“…Major drawbacks for most of these processes are the use of stoichiometric to excess amounts of toxic cyanide source, generation of heavy metal waste, requirement of relatively high temperatures (often >100 °C), long reaction times, or the requirement of a reactive aryl halide source (aryl iodides and bromides are generally preferred) [14,24]. Recently, other approaches, such as the dehydration of primary amides [25,26,27,28] or aldoximes [29,30,31,32], and one pot synthesis from aldehydes [33,34,35,36,37,38,39,40,41,42,43] have gained particular attention in lieu of directly attaching the nitrile group. However, harsh reaction conditions, high temperatures, and functional groups intolerance are some of the problems still associated with these recent methods.…”