Prospective association between body mass index at midlife and healthy aging among French adults

Ruhunuhewa, Indunil; Adjibade, Moufidath; Andreeva, Valentina A.; Galán, Pilar; Herçberg, Serge; Assmann, Karen E.; Kesse‐Guyot, Emmanuelle

doi:10.1002/oby.21853

Cited by 11 publications

(15 citation statements)

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“…This adipose tissue inflammation appears to mediate insulin resistance [ 26 ], and has also been suggested to be involved in the etiology of cardiovascular disease [ 27 ], depression [ 28 ] and cognitive decline [ 29 , 30 ]. In line with this, various observational studies have revealed a detrimental role of an elevated body mass index (BMI) or an increased body fat percentage with respect to multidimensional concepts of HA [ 6 , 7 , 8 , 21 , 22 , 23 , 24 , 31 ], including a previous article based on data from the French ‘Supplementation with Vitamins and Mineral Antioxidants’ (SU.VI.MAX-‘SUpplémentation en VItamines et Minéraux AntioXydants’) study [ 31 ].…”

Section: Introductionmentioning

confidence: 87%

The Mediating Role of Overweight and Obesity in the Prospective Association between Overall Dietary Quality and Healthy Aging

et al. 2018

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Background: Our objective was to quantify to what extent the association between adherence to the French nutritional recommendations at midlife, measured by the Programme National Nutrition Santé-Guideline Score (PNNS-GS), and healthy aging (HA) is mediated by body mass index (BMI) status. Methods: We analyzed data from 2249 participants of the French ‘Supplementation with Vitamins and Mineral Antioxidants’ (SU.VI.MAX-‘SUpplémentation en VItamines et Minéraux AntioXydants’) cohort. At baseline (1994–1995), data on BMI status (<25 vs. ≥25 and <30 vs. ≥30) and diet were collected. At follow-up (2007–2009), HA status (yes/no) was evaluated via a multidimensional concept focusing on chronic disease incidence, physical and cognitive functioning, mental and social health, pain, and perceived health. Relative risks (RR) were estimated by extensively adjusted robust-error-variance Poisson regression, and counterfactual-based mediation analysis was performed. Results: Our HA criteria were met by 39% of participants. We identified a positive direct relation of a greater adherence to the French nutritional recommendations, with the probability of HA (RRQuartile 4 vs. quartile 1 = 1.31 (95% confidence interval (CI) = 1.13, 1.53)), and an indirect relation mediated by BMI status (1.01 (95% CI: 1.01, 1.02)), accounting for 5% of the total relation. Conclusion: These results indicate that high dietary quality may contribute to the preservation of overall health during aging, partly via obesity prevention and partly via other mechanisms.

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Section: Introductionmentioning

confidence: 87%

The Mediating Role of Overweight and Obesity in the Prospective Association between Overall Dietary Quality and Healthy Aging

et al. 2018

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“…Obesity is well known to be associated with shorter healthy life expectancy. 6,8 In light of our results, tackling obesity earlier during the life course is crucial to achieve healthy ageing.…”

Section: Discussionmentioning

confidence: 87%

“…4,5 Numerous observational studies have investigated whether body mass index (BMI) is associated with self-rated health among middle-aged adults, generally finding that obese persons are more likely to report poor self-rated health and to live more years with poor health than persons of normal weight. [6][7][8] The mechanisms underlying the overall trends between BMI and self-rated health are likely to vary substantially according to age, as conditions contributing to self-rated health change in importance across the lifespan. Developments in overall BMI may be important, because in sedentary populations BMI mainly reflects fat mass, 9 which may affect physical functioning and incidence of disease such as type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Body mass index trajectories preceding first report of poor self-rated health: a longitudinal case-control analysis of the English Longitudinal Study of Ageing:

Hulmán

Ibsen

Laursen

et al. 2018

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Body% mass% index% trajectories% preceding% first% report% of% poor% self5rated% health:% a% longitudinal%case5control%analysis%of%the%English%Longitudinal%Study%of%Ageing% % Adam%Hulman" Word%count%main%text/abstract%2717/246"% Number%of%tables/figures"1/3" References%24" % Keywords%SelfIrated"health,"body"mass"index,"longitudinal"caseIcontrol"study,"trajectory" 2" ! ABSTRACT% Background%Studies"have"consistently"found"that"obesity"is"associated"with"poor"selfIrated" health,"but"how"body"mass"index"(BMI)"developed"in"the"lead"up"to"poor"selfIrated"health"is" unknown.% Methods%We"nested"a"longitudinal"caseIcontrol"study"in"the"English"Longitudinal"Study"of"Ageing"(1998I2015)"to"investigate"BMI"trajectories"in"the"years"preceding"a"first"selfIreport" of"poor"health.

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“…Baseline characteristics of the study population were provided as the median and interquartile range (IQR) and as frequency (percentage). Based on literature [22,35] and a statistically significant interaction between carbohydrate, fat, and protein intake and BMI (P for interaction < 0.01), BMI was considered an effect modifier and all results are presented by the total population and by strata of BMI. Differences in baseline characteristics between strata of BMI were assessed by analysis of variance or Chi-square test.…”

Section: Discussionmentioning

confidence: 99%

Macronutrient intake and frailty: the Rotterdam Study

et al. 2019

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Purpose To investigate the longitudinal association between the macronutrient composition of the diet and frailty. Methods Data were obtained from 5205 Dutch middle-aged and older adults participating in the Rotterdam Study. Frailty was measured using a frailty index based on the accumulation of 38 health-related deficits, score between 0 and 100, and a higher score indicating more frailty. Frailty was assessed at baseline and 11 years later (range of 23 years). Macronutrient intake was assessed using food-frequency questionnaires. The association between macronutrients and frailty over time was evaluated using multivariable linear regression, adjusted for the frailty index at baseline, energy intake, and other relevant confounders. All analyses were performed in strata of BMI. Results Median frailty index score was 13.8 points (IQR 9.6; 19.1) at baseline and increased by a median of 2.3 points (IQR − 2.0; 7.6) after 11 years. Overall, we found no significant associations between intake of carbohydrates or fat and frailty over time. We did observe a significant positive association between an iso-energetic intake of 10 g protein and frailty over time (β 0.31 (95% CI 0.06; 0.55)) which was mainly driven by animal protein (β 0.31 (95% CI 0.07; 0.56)). It did not depend on whether it was substituted fat or carbohydrates. Conclusions Our findings suggest that a reduction in the intake of animal protein may improve the overall health status over time in a relatively healthy population. More research is needed on the optimal macronutrient composition of the diet and frailty in more vulnerable populations.

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Prospective association between body mass index at midlife and healthy aging among French adults

Abstract: This study provides novel evidence that an elevated BMI at midlife may jeopardize the preservation of health during aging. Our results also highlight the importance of maintaining a healthy metabolic profile during midlife.

Cited by 11 publications

References 41 publications

The Mediating Role of Overweight and Obesity in the Prospective Association between Overall Dietary Quality and Healthy Aging

The Mediating Role of Overweight and Obesity in the Prospective Association between Overall Dietary Quality and Healthy Aging

Body mass index trajectories preceding first report of poor self-rated health: a longitudinal case-control analysis of the English Longitudinal Study of Ageing:

Macronutrient intake and frailty: the Rotterdam Study

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