Prospection of recent chitosan biomedical trends: Evidence from patent analysis (2009–2020)

Kurakula, Mallesh; Naveen, N. Raghavendra

doi:10.1016/j.ijbiomac.2020.10.043

Cited by 62 publications

(46 citation statements)

References 133 publications

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“…They are cheap, biocompatible, and show low or no toxicity. For tailoring of the functional attributes, the natural polysaccharides can be modulated by physical, chemical, or enzymatic alterations [12,13]. Different polysaccharides used as biopolymers are Agarose, Gum Arabic, Tragacanth, Alginate, Gellan gum, Chitin/Chitosan, Starch, Carrageenan, Dextran, Bacterial Cellulose, Nanocellulose, Xanthan gum.…”

Section: Polysaccharidesmentioning

confidence: 99%

“…It is used in colon-specific drug delivery as it is stable over the upper GI environment. It is preferred for better application in combination with other biopolymers like xanthan gum and chitosan [12,[30][31][32][33].…”

Section: Agarosementioning

confidence: 99%

“…Inulin: Inulin is a natural substance obtained from vegetables and is recognized for its probiotic effect. It is applicable for colon targeted delivery due to its stable nature in the stomach and intestine on partial hydrolysis [12].…”

Section: Agarosementioning

confidence: 99%

“…Its electrostatic properties are favorable for the development of hybrid systems. The availability of chitosan in different molecular grades and degree of acetylation enable it for the fabrication of biocomposites [1,12,[34][35][36][37][38][39][40][41][42][43][44].…”

Section: Agarosementioning

confidence: 99%

“…It contains two polysaccharides namely amylose (linear) and amylopectin (branched). Starch is suitable for physical, chemical, or enzymatic modifications to achieve specific functional characteristics as modified starch that suit the biomedical and pharmaceutical applications [12]. Starch is widely used in targeted as well as controlled delivery of drugs and bioactive through its fabrication as nanoparticles, microparticles, inclusion complexes, composites, etc.…”

Section: Agarosementioning

confidence: 99%

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Advances in Functionalized Hybrid Biopolymer Augmented Lipid-based Systems: A Spotlight on Their Role in Design of Gastro Retentive Delivery Systems

2021

Archives of Gastroenterology Research

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Biopolymers are the polymers extracted from living organisms either from renewable plant or animal sources are gaining importance due to their better biodegradability, biocompatibility, less/no immunogenicity, less/no toxicity, and availability. Polysaccharides (e.g., chitosan, cellulose), polypeptides (e.g., collagen, silk), and polynucleotides are the important class of biopolymers that are finding multidisciplinary applications in biomedical fields. At the other end, lipid-based systems are having their special concern in drug delivery due to their advantages over other excipient systems. In this present review, various classes of biopolymers and their fusion with conventional lipids for amalgam entity using advanced techniques for futuristic biomedicine applications are outlined. The comprehensive focuses on upbringing the importance and types of functionalization techniques explored for designing deliverable for various unmet clinical needs. Along with recent trends, the scrutiny even addresses the future perspective of these hybrid systems impacting in addressing the pharceutical, formulational and clinical challenges in treating gasteroentric diseases.

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Section: Polysaccharidesmentioning

confidence: 99%

Section: Agarosementioning

confidence: 99%

Section: Agarosementioning

confidence: 99%

Section: Agarosementioning

confidence: 99%

Section: Agarosementioning

confidence: 99%

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Advances in Functionalized Hybrid Biopolymer Augmented Lipid-based Systems: A Spotlight on Their Role in Design of Gastro Retentive Delivery Systems

2021

Archives of Gastroenterology Research

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DMTMM‐mediated grafting reaction of glucuronic acid on chitosan

Ye²,

Gong³

et al. 2022

J of Applied Polymer Sci

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Compared with traditional conjugates 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS), 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) is an emerging biological coupling reagent and has been used in the amidation of hyaluronic acid. In this paper, DMTMM was used to achieve the amidation of chitosan (CS) with glucuronic acid (GA) in an aqueous medium to generate a GA-CS derivative. The grafting efficacy was preliminarily compared with the EDC/NHS-mediated reaction. As a result, the substitution degree of 17.6% for DMTMM-mediated grafting and 13.1% for EDC/NHS chemistry indicated that DMTMM-mediated synthesis of GA-CS appeared to be more efficient. The reaction kinetics experiments showed that GA-CS derivative with a degree of substitution up to about 26.1% was obtained using equal molar ratios of DMTMM and GA exceeding CS at room temperature. These results indicate that employing DMTMM as a coupling agent is a feasible and promising strategy for the amidation modification of chitosan.

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Chitosan and Chitooligosaccharides: Antifungal Potential and Structural Insights

de Azevedo,

Souza,

Monteiro Júnior

et al. 2024

Chemistry & Biodiversity

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Chitosan is a cationic polysaccharide derived from chitin deacetylation. This polysaccharide and its oligosaccharides have many biological activities and can be used in several fields due to their favorable characteristics, such as biodegradability, biocompatibility, and non‐toxicity. This review explores the antifungal potential of chitosan and chitooligosaccharides and the conditions needed for their activity and mechanisms of action to kill the fungal cells. Chitosan and chitooligosaccharides sources, chemical properties and applications are discussed in this review. It also addresses the threat fungi pose to human health and crop production and how these saccharides have proven effective against these microorganisms. The mechanisms underlying the antifungal activity, the cellular processes triggered by chitosan and chitooligosaccharides in fungal cells, and the future perspectives for their use as potential antifungal agents are also examined.

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Prospection of recent chitosan biomedical trends: Evidence from patent analysis (2009–2020)

Cited by 62 publications

References 133 publications

Advances in Functionalized Hybrid Biopolymer Augmented Lipid-based Systems: A Spotlight on Their Role in Design of Gastro Retentive Delivery Systems

Advances in Functionalized Hybrid Biopolymer Augmented Lipid-based Systems: A Spotlight on Their Role in Design of Gastro Retentive Delivery Systems

DMTMM‐mediated grafting reaction of glucuronic acid on chitosan

Chitosan and Chitooligosaccharides: Antifungal Potential and Structural Insights

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