% CI: 0.067–0.205) and 0.120-cm (95% CI: 0.046–0.193) increase in head circumference, respectively. Based on head circumference distribution, the magnitude of the association with Mn was smaller at the upper tail, while the magnitude of correlation with Zn was greater at the upper tail. A 50% increase in Mn and Zn levels was related to a 0.135-cm (95% CI: 0.058–0.212) and 0.095-cm (95% CI: 0.013–0.178) increase in chest circumference, respectively. The magnitude of the association with Mn increased with increasing chest circumference, while the magnitude of correlation with Zn decreased with increasing chest circumference. FPG explained 10.00% and 17.65% of the associations of Mn with head and chest circumference. A positive indirect effect of Zn associated with head circumference (0.004, 95% CI: 0.002–0.006) and chest circumference (0.005, 95% CI: 0.003–0.008) through FPG was also observed, and the estimated proportion of the mediating effect was 13.79% and 26.32%, respectively.ConclusionMaternal serum Mn and Zn levels before the 24th week of gestation may prospectively increase the circumference of the neonatal head and chest. FPG at 24–28 weeks had positive mediating effects on these relationships. Further research is needed to identify a balance between maternal blood glucose and birth size.

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 71%

“…Meanwhile, our previous study found that early maternal serum Mn could increase FPG at 24-28 weeks (25).…”

Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study

Zhou

Chen

et al. 2021

Front. Endocrinol.

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Magnesium Status, Genetic Variants of Magnesium‐Related Ion Channel Transient Receptor Potential Membrane Melastatin 6 (TRPM6) and the Risk of Gestational Diabetes Mellitus in Chinese Pregnant Women: A Nested Case–Control Study

Huang,

Ge,

et al. 2023

Molecular Nutrition Food Res

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ScopeMagnesium plays an important role in regulating glucose metabolism. The study attempts to explore association between magnesium status and single nucleotide polymorphisms (SNPs) of gene involved in magnesium absorption‐transient receptor potential membrane melastatin 6 (TRPM6) and gestational diabetes mellitus (GDM) riskMethods and resultsA nested case–control study including 170 GDM cases and matched 340 controls is conducted based on Tongji Birth Cohort. Dietary, serum, and urine magnesium are evaluated before the diagnosis of GDM. Compared to the lowest tertile, women in the highest tertile of serum magnesium are at a lower risk of GDM (adjusted odds ratio [aOR] 0.42, 95% confidence intervals [CI] 0.21–0.84). Serum magnesium is inversely associated with insulin and homeostatic model assessment of insulin resistance (β = −0.05, p = 0.002; β = −0.04, p = 0.001, respectively). The aOR for GDM in carriers of the CT or CC genotypes of TRPM6 rs2274924 compared with carriers of the TT genotype is 2.76 (95% CI 1.78–4.26). Dietary magnesium is positively associated with serum magnesium (β = 0.02, p = 0.004), but not with GDM risk.ConclusionSerum magnesium and the TRPM6 rs2274924 polymorphism are associated with the risk of GDM.

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Copper and Diabetes: Current Research and Prospect

Chang,

2023

Molecular Nutrition Food Res

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Copper is an essential trace metal for normal cellular functions; a lack of copper is reported to impair the function of important copper‐binding enzymes, while excess copper could lead to cell death. Numerous studies have shown an association between dietary copper consumption or plasma copper levels and the incidence of diabetes/diabetes complications. And experimental studies have revealed multiple signaling pathways that are triggered by copper shortages or copper overload in diabetic conditions. Moreover, studies show that treated with copper chelators improve vascular function, maintain copper homeostasis, inhibit cuproptosis, and reduce cell toxicity, thereby alleviating diabetic neuropathy, retinopathy, nephropathy, and cardiomyopathy. However, the mechanisms reported in these studies are inconsistent or even contradictory. This review summarizes the precise and tight regulation of copper homeostasis processes, and discusses the latest progress in the association of diabetes and dietary copper/plasma copper. Further, the study pays close attention to the therapeutic potential of copper chelators and copper in diabetes and its complications, and hopes to provide new insight for the treatment of diabetes.

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Prospective association of metal levels with gestational diabetes mellitus and glucose: A retrospective cohort study from South China

Cited by 22 publications

References 31 publications

Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study

Fasting Plasma Glucose Mediates the Prospective Effect of Maternal Metal Level on Birth Outcomes: A Retrospective and Longitudinal Population-Based Cohort Study

Magnesium Status, Genetic Variants of Magnesium‐Related Ion Channel Transient Receptor Potential Membrane Melastatin 6 (TRPM6) and the Risk of Gestational Diabetes Mellitus in Chinese Pregnant Women: A Nested Case–Control Study

Copper and Diabetes: Current Research and Prospect

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