Advances in Functionalized Hybrid Biopolymer Augmented Lipid-based Systems: A Spotlight on Their Role in Design of Gastro Retentive Delivery Systems

Abstract

Biopolymers are the polymers extracted from living organisms either from renewable plant or animal sources are gaining importance due to their better biodegradability, biocompatibility, less/no immunogenicity, less/no toxicity, and availability. Polysaccharides (e.g., chitosan, cellulose), polypeptides (e.g., collagen, silk), and polynucleotides are the important class of biopolymers that are finding multidisciplinary applications in biomedical fields. At the other end, lipid-based systems are having their special concern in drug delivery due to their advantages over other excipient systems. In this present review, various classes of biopolymers and their fusion with conventional lipids for amalgam entity using advanced techniques for futuristic biomedicine applications are outlined. The comprehensive focuses on upbringing the importance and types of functionalization techniques explored for designing deliverable for various unmet clinical needs. Along with recent trends, the scrutiny even addresses the future perspective of these hybrid systems impacting in addressing the pharceutical, formulational and clinical challenges in treating gasteroentric diseases.

A review on amorphous solid dispersions for improving physical stability and dissolution: Role of polymers

“…The largest deviation was observed with 40%w/w drug load among all drug loads. The chemical shift in 1 D 1 H, 13 C, and 15 N CP MAS NMR spectra between crystalline and amorphous acetaminophen indicates presence of hydrogen bonding between drug and polymer 43 .…”

“…Bioavailability can be improved by buccal drug delivery, microneedles, parenteral administration, controlled drug delivery, nanoparticulate drug delivery, complexation, Liquisolid technique 51 etc. [6][7][8][9][10][11][12][13][14][15][16] . Around 40% of the marketed drugs and 90% of the API in clinical development face solubility challenges.…”

Novel Applications of Hot Melt Extrusion Technology

“…Nanoparticles have several advantages improving solubility, improving bioavailability, targeting drug release capability, controlled drug release capability and others [38][39][40][41][42][43][44][45][46][47] . Fenofibrate solid lipid nanoparticles were prepared using HME technology using a quality-by-design approach.…”

Approaches to Improve Oral Bioavailability of Antihypertensive Drugs: A Mini-Review

“…Delivering drugs that have low aqueous solubility and/or permeability (BCS class II & IV) is a complicated task due to poor bioavailability caused by pH variation in the gastrointestinal tract (GIT) [34][35][36][37][38][39][40][41][42][43] . The pH difference can impact the pharmacological activity of a drug by any of the chemical degradation pathways like oxidation, deamidation, or hydrolysis of both small molecules and large molecules 44 .…”