Propylthiouracil: 4-6 Year Follow-Up of Selected Patients With Graves' Disease

Low Remission After Therapy for Graves Disease

“…16,24, 28), and disease of progressing severity in three cases(No. 30, 32, 37), which was thought to indicate a poor prognosis for remis¬ sion.Total urinary iodide content was measured in eight of the 44 patients reported (patients2,5,6,16,18,32, 35, 38). Eight consecutive 12-hourly urine samples were collected from these pa¬ tients prior to institution of therapy.Total iodine content was measured in each sample and was expressed as the mean of the four days of collection (micrograms per day).Remission was observed in only four of 35 (11.4%) patients (No.…”

Clinical pharmacology of antithyroid compounds

“…Large quantities of iodotyrosines are found in the urine of these children and may contribute to a persistent loss of iodide from the body. '09, 103 Tissue obtained by biopsy of the thyroid glands 13G as weIl as from other organs"" fails to deiodinate mono-and diiodotyrosine in vitro, The entire subject of inborn errors of thyroid hormonogenesis has recently been reviewed,'08, 1605…”